PEGylated Systems in Pharmaceutics [PDF]
Polymer Science, Series C, 2020 This review addresses the use of poly(ethylene glycol) (PEG) and PEG conjugation for the design of novel dosage forms and the modification of biomolecules. The peculiarities of PEGylated nanoparticles, liposomes, proteins, enzymes, and small drug and polyelectrolyte molecules and their influence on systemic drug delivery, including overcoming of ...
Porfiryeva, N. N. +2 more
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PK/PD modelling of comb-shaped PEGylated salmon calcitonin conjugates of differing molecular weights [PDF]
, 2011 Salmon calcitonin (sCT) was conjugated via cysteine-1 to novel comb-shaped end-functionalised (poly(PEG) methyl ether methacrylate) (sCT-P) polymers, to yield conjugates of total molecular weights (MW) inclusive of sCT: 6.5, 9.5, 23 and 40 kDa.
Jesús M. Frías +12 more
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The Effect of Length and Structure of Attached Polyethylene Glycol Chain on Hydrodynamic Radius, and Separation of PEGylated Human Serum Albumin by Chromatography [PDF]
Advanced Pharmaceutical Bulletin, 2021 Purpose: This study focuses on the effect of length and structure of attached polyethylene glycol (PEG) chain on hydrodynamic radius (Rh ) and chromatographic retention of PEGylated protein. To this aim human serum albumin (HSA) as a standard protein was
Parvin Akbarzadehlaleh +3 more
doaj +1 more source
Drug Delivery, 2018 This work aimed to achieve long-lasting delivery of radix ophiopogonis polysaccharide (ROP) by sucrose acetate isobutyrate (SAIB)-based in situ forming systems (ISFSs) alone or combined with mono-PEGylation of ROP.
LiNa Wang +5 more
doaj +1 more source
Polycaprolactone Nanoparticles as Promising Candidates for Nanocarriers in Novel Nanomedicines
Pharmaceutics, 2021 An investigation of the interactions between bio-polymeric nanoparticles (NPs) and the RAW 264.7 mouse murine macrophage cell line has been presented.
Sylwia Łukasiewicz +4 more
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PEGylation Reagents Selection Guide [PDF]
, 2019 PEGylation is a chemical process that forms a covalent bond between a PEG polymer and a substrate molecule including molecules, macromolecules, particles, and surfaces.
Scarlett (8326170)
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Structure-based antigenic epitope and PEGylation improve the efficacy of staphylokinase
Microbial Cell Factories, 2017 Staphylokinase (Sak) holds promise for use in thrombolytic therapy for acute myocardial infarction. However, its immunogenicity is a major disadvantage under clinical conditions.
Yanying Xu +9 more
doaj +1 more source
A novel solid-phase site-specific PEGylation enhances the in vitro and in vivo biostabilty of recombinant human keratinocyte growth factor 1. [PDF]
PLoS ONE, 2012 Keratinocyte growth factor 1 (KGF-1) has proven useful in the treatment of pathologies associated with dermal adnexae, liver, lung, and the gastrointestinal tract diseases. However, poor stability and short plasma half-life of the protein have restricted
Zhifeng Huang +9 more
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C-Terminal PEGylation Improves SAAP-148 Peptide’s Immunomodulatory Activities
Journal of Innate Immunity, 2023 Synthetic antibacterial and anti-biofilm peptide (SAAP)-148 was developed to combat bacterial infections not effectively treatable with current antibiotics. SAAP-148 is highly effective against antimicrobial-resistant bacteria without inducing resistance;
Miriam E. van Gent +7 more
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PEGylated gold nanoparticles-ribonuclease induced oxidative stress and apoptosis in colorectal cancer cells [PDF]
BioImpacts, 2020 Introduction: Currently, drug-induced reactive oxygen species (ROS) mediating apoptosis pathway have extensively been investigated in designing effective strategies for colorectal cancer (CRC) chemotherapy.
Mostafa Akbarzadeh Khiavi +7 more
doaj +1 more source