Results 51 to 60 of about 22,067 (275)

Preclinical study of the toxicity of the oral form of pegylated interferon α-2b under its long-term use

Сибирский научный медицинский журнал, 2019
The aim of the study is to investigate the chronic toxicity of the oral finished dosage form of pegylated interferon α-2b, obtained with the help of electron-beam synthesis technology. Materials and methods.
A. A. Churin, E. Y. Sherstoboev, D. N. Kinsht, T. S. Tartynova, P. G. Madonov   +4 more
doaj   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the model drug curcumin [PDF]

Royal Society Open Science, 2018
Magnesium ferrite nanoparticles, with diameters around 25 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behaviour, with a maximum magnetization of 16.2 emu g−1, a coercive field of 22.1 Oe and a ...
Beatriz D. Cardoso, Irina S. R. Rio, Ana Rita O. Rodrigues, Francisca C. T. Fernandes, B. G. Almeida, A. Pires, A. M. Pereira, J. P. Araújo, Elisabete M. S. Castanheira, Paulo J. G. Coutinho   +9 more
doaj   +1 more source

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

Overcoming barriers to poor protein PEGylation efficiency. [PDF]

, 2022
Les protéines jouent le rôle le plus dynamique et le plus diversifié de toutes les macromolécules de l'organisme. Elles possèdent des structures chimiques complexes qui leur permettent de catalyser des réactions spécifiques, de servir d'échafaudages ...
Meziadi, Ahlem
core   +2 more sources

Blood–Brain Barrier Regulation: Evolving From Classic Strategies to Electrochemical Ion and Reactive Oxygen Species Control

Advanced Healthcare Materials, EarlyView.
Conventional therapies suffer from poor blood–brain barrier (BBB) penetration and disordered ion/reactive oxygen species (ROS) homeostasis, hindering precise neurological treatment. Electrochemical strategies achieve accurate spatiotemporal regulation of neural homeostasis.
Xiaokang Hu, Caiyu Liu, Meijun Pang, Zhiyuan Shi, Dong Ming, Xiuyun Liu   +5 more
wiley   +1 more source

An Expansion on Protein PEGylation for cancer therapeutics : from Bench to Bedside.

, 2020
PEGylation is a biochemical modification of biomolecules using polyethylene glycol (PEG) that confers several desirable properties to the modified biomolecule.
Bhavanasi, Sneharika Nagasai.
core  

Computational and nonglycosylated systems: a simpler approach for development of nanosized PEGylated proteins

Drug Design, Development and Therapy, 2016
Hadi Mirzaei,1 Bahram Kazemi,1 Mojgan Bandehpour,1 Alireza Shoari,2 Vahid Asgary,2 Mehdi Shafiee Ardestani,3 Armin Madadkar-Sobhani,4 Reza Ahangari Cohan2 1Department of Biotechnology, School of Medicine, Shahid Beheshti University of Medical Sciences ...
Mirzaei H, Kazemi B, Bandehpour M, Shoari A, Asgary V, Ardestani MS, Madadkar-Sobhani A, Ahangari Cohan R   +7 more
doaj  

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Solid-phase protein PEGylation: Achieving mono-PEGylation through molecular tethering [PDF]

, 2009
Protein PEGylation (covalent attachment of poly(ethylene glycol) or PEG to proteins) is an excellent example of a drug delivery system that improves pharmacokinetics and pharmacodynamic properties of therapeutics.
Damodaran, Vinod Babu
core   +1 more source