Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Test fixture for pellet-like electrical elements [PDF]
, 1969 Fixture for simultaneously supporting several components for electrical ...
Nasuti, A. J.
core +1 more source
Optimising the release rate of naproxen liqui-pellet: a new technology for emerging novel oral dosage form [PDF]
, 2019 Liqui-pellet is a new dosage form stemming from pelletisation technology and concept from liquisolid technology. In spite of liqui- pellet overcoming a major hurdle in liquisolid technology through achieving excellent flow property with high liquid load ...
Ghafourian, Taravat +2 more
core +2 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
New satellite systems for obtaining data for Geographic information systems [PDF]
Acta Montanistica Slovaca, 2006 Galileo will be the European global navigation satellite system, providing a highly accurate and a guaranteed global positioning service under the civilian control.
Miroslav Šimčák
doaj
The pH and ionic composition of the sub-embryonic fluid of the Japanese quail (Coturnix c. japonica) [PDF]
, 2005 The current theory of acid-base chemistry regards [H+] as a dependent variable: changes in pH of a fluid can only occur by alteration of strong ion concentrations ([Na+], [K+], [Cl-]).
Baggott, Glenn K., Pellet-Many, C
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Prediction of pellet mass thresholds for ELM triggering in low-collisionality, ITER-like discharges
Nuclear FusionIn ITER, pellets are calculated to require more than 8 times the mass than currently planned to reliably trigger edge-localized modes (ELMs). Unmitigated heat flux impulses from ELMs are intolerable in ITER at full power and current.
A. Wingen +4 more
doaj +1 more source
KARAKTERISTIK MUTU FISIK ORGANOLEPTIK PASCA PENYIMPANAN PELLET LIMBAH PENETASAN YANG DIBUAT DENGAN PENAMBAHAN BENTONIT [PDF]
, 2017 Penelitian untuk mengkaji pengaruh interaksi antara penambahan bentonit dan lama penyimpanan terhadap perubahan karakteristik mutu fisik organoleptik pellet limbah penetasan.
RAKHMAWATI, Yuli Eko +2 more
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source