Results 21 to 30 of about 22,067 (275)
Drug Delivery, 2018 This work aimed to achieve long-lasting delivery of radix ophiopogonis polysaccharide (ROP) by sucrose acetate isobutyrate (SAIB)-based in situ forming systems (ISFSs) alone or combined with mono-PEGylation of ROP.
LiNa Wang +5 more
doaj +1 more source
Investigation of the Effect of PEG Detoxification on Diphtheria Vaccine [PDF]
Archives of Razi Institute, 2022 Immunization has been considered a successful global health program that saves many persons’ lives each year. The vaccines reduce the risk of getting the disease by building immunity in the body. Therefore, the constant availability of essential vaccines
T Hesari +6 more
doaj +1 more source
Structure-based antigenic epitope and PEGylation improve the efficacy of staphylokinase
Microbial Cell Factories, 2017 Staphylokinase (Sak) holds promise for use in thrombolytic therapy for acute myocardial infarction. However, its immunogenicity is a major disadvantage under clinical conditions.
Yanying Xu +9 more
doaj +1 more source
A novel solid-phase site-specific PEGylation enhances the in vitro and in vivo biostabilty of recombinant human keratinocyte growth factor 1. [PDF]
PLoS ONE, 2012 Keratinocyte growth factor 1 (KGF-1) has proven useful in the treatment of pathologies associated with dermal adnexae, liver, lung, and the gastrointestinal tract diseases. However, poor stability and short plasma half-life of the protein have restricted
Zhifeng Huang +9 more
doaj +1 more source
Microwave-Induced Transient Heating Accelerates Protein PEGylation
, 2023 PEGylation is one of the most widely employed strategies to increase the circulatory half-life of proteins and to reduce immune responses. However, conventional PEGylation protocols often require excess reagents and extended reaction times because of ...
Ahlem Meziadi (14026197) +5 more
core +1 more source
Drug Delivery, 2018 Poly-l-lysine (PLL) nanoparticle (NP) system was prepared for the controlled release of curcumin (CUR) by pH stimuli, and its theranostic efficacy on cancer was compared to that of CUR solution in vitro and in vivo.
Dae Hyeok Yang +4 more
doaj +1 more source
Data in Brief, 2019 The average number of methoxy poly(ethylene glycol) (mPEG) chains grafted to a protein – also known as the degree of PEGylation – is a fundamental parameter for characterizing a bioconjugate.
Ahlem Zaghmi +5 more
doaj +1 more source
Structural and functional studies of hemoproteins from polar marine organisms [PDF]
, 2011 Antarctica, more than any other habitat on Earth, represents a unique natural laboratory for fundamental research on the processes that have produced biological diversity in extreme environments and, at the same time, offers potential biotechnological ...
Coppola, Daniela
core +1 more source
Current Issues in Molecular Biology, 2023 Oligomerization of antibody fragments via modification with polyethylene glycol (pegylation) may alter their function and properties, leading to a multivalent interaction of the resulting constructs with the target antigen.
Daniel V. Kalinovsky +8 more
doaj +1 more source
PEGylation-dependent metabolic rewiring of macrophages with silk fibroin nanoparticles [PDF]
, 2019 Silk fibroin nanoparticles are emerging as promising nanomedicines, but their full therapeutic potential is yet to be realized. These nanoparticles can be readily PEGylated to improve colloidal stability and to tune degradation and drug release profiles;
Wongpinyochit, Thidarat +14 more
core +1 more source