Results 111 to 120 of about 20,314 (255)

Comparison of PEGylated and non-PEGylated proticles: An in vitro and in vivo study

European Journal of Pharmaceutical Sciences, 2019
The development of so-called Proticles opens attractive possibilities for new drug delivery systems. Proticles are nanoparticles (NPs), which are formed by self-assembly of negatively charged oligonucleotides in combination with the positively charged peptide protamine.
Katja Fresacher, Anna Helbok, Martin Reiser, Sandra Blass, Christine Rangger, Christian Mair, Elisabeth von Guggenberg, Clemens Decristoforo, Fritz Andreae, Andreas Zimmer   +9 more
openaire   +2 more sources

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Advanced nanotherapeutics for combating ocular infections: Rational design, antimicrobial mechanisms, and therapeutic breakthroughs

BMEMat, EarlyView.
Nanomaterials revolutionize ocular infection treatment by enabling targeted drug delivery and enhanced antimicrobial efficacy against resistant pathogens. This review systematically explores their rational design, multimodal mechanisms, and translational potential for next‐generation anti‐infective therapies.
Yujia Liu, Xuetian Wen, Yue Tan, Rui Zeng, Yijuan Zhang, Tong Lin, Lan Gong, Zichao Luo   +7 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Site-specific PEGylation at histidine tags [PDF]

, 2012
The efficacy of protein-based medicines can be compromised by their rapid clearance from the blood circulatory system. Achieving optimal pharmacokinetics is a key requirement for the successful development of safe protein-based medicines.
Somavarapu, Satyanarayana, Farys, Monika, Edwards, Jeff, Badescu, George, Swierkosz, Julia, Laurine, Emmanuelle, Bird, Matthew, Choi, Ji-won, Bryant, Penny, Zloh, Mire, Cong, Yuehua, Brocchini, Steve, Hodgson, Ian, Heise, Charles, Khayrzad, Farzad, Heidelberger, Sibylle, Liddell, John, Singh, Ruchi, Pawlisz, Estera, Balan, Sibu, Sivasankar, Amrita, Dubey, Sitara, Peciak, Karolina, Tommasi, Rita, Muroni, Maurizio, Powell, Keith, Godwin, Antony   +26 more
core  

PEGylation affects the self-assembling behaviour of amphiphilic octapeptides [PDF]

, 2019
Surfactant-like peptides are a class of amphiphilic macromolecules, which are able to self-assemble in water forming different supramolecular structures.
Perinelli DR, Casettari L, Doutch, James, Doutch J, Palmieri, Giovanni Filippo, Campana M, Casettari, Luca, Singh I, Vllasaliu, Driton; id_orcid, Palmieri GF, Campana, Mario, Vllasaliu, Driton, Vllasaliu D, Perinelli, Diego Romano, Singh, Ishwar   +14 more
core   +1 more source

Quercetin‐zinc coordination polymer coated CaCO3 nanoparticles potentiate radiotherapy through reprogramming tumor immunosuppression

BMEMat, EarlyView.
Synthesis of QZCaCO3‐PEG to synergistically enhance the immunogenicity of radiotherapy through concurrent Zn2+‐induced cancer cell pyroptosis and Que‐mediated hypoxia amelioration through sequentially suppressing TGF‐β secretion and ECM deposition. Abstract Radiotherapy has demonstrated broad applications in treating solid tumors, but the hostile tumor
Chunjie Wang, Hengze Ding, Yu Hao, Honglin An, Ziliang Dong, Minming Chen, Yujie Zhu, Quguang Li, Bin Huang, Liangzhu Feng   +9 more
wiley   +1 more source

Self-Assembly PEGylation Retaining Activity (SPRA) Technology via a Host–Guest Interaction Surpassing Conventional PEGylation Methods of Proteins [PDF]

, 2017
Polyethylene glycol (PEG) modification (PEGylation) is one of the best approaches to improve the stabilities and blood half-lives of protein drugs; however, PEGylation dramatically reduces the bioactivities of protein drugs.
Tatsunori Hirotsu (3633700), Koki Wada (3633703), Keiichi Motoyama (822116), Hidetoshi Arima (822122), Irhan Ibrahim Abu Hashim (3633697), Taishi Higashi (822117), Shogo Misumi (2289145)   +6 more
core   +1 more source

Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics

Chemistry – A European Journal, EarlyView.
A modular polyethylene glycol (PEG) scaffold enables rapid assembly of dual peptide agonists using strain‐promoted azide–alkyne cycloaddition (SPAAC) and copper‐catalysed azide–alkyne cycloaddition (CuAAC). Glucagon‐like peptide‐1 (GLP‐1) and amylin agonists were combined with controlled valency, yielding low‐picomolar activity and receptor‐selective ...
Kristina A. Kostadinova, Jan L. Venne, Sona Krajcovicova, James Dodgson, Wouter F. J. Hogendorf, Thomas E. Nielsen, David Hymel, Hannah Bolt, Andie Collinson, Jason Day, Jefferson Revell, David R. Spring   +11 more
wiley   +1 more source

Effect of macrophage PEGylation on endocytosis modes [PDF]

, 2008
The objective of this work was to PEGylate macrophages and to study the impact of this modification on endocytosis modes. We showed that PEGylation of macrophages did not affect their ability to internalize tracers of phagocytosis and adsorptive ...
Ducreux, Julie, Annual Meeting & Exposition of the Controlled Release Society, Vanbever, Rita   +2 more
core