Results 31 to 40 of about 32,225 (250)

Dual pH- and GSH-Responsive Degradable PEGylated Graphene Quantum Dot-Based Nanoparticles for Enhanced HER2-Positive Breast Cancer Therapy

Nanomaterials, 2020
Dual stimuli-responsive degradable carbon-based nanoparticles (DS-CNPs) conjugated with Herceptin (HER) and polyethylene glycol (PEG) have been designed for the treatment of HER2-positive breast cancer.
Na Re Ko, Se Young Van, Sung Hwa Hong, Seog-Young Kim, Miran Kim, Jae Seo Lee, Sang Ju Lee, Yong-kyu Lee, Il Keun Kwon, Seung Jun Oh   +9 more
doaj   +1 more source

Determination of the degree of PEGylation of protein bioconjugates using data from proton nuclear magnetic resonance spectroscopy

Data in Brief, 2019
The average number of methoxy poly(ethylene glycol) (mPEG) chains grafted to a protein – also known as the degree of PEGylation – is a fundamental parameter for characterizing a bioconjugate.
Ahlem Zaghmi, Andrea A. Greschner, Eduardo Mendez-Villuendas, Jun Yang Liu, Hendrick W. de Haan, Marc A. Gauthier   +5 more
doaj   +1 more source

Synthesis of PEGylated Human Serum Albumin by Maleimide-Thiol Chemistry and Histopathological Evaluation in a Mice Model of Carrageenan-Induced Inflammation [PDF]

Trends in Pharmaceutical Sciences, 2019
Occasional incompetence of human serum albumin (HSA) as a plasma expander is linked to severity of the underlying endothelial cell injury so that HSA can readily extravasate if structural integrity of the endothelial is compromised.
Mehdi Hoorang, Alimohammad Tamaddon, Gholamhosein Yousefi   +2 more
doaj   +1 more source

Nanoparticles in the treatment of chronic lung diseases [PDF]

, 2019
Nanoparticles, although considered a topic of modern medicine, actually have an interesting history. Currently, advances in nanomedicine hold great promise as drug carrier systems for sustained release and targeted delivery of diverse therapeutic agents.
Alexescu, Teodora G, Cosnarovici, Maria, Negrean, Vasile, Orasan, Olga H, Para, Ioana, Perne, Mirela G, Popovici, Ionela, Ruta, Victoria M, Tarmure, Simina, Todea, Doina A   +9 more
core   +2 more sources

Preparation of poly-l-lysine-based nanoparticles with pH-sensitive release of curcumin for targeted imaging and therapy of liver cancer in vitro and in vivo

Drug Delivery, 2018
Poly-l-lysine (PLL) nanoparticle (NP) system was prepared for the controlled release of curcumin (CUR) by pH stimuli, and its theranostic efficacy on cancer was compared to that of CUR solution in vitro and in vivo.
Dae Hyeok Yang, Hyun Joo Kim, Kyeongsoon Park, Jae Kwang Kim, Heung Jae Chun   +4 more
doaj   +1 more source

Er:Y₂O₃ and Nd:Y₂O₃ Nanoparticles: Synthesis, Pegylation, Characterization and Study of Their Luminescence Properties

Chemosensors, 2022
Lanthanide-doped yttrium oxide nanoparticles can display selective upconversion properties, rendering them invaluable in the field of nanomedicine for both sensing and diagnostics.
Regina Maria Chiechio, Rosalia Battaglia, Angela Caponnetto, Ester Butera, Giorgia Franzò, Riccardo Reitano, Michele Purrello, Marco Ragusa, Davide Barbagallo, Cristina Barbagallo, Cinzia Di Pietro, Valérie Marchi, Maria José Lo Faro, Annalinda Contino, Giuseppe Maccarrone, Paolo Musumeci   +15 more
doaj   +1 more source

Long acting growth hormone (LAGH), an update

Frontiers in Pediatrics, 2023
In 1957, Maurice Raben at Yale was able to isolate and purify growth hormone from cadaveric pituitary glands. Pituitary growth hormone was the only way to treat children with growth hormone (GH) deficiency, until 1985 when recombinant GH became available
Margaret Steiner Grillo, Jacklyn Frank, Paul Saenger   +2 more
doaj   +1 more source

Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo [PDF]

, 2019
Detoxification of gluten immunogenic epitopes is a promising strategy for the treatment of celiac disease. Our previous studies have shown that these epitopes can be degraded in vitro by subtilisin enzymes derived from Rothia mucilaginosa, a natural ...
Darwish, Ghassan, Helmerhorst, Eva J., Oppenheim, Frank G., Schuppan, Detlef, Wei, Guoxian   +4 more
core   +1 more source

PEGylated Systems in Pharmaceutics [PDF]

Polymer Science, Series C, 2020
This review addresses the use of poly(ethylene glycol) (PEG) and PEG conjugation for the design of novel dosage forms and the modification of biomolecules. The peculiarities of PEGylated nanoparticles, liposomes, proteins, enzymes, and small drug and polyelectrolyte molecules and their influence on systemic drug delivery, including overcoming of ...
Porfiryeva, N. N., Moustafine, R. I., Khutoryanskiy, V. V.   +2 more
openaire   +1 more source

Design of New Polyaspartamide Copolymers for siRNA Delivery in Antiasthmatic Therapy

Pharmaceutics, 2020
Here, a novel protonable copolymer was realized for the production of polyplexes with a siRNA (inhibitor of STAT6 expression in asthma), with the aim of a pulmonary administration.
Emanuela Fabiola Craparo, Salvatore Emanuele Drago, Nicolò Mauro, Gaetano Giammona, Gennara Cavallaro   +4 more
doaj   +1 more source