Results 41 to 50 of about 20,314 (255)

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, EarlyView.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source

Non-covalent PEGylation of therapeutic proteins [PDF]

, 2016
Cette thèse en sciences pharmaceutiques se penchait sur la stabilisation des protéines thérapeutiques en solutions. Cette classe de médicaments possède quelques avantages par rapport aux petites molécules.
Reichert, Christian
core   +1 more source

Exactly defined molecular weight poly(ethylene glycol) allows for facile identification of PEGylation sites on proteins

Nature Communications
PEGylation (the covalent attachment of one or more poly(ethylene glycol) (PEG) units to a therapeutic) is a well-established technique in the pharmaceutical industry to increase blood-residence time and decrease immunogenicity.
Maria J. Burggraef, Adam Oxley, Naveed A. Zaidi, Pedro R. Cutillas, Piers R. J. Gaffney, Andrew G. Livingston   +5 more
doaj   +1 more source

Dual pH- and GSH-Responsive Degradable PEGylated Graphene Quantum Dot-Based Nanoparticles for Enhanced HER2-Positive Breast Cancer Therapy

Nanomaterials, 2020
Dual stimuli-responsive degradable carbon-based nanoparticles (DS-CNPs) conjugated with Herceptin (HER) and polyethylene glycol (PEG) have been designed for the treatment of HER2-positive breast cancer.
Na Re Ko, Se Young Van, Sung Hwa Hong, Seog-Young Kim, Miran Kim, Jae Seo Lee, Sang Ju Lee, Yong-kyu Lee, Il Keun Kwon, Seung Jun Oh   +9 more
doaj   +1 more source

Supramolecular PEGylation of biopharmaceuticals [PDF]

Proceedings of the National Academy of Sciences, 2016
Significance Pharmaceutical practice has transitioned away from small-molecule drugs to the use of biomolecules (peptides, proteins, and antibodies). Where formulation of small molecules focused primarily on solubility, biopharmaceuticals introduced an array of complications due to their more complex secondary and tertiary structures,
Matthew J. Webber, Eric A. Appel, Brittany Vinciguerra, Abel B. Cortinas, Lavanya S. Thapa, Siddharth Jhunjhunwala, Lyle Isaacs, Robert Langer, Daniel G. Anderson   +8 more
openaire   +4 more sources

Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery

Advanced Functional Materials, EarlyView.
This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae Pryor, Paula T. Hammond   +4 more
wiley   +1 more source

Solid-phase protein PEGylation: Achieving mono-PEGylation through molecular tethering [PDF]

, 2009
Protein PEGylation (covalent attachment of poly(ethylene glycol) or PEG to proteins) is an excellent example of a drug delivery system that improves pharmacokinetics and pharmacodynamic properties of therapeutics.
Damodaran, Vinod Babu
core   +1 more source

Folate-targeting annonaceous acetogenins nanosuspensions: significantly enhanced antitumor efficacy in HeLa tumor-bearing mice

Drug Delivery, 2018
Annonaceous acetogenins (ACGs) are one of the most active constituents isolated from Annona species with potent antitumor activity. However, the poor solubility and severe side effect greatly limit their use in clinic.
Haowen Li, Yijing Li, Hui Ao, Dongdong Bi, Meihua Han, Yifei Guo, Xiangtao Wang   +6 more
doaj   +1 more source

Synthesis of PEGylated Human Serum Albumin by Maleimide-Thiol Chemistry and Histopathological Evaluation in a Mice Model of Carrageenan-Induced Inflammation [PDF]

Trends in Pharmaceutical Sciences, 2019
Occasional incompetence of human serum albumin (HSA) as a plasma expander is linked to severity of the underlying endothelial cell injury so that HSA can readily extravasate if structural integrity of the endothelial is compromised.
Mehdi Hoorang, Alimohammad Tamaddon, Gholamhosein Yousefi   +2 more
doaj   +1 more source

Zwitteration As an Alternative to PEGylation

Langmuir, 2011
A direct, head-to-head comparison of the efficacy of a zwitterionic versus a poly(ethylene glycol), PEG, coating in preventing protein adsorption to silica and aggregation of silica nanoparticles is presented. The same siloxane coupling chemistry was employed to yield surfaces with similar coverages of both types of ligand.
Zaki G, Estephan, Philip S, Schlenoff, Joseph B, Schlenoff   +2 more
openaire   +2 more sources