Results 101 to 110 of about 22,067 (275)

Solid Phase Pegylation of Hemoglobin

, 2009
A solid phase conjugation process was developed for attachment of polyethylene glycol to hemoglobin molecule. Bovine hemoglobin was loaded onto an ion exchange chromatography column and adsorbed by the solid medium.
Su, ZG, Zheng, Chunyang, Yu, Pengzhan, Ma, Guanghui, Su, Zhiguo, Suo, Xiaoyan, Lu, Xiuling   +6 more
core   +1 more source

Design, modeling, expression, and chemoselective PEGylation of a new nanosize cysteine analog of erythropoietin

, 2011
Reza Ahangari Cohan1, Armin Madadkar-Sobhani2,3, Hossein Khanahmad1, Farzin Roohvand4, Mohammad Reza Aghasadeghi4, Mohammad Hossein Hedayati5, Zahra Barghi5, Mehdi Shafiee Ardestani4, Davoud Nouri Inanlou1, Dariush Norouzian11Research and Development ...
Khanahmad H, Hedayati MH, Barghi Z, Ahangari Cohan R, Aghasadeghi MR, Nouri Inanlou D, F, Shafiee Ardestani M, Roohv, Norouzian D, Madadkar-Sobhani A   +10 more
core  

Tumor-Targeted Accumulation of Ligand-Installed Polymeric Micelles Influenced by Surface PEGylation Crowdedness

, 2017
With respect to the intriguing biocompatibility and the stealthy functions of poly(ethylene glycol),(PEGE), PEGylated nanopatticulates have- been intensively engineered for utilities as diug delivery vehicles.7o advocate the targeted druorinsportation ...
Wu, Sudong, Qiu, Yongming, Li, Zhen, Chen, Qixian, Yang, Jinjun, Chen, Xiyi, Liu, Deqiang, Yang, Xi, Liu, Jun   +8 more
core  

Site-Specific PEGylation at Histidine Tags

, 2016
The efficacy of protein-based medicines can be compromised by their rapid clearance from the blood circulatory system. Achieving optimal pharmacokinetics is a key requirement for the successful development of safe protein-based medicines.
Steve Brocchini (215656), Antony Godwin (1593661), Emmanuelle Laurine (1593685), Ji-won Choi (1593703), Sitara Dubey (2113366), Farzad Khayrzad (1831675), Penny Bryant (1593667), Karolina Peciak (1593673), Sibylle Heidelberger (2113363), Ruchi Singh (408288), Ian Hodgson (654977), Estera Pawlisz (1831672), Mire Zloh (215658), Jeff Edwards (1593682), Rita Tommasi (1593676), Charles Heise (2113357), Amrita Sivasankar (2113369), Yuehua Cong (831076), Monika Farys (1831669), John Liddell (2113360), George Badescu (1593712), Maurizio Muroni (1831678), Sibu Balan (2113354), Keith Powell (2113372), Julia Swierkosz (1593718), Satyanarayana Somavarapu (1783153), Matthew Bird (1233507)   +26 more
core   +1 more source

Effects of PEGylation on the physicochemical properties and in vivo distribution of organic nanotubes

, 2014
Wuxiao Ding, Hiroyuki Minamikawa, Naohiro Kameta, Toshimi Shimizu, Mitsutoshi Masuda Nanosystem Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan Abstract: Application of organic nanotubes ...
Ding W, Kameta N, Masuda M, Shimizu T, Minamikawa H   +4 more
core  

Follicle Stimulating Hormone in Cattle Breeding: Fundamentals, Innovations, and Scope

Animal Research and One Health, EarlyView.
FSH is crucial in cattle reproduction, with exogenous administration enhancing breeding and embryo production. Recombinant FSH offers advantages over pituitary‐extracted variants, including fewer injections, reduced stress, and safer production. These innovations improve breeding efficiency, optimize reproductive outcomes, and contribute to sustainable
Muhammad Shahzad, Hubdar Ali Kolachi, Jesse Oluwaseun Ayantoye, Xiaomeng Zhang, Muhammad Usman Mehmood, Rajilan Hilali Shanga, Pengcheng Wan, Xueming Zhao   +7 more
wiley   +1 more source

Polymerization and stability of actin conjugated with polyethylene glycol

Biophysics and Physicobiology
This study aimed to elucidate the impact of polyethylene glycol (PEG) conjugation on protein-protein interactions by investigating the properties of PEG-conjugated actin (PEG-actin).
Masaya Sagara, Kuniyuki Hatori
doaj   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Enzymatic PEGylation of oligonucleotides

, 2013
The gene and RNAi therapies as well as therapeutic aptamers attracted a great interest owing to the potential high selectivity and the theoretical possibility to treat a wide range of diseases, even those that have no other therapies. Unfortunately, this
Pasqualin M., PASUT, GIANFRANCO, SOSIC, ALICE, GATTO, BARBARA   +3 more
core