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PEGylation technology: addressing concerns, moving forward [PDF]
Drug DeliveryPEGylation technology, that is grafting of poly(ethylene glycol)(PEG) to biologics, vaccines and nanopharmaceuticals, has become a cornerstone of modern medicines with over thirty products used in the clinic.
Dmitri Simberg +5 more
doaj +8 more sources
PEGylated therapeutics in the clinic
Bioengineering & Translational Medicine, 2023 The covalent attachment of polyethylene glycol (PEG) to therapeutic agents, termed PEGylation, is a well‐established and clinically proven drug delivery approach to improve the pharmacokinetics and pharmacodynamics of drugs.
Yongsheng Gao +3 more
doaj +3 more sources
Shrinkage of pegylated and non-pegylated liposomes in serum [PDF]
Colloids and Surfaces B: Biointerfaces, 2014 An essential requisite for the design of nanodelivery systems is the ability to characterize the size, homogeneity and zeta potential of nanoparticles. Such properties can be tailored in order to create the most efficient drug delivery platforms. An important question is whether these characteristics change upon systemic injection.
Wolfram J +8 more
+9 more sources
To PEGylate or Not To PEGylate Therapeutics? [PDF]
Cell Chemical Biology, 2019 PEGylation is a common modulator of pharmacokinetics for therapeutic agents in vivo. In this issue of Cell Chemical Biology, Moreno et al. (2019) show anti-PEG antibodies may directly inhibit the activity of a PEGylated aptamer, RB006, both in vitro and in vivo, and the issues surrounding anti-PEG antibodies are discussed.
Keith E, Maier +2 more
openaire +2 more sources
PEGylation-Enabled Extended Cyclability of a Non-aqueous Redox Flow Battery [PDF]
, 2020 Non-aqueous redox flow batteries (RFBs) are promising energy storage devices owing to the broad electrochemical window of organic solvents. Nonetheless, the wide application of these batteries has been limited by the low stability and limited solubility ...
Junhang Dong (2350354) +6 more
core +1 more source
Microwave-Induced Transient Heating Accelerates Protein PEGylation [PDF]
, 2023 PEGylation is one of the most widely employed strategies to increase the circulatory half-life of proteins and to reduce immune responses. However, conventional PEGylation protocols often require excess reagents and extended reaction times because of ...
Ahlem Meziadi (14026197) +5 more
core +1 more source
Noncovalent PEGylation of l-Asparaginase Using PEGylated Polyelectrolyte [PDF]
Journal of Pharmaceutical Sciences, 2015 Noncovalent PEGylation has great potential for stabilization of therapeutic proteins. Here, we demonstrated that the noncovalent PEGylation with a PEGylated polyelectrolyte stabilized a therapeutic protein, l-asparaginase (ASNase). Anionic ASNase and cationic poly(ethylene glycol)-block-poly(N,N-dimethylaminoethyl methacrylate) (PEG-b-PAMA) formed a ...
Takaaki, Kurinomaru, Kentaro, Shiraki
openaire +2 more sources
PLoS ONE, 2012 Polyethylene glycol (PEG) was genetically incorporated into a polypeptide. Stop-anticodon-containing tRNAs were acylated with PEG-containing amino acids and were then translated into polypeptides corresponding to DNA sequences containing the stop codons.
Tada, S. +5 more
openaire +4 more sources
A solid-phase adsorption method for PEGylation of human serum albumin and staphylokinase: preparation, purification and biochemical characterization [PDF]
, 2009 A solid-phase adsorption method was developed to circumvent the disadvantage of the conventional liquid-phase PEGylation, i.e. the heterogeneity of the PEGylated products.
Hu, Tao +5 more
core +1 more source
An Expansion on Protein PEGylation for cancer therapeutics : from Bench to Bedside. [PDF]
, 2020 PEGylation is a biochemical modification of biomolecules using polyethylene glycol (PEG) that confers several desirable properties to the modified biomolecule.
Bhavanasi, Sneharika Nagasai.
core +2 more sources