Results 51 to 60 of about 20,314 (255)

Modular Control of PEG‐Poly(2‐Oxazoline) Co‐Assembly Enables Tunable Aggregate Properties for Intraocular Pressure Management

Advanced Healthcare Materials, EarlyView.
A thermo‐responsive poly(2‐oxazoline)‐based injectable formulation is developed to modulate intraocular pressure (IOP) in both normal and hypotonic eyes. By adjusting the PEG content, the aggregation behavior is finely tuned, enabling IOP elevation without long‐term deposition.
Yuji Tanaka, Shohei Morikawa, Shigehito Osawa   +2 more
wiley   +1 more source

Structural and functional studies of hemoproteins from polar marine organisms [PDF]

, 2011
Antarctica, more than any other habitat on Earth, represents a unique natural laboratory for fundamental research on the processes that have produced biological diversity in extreme environments and, at the same time, offers potential biotechnological ...
Coppola, Daniela
core  

Experimental study of the acute toxicity of the oral form of pegylated interferon α2-b

Сибирский научный медицинский журнал, 2019
The aim of the study is to investigate the acute toxicity of the oral finished dosage form of pegylated interferon α-2b, obtained with the help of electron-beam synthesis technology. Material and methods.
D. N. Kinsht, P. G. Madonov, T. S. Tartynova, A. A. Churin, E. Y. Sherstoboev   +4 more
doaj   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

Solid Phase Pegylation of Hemoglobin [PDF]

, 2009
A solid phase conjugation process was developed for attachment of polyethylene glycol to hemoglobin molecule. Bovine hemoglobin was loaded onto an ion exchange chromatography column and adsorbed by the solid medium.
Su, ZG, Zheng, Chunyang, Yu, Pengzhan, Ma, Guanghui, Su, Zhiguo, Suo, Xiaoyan, Lu, Xiuling   +6 more
core   +1 more source

Harnessing HSPB1-targeted radiotheranostics for early diagnosis and precision therapy in colorectal cancer

Nano Research
Colorectal cancer (CRC) has high global incidence and mortality, yet effective diagnostic tools for detecting the adenoma to adenocarcinoma transition are lacking, making identification of adenomas with malignant transformation potential essential for ...
Shu Liu, Yuhong Wang, Mengmeng Xu, Chonghai Zhang, Xulu Yang, Fei Peng, Huan Yang, Teng Liu, Weifeng Li, Judong Luo, Kai Yang, Lin Hu   +11 more
doaj   +1 more source

Design, Synthesis and Characterization of Nano niosomal Delivery system Containing paclitaxel drug for Drug Delivery to Osteosarcoma Cell Line (Saos-2)

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2022
Introduction: Osteosarcoma is the most common type of bone cancer which current chemotherapy treatment strategies have not been very successful due to multiple drug resistance and diverse side effects.
Mohammad Javad Pourmahmoudian, Seyed Mahdi Kalantar, Bibi Fatemeh Haghiralsadat   +2 more
doaj  

Preclinical study of the toxicity of the oral form of pegylated interferon α-2b under its long-term use

Сибирский научный медицинский журнал, 2019
The aim of the study is to investigate the chronic toxicity of the oral finished dosage form of pegylated interferon α-2b, obtained with the help of electron-beam synthesis technology. Materials and methods.
A. A. Churin, E. Y. Sherstoboev, D. N. Kinsht, T. S. Tartynova, P. G. Madonov   +4 more
doaj   +1 more source

Targeting GD2-Positive Tumor Cells by Pegylated scFv Fragment–Drug Conjugates Carrying Maytansinoids DM1 and DM4

Current Issues in Molecular Biology, 2023
Oligomerization of antibody fragments via modification with polyethylene glycol (pegylation) may alter their function and properties, leading to a multivalent interaction of the resulting constructs with the target antigen.
Daniel V. Kalinovsky, Irina V. Kholodenko, Elena V. Svirshchevskaya, Alexey V. Kibardin, Dmitry Yu. Ryazantsev, Fedor N. Rozov, Sergey S. Larin, Sergey M. Deyev, Roman V. Kholodenko   +8 more
doaj   +1 more source

Affinity‐Tuned Albumin Hitchhiking Extends the Bioorthogonal Capture Window in Pretargeting Radiotheranostics

Advanced Healthcare Materials, EarlyView.
Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He, Nicholas L. Fletcher, Gayathri R. Ediriweera, Yifei Zhu, James Humphries, Christopher B. Howard, Jiazheng Wang, Craig A. Bell, Kristian Kempe, Kristofer J. Thurecht   +9 more
wiley   +1 more source