Results 11 to 20 of about 22,067 (275)

PEGylation technology: addressing concerns, moving forward [PDF]

Drug Delivery
PEGylation technology, that is grafting of poly(ethylene glycol)(PEG) to biologics, vaccines and nanopharmaceuticals, has become a cornerstone of modern medicines with over thirty products used in the clinic.
Dmitri Simberg, Yechezkel Barenholz, Steve R. Roffler, Katharina Landfester, Alexander V. Kabanov, Seyed M. Moghimi   +5 more
doaj   +9 more sources

PEGylated therapeutics in the clinic

Bioengineering & Translational Medicine, 2023
The covalent attachment of polyethylene glycol (PEG) to therapeutic agents, termed PEGylation, is a well‐established and clinically proven drug delivery approach to improve the pharmacokinetics and pharmacodynamics of drugs.
Yongsheng Gao, Maithili Joshi, Zongmin Zhao, Samir Mitragotri   +3 more
doaj   +3 more sources

Shrinkage of pegylated and non-pegylated liposomes in serum [PDF]

Colloids and Surfaces B: Biointerfaces, 2014
An essential requisite for the design of nanodelivery systems is the ability to characterize the size, homogeneity and zeta potential of nanoparticles. Such properties can be tailored in order to create the most efficient drug delivery platforms. An important question is whether these characteristics change upon systemic injection.
Wolfram J, Suri K, Yang Y, Shen J, CELIA, Christian, Fresta M, Zhao Y, Shen H, Ferrari M.   +8 more
  +9 more sources

To PEGylate or Not To PEGylate Therapeutics? [PDF]

Cell Chemical Biology, 2019
PEGylation is a common modulator of pharmacokinetics for therapeutic agents in vivo. In this issue of Cell Chemical Biology, Moreno et al. (2019) show anti-PEG antibodies may directly inhibit the activity of a PEGylated aptamer, RB006, both in vitro and in vivo, and the issues surrounding anti-PEG antibodies are discussed.
Keith E, Maier, Christopher P, Rusconi, Matthew, Levy   +2 more
openaire   +2 more sources

Genetic PEGylation

PLoS ONE, 2012
Polyethylene glycol (PEG) was genetically incorporated into a polypeptide. Stop-anticodon-containing tRNAs were acylated with PEG-containing amino acids and were then translated into polypeptides corresponding to DNA sequences containing the stop codons.
Tada, S., Andou, T., Suzuki, T., Dohmae, N., EIRY KOBATAKE, Ito, Y.   +5 more
openaire   +4 more sources

Noncovalent PEGylation of l-Asparaginase Using PEGylated Polyelectrolyte [PDF]

Journal of Pharmaceutical Sciences, 2015
Noncovalent PEGylation has great potential for stabilization of therapeutic proteins. Here, we demonstrated that the noncovalent PEGylation with a PEGylated polyelectrolyte stabilized a therapeutic protein, l-asparaginase (ASNase). Anionic ASNase and cationic poly(ethylene glycol)-block-poly(N,N-dimethylaminoethyl methacrylate) (PEG-b-PAMA) formed a ...
Takaaki, Kurinomaru, Kentaro, Shiraki
openaire   +3 more sources

PK/PD modelling of comb-shaped PEGylated salmon calcitonin conjugates of differing molecular weights [PDF]

, 2010
Salmon calcitonin (sCT) was conjugated via cysteine-1 to novel comb-shaped end-functionalised (poly(PEG) methyl ether methacrylate) (sCT-P) polymers, to yield conjugates of total molecular weights (MW) inclusive of sCT: 6.5, 9.5, 23 and 40 kDa.
Jesús M. Frías, David J. Brayden, Brayden, David J., Claire T. Sayers, Haddleton, David M., Ryan, Sinéad M., Sayers, Claire T., Wang, Xuexuan, Sinéad M. Ryan, David M. Haddleton, Xuexuan Wang, Frías, Jesús M., Brayden, David James, Frias, Jesus Maria, Haddleton, David H., Ryan, Sinead   +15 more
core   +1 more source

Pharmacokinetic Consequences of Pegylation [PDF]

Drug Delivery, 2006
Pegylation, generally described as the molecular attachment of polyethylene glycols (PEGs) with different molecular weights to active drug molecules or surface treatment of drug-bearing particles with PEGs, is one of the most promising and extensively studied strategies with the goal of improving the pharmacokinetic behavior of the therapeutic drugs. A
Mehrdad, Hamidi, Amir, Azadi, Pedram, Rafiei   +2 more
openaire   +2 more sources

PEGylated Systems in Pharmaceutics [PDF]

Polymer Science, Series C, 2020
This review addresses the use of poly(ethylene glycol) (PEG) and PEG conjugation for the design of novel dosage forms and the modification of biomolecules. The peculiarities of PEGylated nanoparticles, liposomes, proteins, enzymes, and small drug and polyelectrolyte molecules and their influence on systemic drug delivery, including overcoming of ...
Porfiryeva, N. N., Moustafine, R. I., Khutoryanskiy, V. V.   +2 more
openaire   +1 more source

PEGylation-Enabled Extended Cyclability of a Non-aqueous Redox Flow Battery

, 2020
Non-aqueous redox flow batteries (RFBs) are promising energy storage devices owing to the broad electrochemical window of organic solvents. Nonetheless, the wide application of these batteries has been limited by the low stability and limited solubility ...
Junhang Dong (2350354), Jingchao Chai (3811834), Caroline K. Williams (8594949), Jianbing “Jimmy” Jiang (8594952), Xiao Wang (19312), Amir Lashgari (8594946), Zishu Cao (3341486)   +6 more
core   +1 more source