Results 51 to 60 of about 32,225 (250)

Exactly defined molecular weight poly(ethylene glycol) allows for facile identification of PEGylation sites on proteins

Nature Communications
PEGylation (the covalent attachment of one or more poly(ethylene glycol) (PEG) units to a therapeutic) is a well-established technique in the pharmaceutical industry to increase blood-residence time and decrease immunogenicity.
Maria J. Burggraef, Adam Oxley, Naveed A. Zaidi, Pedro R. Cutillas, Piers R. J. Gaffney, Andrew G. Livingston   +5 more
doaj   +1 more source

Disregarded effect of biological fluids in siRNA delivery : human ascites fluid severely restricts cellular uptake of nanoparticles [PDF]

, 2015
Small interfering RNA (siRNA) offers a great potential for the treatment of various diseases and disorders. Nevertheless, inefficient in vivo siRNA delivery hampers its translation into the clinic.
Braeckmans, Kevin, Ceelen, Wim, Dakwar, George, De Smedt, Stefaan, Demeester, Jo, Remaut, Katrien   +5 more
core   +2 more sources

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Modular Control of PEG‐Poly(2‐Oxazoline) Co‐Assembly Enables Tunable Aggregate Properties for Intraocular Pressure Management

Advanced Healthcare Materials, EarlyView.
A thermo‐responsive poly(2‐oxazoline)‐based injectable formulation is developed to modulate intraocular pressure (IOP) in both normal and hypotonic eyes. By adjusting the PEG content, the aggregation behavior is finely tuned, enabling IOP elevation without long‐term deposition.
Yuji Tanaka, Shohei Morikawa, Shigehito Osawa   +2 more
wiley   +1 more source

Targeting GD2-Positive Tumor Cells by Pegylated scFv Fragment–Drug Conjugates Carrying Maytansinoids DM1 and DM4

Current Issues in Molecular Biology, 2023
Oligomerization of antibody fragments via modification with polyethylene glycol (pegylation) may alter their function and properties, leading to a multivalent interaction of the resulting constructs with the target antigen.
Daniel V. Kalinovsky, Irina V. Kholodenko, Elena V. Svirshchevskaya, Alexey V. Kibardin, Dmitry Yu. Ryazantsev, Fedor N. Rozov, Sergey S. Larin, Sergey M. Deyev, Roman V. Kholodenko   +8 more
doaj   +1 more source

Hyperpolarized Long-T1 Silicon Nanoparticles for Magnetic Resonance Imaging [PDF]

, 2009
Silicon nanoparticles are experimentally investigated as a potential hyperpolarized, targetable MRI imaging agent. Nuclear T_1 times at room temperature for a variety of Si nanoparticles are found to be remarkably long (10^2 to 10^4 s) - roughly ...
Akerman M. E., Atanasijevic T., Brown C., Dementyev A. E., Ferrari M., Gao X., Golman K., Gupta A. K., Hirsch L. R., Howarter J. A., Högemann D., Jain R. K., Jana N. R., Jiang W., Ladd T. D., Leawoods J. C., Li D., Liu W., Nelson S. J., Nishi Y., Park J. H., Patz S., Schröder L., Schwartz M. P., Shen T. D., Shulman R. G., Simberg D., Tasciotti E., Weissleder R., Weissleder R., Xu H., Zhang Z., Zhao L.   +32 more
core   +2 more sources

PEGylated liposomes: immunological responses [PDF]

Science and Technology of Advanced Materials, 2019
A commonly held view is that nanocarriers conjugated to polyethylene glycol (PEG) are non-immunogenic. However, many studies have reported that unexpected immune responses have occurred against PEG-conjugated nanocarriers. One unanticipated response is the rapid clearance of PEGylated nanocarriers upon repeat administration, called the accelerated ...
Mohamed, Marwa, Lila, Amr S. Abu, Shimizu, Taro, Alaaeldin, Eman, Hussein, Amal, Sarhan, Hatem A., Szebeni, Janos, Ishida, Tatsuhiro   +7 more
openaire   +3 more sources

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

PEGylated Versus Non-PEGylated γ Fe2O3@Alendronate Nanoparticles [PDF]

Journal of Bioanalysis & Biomedicine, 2012
Thanks to their magnetic properties, superparamagnetic iron oxide nanoparticles are considered as a good delivery vehicle after grafting a therapeutical drug on their surface. For additional “stealth” characteristics, PEGylation of surfaces is necessary.
F, Benyettou, Hardouin, J, Lecouvey, Marc, Jouni, H, L, Motte   +4 more
openaire   +2 more sources

Mapping Nanoscale Protein‐Corona Kinetics of DoE‐Optimized Perfluorocarbon Encapsulated‐PLGA Nanoparticles by In Situ, Time‐Resolved Synchrotron SAXS

Advanced Healthcare Materials, EarlyView.
A two‐phase workflow (OFAT screening followed by central composite design) maps how processing variables tune PFCE‐PLGA nanoparticle size, dispersity, surface charge, loading, and 19F‐MRI signal. In situ, time‐resolved synchrotron SAXS tracks albumin‐corona growth on intact dispersions and reveals PFCE‐dependent adsorption pathways.
Joice Maria Joseph, Maria Rosa Gigliobianco, Cristina Minnelli, Paolo Moretti, Francesco Spinozzi, Giovanna Mobbili, Sara Pistolesi, Cristina Casadidio, Gabriella Teti, Roberta Censi, Stefano Antonio Gattone, Piera Di Martino   +11 more
wiley   +1 more source