Results 61 to 70 of about 20,314 (255)
The impact of PEGylation patterns on the in vivo biodistribution of mixed shell micelles [PDF]
, 2013 Hongjun Gao,2# Jinjian Liu,1# Cuihong Yang,1 Tangjian Cheng,2 Liping Chu,1 Hongyan Xu,1 Aimin Meng,1 Saijun Fan,1 Linqi Shi,2 Jianfeng Liu11Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine ...
Cheng T +8 more
core
Mechanistic Insights into the Stabilization of srcSH3 by PEGylation [PDF]
, 2016 Protein PEGylation (attaching PEG chains to proteins) has been widely used in pharmaceuticals and nanotechnology. Although it is widely known that PEGylation can increase the thermodynamic stability of proteins, the underlying mechanism remains elusive ...
Wei Meng (505670) +5 more
core +1 more source
Engineering hemoglobin to enable homogenous PEGylation without modifying protein functionality [PDF]
, 2020 In order to infuse hemoglobin into the vasculature as an oxygen therapeutic or blood substitute, it is necessary to increase the size of the molecule to enhance vascular retention. This aim can be achieved by PEGylation.
Gretton S. +17 more
core +4 more sources
Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects
Advanced Materials, EarlyView.Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley +1 more source
Surface PEGylation on PLA membranes via micro-swelling and crosslinking for improved biocompatibility/hemocompatibility [PDF]
, 2015 Poly(lactic acid) (PLA) has attracted growing attention as a sustainable and environmentally benign membrane material. The good biocompatibility/hemocompatibility is essential for hemodialysis membranes.
Liu, Fu +5 more
core
Site-Specific PEGylation at Histidine Tags [PDF]
, 2016 The efficacy of protein-based medicines can be compromised by their rapid clearance from the blood circulatory system. Achieving optimal pharmacokinetics is a key requirement for the successful development of safe protein-based medicines.
Steve Brocchini (215656) +26 more
core +1 more source
Pegylation – in search of balance and enhanced bioavailability [PDF]
, 2022 In the process of finding better therapeutics, thousands of new molecules are synthesised every day. Many of these can be poorly soluble in water, leading to a potentially promising drug being rejected during testing due to its poor solubility ...
Dawid Łażewski +2 more
core +2 more sources
Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy
Pharmaceutics, 2020 Here, a novel protonable copolymer was realized for the production of polyplexes with a siRNA (inhibitor of STAT6 expression in asthma), with the aim of a pulmonary administration.
Emanuela Fabiola Craparo +4 more
doaj +1 more source
Advanced Materials, EarlyView.Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou +5 more
wiley +1 more source
Drug Design, Development and Therapy, 2016 Hadi Mirzaei,1 Bahram Kazemi,1 Mojgan Bandehpour,1 Alireza Shoari,2 Vahid Asgary,2 Mehdi Shafiee Ardestani,3 Armin Madadkar-Sobhani,4 Reza Ahangari Cohan2 1Department of Biotechnology, School of Medicine, Shahid Beheshti University of Medical Sciences ...
Mirzaei H +7 more
doaj