Results 31 to 40 of about 20,314 (255)
Drug Delivery, 2018 Poly-l-lysine (PLL) nanoparticle (NP) system was prepared for the controlled release of curcumin (CUR) by pH stimuli, and its theranostic efficacy on cancer was compared to that of CUR solution in vitro and in vivo.
Dae Hyeok Yang +4 more
doaj +1 more source
Pharmacokinetic Consequences of Pegylation [PDF]
Drug Delivery, 2006 Pegylation, generally described as the molecular attachment of polyethylene glycols (PEGs) with different molecular weights to active drug molecules or surface treatment of drug-bearing particles with PEGs, is one of the most promising and extensively studied strategies with the goal of improving the pharmacokinetic behavior of the therapeutic drugs. A
Mehrdad, Hamidi +2 more
openaire +2 more sources
Improved antithrombotic activity and diminished bleeding side effect of a PEGylated alpha IIb beta 3 antagonist, disintegrin [PDF]
, 2017 Introduction: The applicability of protein drugs is confined by protein degradation and rapid elimination. PEGylation of polypeptides improves protein stability by sterically obstructing the degradation by serumproteases and reduces renal clearance by ...
彭惠琴;黃德富 +1 more
core +1 more source
Data in Brief, 2019 The average number of methoxy poly(ethylene glycol) (mPEG) chains grafted to a protein – also known as the degree of PEGylation – is a fundamental parameter for characterizing a bioconjugate.
Ahlem Zaghmi +5 more
doaj +1 more source
Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the model drug curcumin [PDF]
Royal Society Open Science, 2018 Magnesium ferrite nanoparticles, with diameters around 25 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behaviour, with a maximum magnetization of 16.2 emu g−1, a coercive field of 22.1 Oe and a ...
Beatriz D. Cardoso +9 more
doaj +1 more source
PEGylation-dependent metabolic rewiring of macrophages with silk fibroin nanoparticles [PDF]
, 2019 Silk fibroin nanoparticles are emerging as promising nanomedicines, but their full therapeutic potential is yet to be realized. These nanoparticles can be readily PEGylated to improve colloidal stability and to tune degradation and drug release profiles;
Wongpinyochit, Thidarat +14 more
core +1 more source
Theoretical study on pegylation reaction mechanisms of IFN-α-2a, IFN-α-2b and IFN-β-1a [PDF]
Journal of the Serbian Chemical Society, 2017 Ab initio and DFT calculations have been carried out to study the reaction mechanism between interferons (IFNs) α-2a, α-2b and β-1a and polyethylene glycol (PEG) group.
Taqavian Mohammad +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Size Exclusion PEGylation Reaction Chromatography Modelling [PDF]
, 2006 Size exclusion PEGylation reaction chromatography was investigated using a model developed by Fee (2005). Column dispersion was neglected and the PEGylation reaction was modelled as second order.
Kapadi, Ajith Nayak
core
Mono-PEGylation of ribonuclease A: High PEGylation efficiency by thiolation with small molecular weight reagent [PDF]
, 2012 PEGylation can improve the therapeutic potential of ribonuclease A (RNase A), a cancer chemotherapeutic agent. However, the common PEGylation that targets at the e-amino groups of proteins can lead to imprecise control of the stoichiometry of the protein-
Hu, Tao +6 more
core +1 more source