Results 151 to 160 of about 31,898 (250)

Pegvaliase Treatment for Adolescents With Phenylketonuria: A Multi‐Site Study

JIMD Reports, Volume 67, Issue 2, March 2026.
ABSTRACT Phenylketonuria (PKU) is an inherited metabolic disorder causing elevated phenylalanine (Phe) levels and neurocognitive impairment if left untreated. While dietary therapy remains the treatment standard, adherence declines during adolescence. Pegvaliase, an injectable enzyme therapy approved for adults > 18 years in the United States, lowers ...
Suzanne Hollander, Briana Valli, Erika Vucko, Melissa Lah, Amarilis Sanchez‐Valle, Brittany M. Murray, Amy Kritzer, Stephanie Sacharow   +7 more
wiley   +1 more source

Cationic Poly(2‐oxazoline)s

Macromolecular Chemistry and Physics, Volume 227, Issue 5, 13 March 2026.
Cationic poly(2‐oxazoline)s (POx) have emerged as versatile materials for different biomedical applications. The combination of the pseudo‐peptidic polymer backbone and the amine‐derived cationic motifs results in well‐tolerated polymers with potential benefits for drug and gene delivery as well as antimicrobial development.
Meike N. Leiske
wiley   +1 more source

A Novel Peptide, HS1002, Enhances Antitumor Activity via Dual Targeting of the GnRH Receptor and Human Telomerase Reverse Transcriptase in Prostate Cancer Cells

MedComm, Volume 7, Issue 3, March 2026.
HS1002, a new peptide targeting GnRHR and hTERT, demonstrates significant Anticancer activity in prostate cancer cells. The mechanism of HS1002 can be attributed to the reduction of serum testosterone levels by desensitization of GnRHR, the downregulation of hTERT expression and telomerase activity, and the enhancement of Anticancer immunity.
Jae Hyeon Park, Joo Chan Lee, Swati Sharma, Chunxue Jiang, Haeun Lee, Hyun‐Ju Park, Hyung Sik Kim   +6 more
wiley   +1 more source

Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions

MedComm, Volume 7, Issue 3, March 2026.
Immune exhaustion is a well‐established hallmark of both cancer and chronic infection. This review proposes a novel “infection–exhaustion–tumor axis” framework, wherein chronic pathogens (e.g., oncogenic viruses) evade immune surveillance by hijacking inflammatory signaling to drive immune cell exhaustion, thereby creating immunosuppressive niches ...
Yali Song, Yazhi Mo, Si Chen, Yuemei Chen, Chunying Zhang, Shanying Deng, Juan Liao, Yi He, Wei Wang, Weidong Zheng, Tingting Zeng   +10 more
wiley   +1 more source

Targeting Tumor Dormancy and Recurrence: Molecular Mechanisms and Peptide Therapeutic Delivery

MedComm – Oncology, Volume 5, Issue 1, March 2026.
This review summarizes the molecular mechanisms that regulate tumor dormancy and its role in cancer recurrence, with emphasis on immune evasion, extracellular matrix remodeling, metabolic regulation and angiogenic switching. It further discusses emerging peptide–based therapeutic strategies aimed at detecting, modulating, and eliminating dormant tumor ...
Abdur Raheem Aleem, Atif Ali, Wajid Ali, Yuying Cheng, Zhibin Yan, Chaoyi Xia, Chenguang Liu, Caiyun Fu, Yiren Hu, Xi Wang   +9 more
wiley   +1 more source

Aerosol-synthesized siliceous nanoparticles: Impact of morphology and functionalization on biodistribution [PDF]

, 2018
Bandara, Nilantha, Biswas, Pratim, Diebolder, Philipp, Mpoy, Cedric, Raliya, Ramesh, Rogers, Buck E, Thimsen, Elijah, Vazquez-Pufleau, Miguel   +7 more
core   +2 more sources

Influence of radiotherapy dose rate on gold nanoparticle‐induced radiosensitization from high dose‐rate brachytherapy and external beam therapy

Medical Physics, Volume 53, Issue 3, March 2026.
Abstract Background Associated normal tissue toxicity from current radiotherapy (RT) treatments limits effective dose escalation in the tumor to achieve nominal treatment results. Gold nanoparticles (GNPs) as radiosensitizing agents to locally increase photoelectron production have gained interest as a safe and viable method to improve therapeutic ...
Daniel Cecchi, Nolan Jackson, Sacha Freeman, Kieren O'Neil, Mehran Goharian, Wayne Beckham, Devika B. Chithrani   +6 more
wiley   +1 more source

Synthesis Strategies, Therapeutic Roles, and Clinical Progress of Gold Nanoparticles in Biomedical Engineering

Nano Select, Volume 7, Issue 3, March 2026.
Gold nanoparticles are revolutionizing medicine with their unique properties including optical, electrical, physical, and chemical features, as well as surface plasmon resonance. This versatility has positioned GNPs as a cornerstone in nanotechnology, especially within biomedical applications. Their facile synthesis and surface functionalization enable
Nastaran Mohseni, Danial Farahmand, Sara Ali Hosseinzadeh, Kokab Khosravipour, Vahideh Valizadeh   +4 more
wiley   +1 more source

Nanomedicine Targeting Macrophage Immunometabolism in Atherosclerosis: Mechanisms and Therapeutic Prospects

Organ Medicine, Volume 3, Issue 1, Page 27-53, March 2026.
ABSTRACT Atherosclerosis, a chronic inflammatory–metabolic disorder, remains a leading cause of cardiovascular morbidity worldwide. This review explores the emerging paradigm of nanomedicine‐based targeting of macrophage immunometabolic reprogramming as a potentially transformative strategy for atherosclerosis treatment.
Zhenyu Liu, Wenfan Yang, Na Wang, Ya Wu
wiley   +1 more source

Melanin Nanoparticles as a Safe and Effective Iron Chelation Therapy: An ex vivo Assessment of Placental Transfer in Pregnant Beta-Thalassemia

International Journal of Nanomedicine
Nahla Bakhamis,1 Toluwalase Awoyemi,1 Manu Vatish,1 Helen Townley1,2 1Nuffield Department of Women’s & Reproductive Health, University of Oxford, Oxford, UK; 2Department of Engineering Science, University of Oxford, Oxford, UKCorrespondence ...
Bakhamis N, Awoyemi T, Vatish M, Townley H   +3 more
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