Results 31 to 40 of about 22,067 (275)
PEGylation of native disulfide bonds in proteins
, 2006 PEGylation has turned proteins into important new biopharmaceuticals. The fundamental problems with the existing approaches to PEGylation are inefficient conjugation and the formation of heterogeneous mixtures. This is because poly(ethylene glycol) (PEG)
Balan, Sibu +5 more
core +4 more sources
Supramolecular PEGylation of biopharmaceuticals [PDF]
Proceedings of the National Academy of Sciences, 2016 Significance Pharmaceutical practice has transitioned away from small-molecule drugs to the use of biomolecules (peptides, proteins, and antibodies). Where formulation of small molecules focused primarily on solubility, biopharmaceuticals introduced an array of complications due to their more complex secondary and tertiary structures,
Matthew J. Webber +8 more
openaire +4 more sources
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Size Exclusion PEGylation Reaction Chromatography Modelling [PDF]
, 2006 Size exclusion PEGylation reaction chromatography was investigated using a model developed by Fee (2005). Column dispersion was neglected and the PEGylation reaction was modelled as second order.
Kapadi, Ajith Nayak
core
Effect of PEGylation on assembly morphology and cellular uptake of poly ethyleneimine-cholesterol conjugates for delivery of sorafenib tosylate in hepatocellular carcinoma [PDF]
BioImpacts, 2018 Introduction: Sorafenib (SFB) is an FDA-approved chemotherapeutic agent with a high partition coefficient (log P = 4.34) for monotherapy of hepatocellular carcinoma (HCC).
Maryam Monajati +4 more
doaj +1 more source
Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery
Advanced Functional Materials, EarlyView.A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon +5 more
wiley +1 more source
Zwitteration As an Alternative to PEGylation
Langmuir, 2011 A direct, head-to-head comparison of the efficacy of a zwitterionic versus a poly(ethylene glycol), PEG, coating in preventing protein adsorption to silica and aggregation of silica nanoparticles is presented. The same siloxane coupling chemistry was employed to yield surfaces with similar coverages of both types of ligand.
Zaki G, Estephan +2 more
openaire +2 more sources
, 2009 A solid-phase adsorption method was developed to circumvent the disadvantage of the conventional liquid-phase PEGylation, i.e. the heterogeneity of the PEGylated products.
Hu, Tao +5 more
core +1 more source
Nature CommunicationsPEGylation (the covalent attachment of one or more poly(ethylene glycol) (PEG) units to a therapeutic) is a well-established technique in the pharmaceutical industry to increase blood-residence time and decrease immunogenicity.
Maria J. Burggraef +5 more
doaj +1 more source
Polycaprolactone Nanoparticles as Promising Candidates for Nanocarriers in Novel Nanomedicines
Pharmaceutics, 2021 An investigation of the interactions between bio-polymeric nanoparticles (NPs) and the RAW 264.7 mouse murine macrophage cell line has been presented.
Sylwia Łukasiewicz +4 more
doaj +1 more source