Results 81 to 90 of about 20,314 (255)

Effects of PEG surface density and chain length on the pharmacokinetics and biodistribution of methotrexate-loaded chitosan nanoparticles

International Journal of Nanomedicine, 2018
Zaina Ait Bachir,1,* YuKun Huang,1,* MuYe He,1 Lei Huang,1 XinYu Hou,1 RongJun Chen,2 Feng Gao1,3,4 1Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai, People’s Republic of China ...
Ait Bachir Z, Huang Y, He M, Huang L, Hou X, Chen R, Gao F   +6 more
doaj  

Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery

Scientific Reports, 2017
A new acidly sensitive PEGylated polyethylenimine linked by Schiff base (PEG-s-PEI) was designed to render pH-sensitive PEGylation nanoassemblies through multiple interactions with indomethacin and docetaxel (DTX).
Guanren Zhao, Ling Long, Lina Zhang, Mingli Peng, Ting Cui, Xiaoxun Wen, Xing Zhou, Lijun Sun, Ling Che   +8 more
doaj   +1 more source

Effect of PEGylation on assembly morphology and cellular uptake of poly ethyleneimine-cholesterol conjugates for delivery of sorafenib tosylate in hepatocellular carcinoma [PDF]

BioImpacts, 2018
Introduction: Sorafenib (SFB) is an FDA-approved chemotherapeutic agent with a high partition coefficient (log P = 4.34) for monotherapy of hepatocellular carcinoma (HCC).
Maryam Monajati, Shirin Tavakoli, Samira Sadat Abolmaali, Gholamhossein Yousefi, AliMohammad Tamaddon   +4 more
doaj   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Effects of PEGylation on the physicochemical properties and in vivo distribution of organic nanotubes [PDF]

, 2014
Wuxiao Ding, Hiroyuki Minamikawa, Naohiro Kameta, Toshimi Shimizu, Mitsutoshi Masuda Nanosystem Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan Abstract: Application of organic nanotubes ...
Ding W, Kameta N, Masuda M, Shimizu T, Minamikawa H   +4 more
core  

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Chemical and Enzymatic Site Specific PEGylation of hGH [PDF]

, 2016
Several strategies for site-specific PEGylation have been successfully exploited to conjugate poly­(ethylene glycol) (PEG) to pharmaceutical proteins.
Anna Mero (1675675), Gianfranco Pasut (657272), Débora da Silva Freitas (1978786)   +2 more
core   +1 more source

Balancing Stealth and Targetability: cCPP‐ and PEG‐Modified Liposomes for the Targeted Delivery of Anti‐HER2 Nanobodies

Advanced Science, EarlyView.
This study addresses the rapid renal clearance of anti‐HER2 nanobodies by developing specialized liposomal carriers. It details the formulation of dual modified liposomes, demonstrating how PEGylation preserves structural integrity and cell‐penetrating peptides enhance cellular interaction.
Giulia Pander, Maria del Pilar Palacios Cisneros, Clara Certa, Megan Stierli, Katharina Beck, Nicolas Färber, Lisa Blank, Fiona Tanner, Eric Mühlberg, Sabrina Wohlfart, Christian Kleist, Jörg Huwyler, Gert Fricker, Walter Mier, Philipp Uhl   +14 more
wiley   +1 more source

Enzymatic PEGylation of oligonucleotides [PDF]

, 2013
The gene and RNAi therapies as well as therapeutic aptamers attracted a great interest owing to the potential high selectivity and the theoretical possibility to treat a wide range of diseases, even those that have no other therapies. Unfortunately, this
Pasqualin M., PASUT, GIANFRANCO, SOSIC, ALICE, GATTO, BARBARA   +3 more
core