Results 81 to 90 of about 438,568 (317)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Processing of Secondary Raw Materials from Ferrochrome Production via Agglomeration and Study of Their Mechanical Properties

Metals
In the process of producing ferroalloys, a large amount of secondary raw materials is formed, including slag, aspiration dusts and sludge. The recycling of secondary raw materials can create resources and bring environmental and economic benefits.
Yerlan Zhumagaliyev, Yerbol Shabanov, Maral Almagambetov, Maulen Jundibayev, Nursultan Ulmaganbetov, Salamat Laikhan, Akgul Jundibayeva, Aigerim Abilberikova, Nurbala Ubaidulayeva, Rysgul Adaibayeva   +9 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The Characteristics of Chitosan Derived from Lobster Shells and its Effect on Fungi Activity and Water Stability of Lobster Pellets

Jurnal Ilmiah Perikanan dan Kelautan
Graphical Abstract   Highlights of Research • The chitosan was successfully produced from lobster shells Panulirus homarus. • The characteristics and quality of chitosan from lobster shells Panulirus homarus were observed.
Muhsinul Ihsan, Ali Harris, Mukminah, Megawati, Nining Purwati, Handa Muliasari, Bayu Priyambodo, Clive Jones, Leo Nankervis   +8 more
doaj   +1 more source

Pellet Cladding Interaction In-Reactor Ramp Testing in a World Without the Halden Boiling Water Reactor

, 2022
Nicolas Woolstenhulme, Brian Durtschi, Charles P Folsom, Scott Holcombe, Colby Jensen, David Kamerman, Travis J Labossiere-Hickman, Nate Oldham, Daniel M. Wachs   +8 more
openalex   +2 more sources

Acceleration of Cryogenic Pellets for Shattered Pellet Injection

Fusion Engineering and Design, 2023
Á. Kovács, S. Zoletnik, D. Réfy, G. Papp, S. Hegedűs, T. Szepesi, E. Walcz, S. Jachmich, M. Lehnen, U. Kruezi, M. Dibon, P. de Marné, P. Heinrich, T. Peherstorfer   +13 more
openaire   +2 more sources

A PELLET FEEDER FOR THE BIRDS [PDF]

Journal of the Experimental Analysis of Behavior, 1979
An alternative means of delivering food to pigeons in operant conditioning research is described. The feeder allows greater control of the amount of food delivered and reduces the amount of time necessary for the pigeon to collect the food. It is possible to extend the length of experimental sessions due to the reduction of food intake.
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Gunshot Pellet Migration to the Right Ventricle: a Case Report and Literature Review [PDF]

, 2016
Jiachang Wu, Haien Zhao, Luo Yuanguo, Lei Wang, Lin Zhoudan, Hua Yang   +5 more
openalex   +1 more source