Results 71 to 80 of about 2,665 (161)

Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin

, 2011
Pendrin is an anion exchanger expressed in the apical regions of B and non-A, non-B intercalated cells. Since angiotensin II increases pendrin-mediated Cl− absorption in vitro, we asked whether angiotensin II increases pendrin expression in vivo and ...
Young Hee Kim, I. David Weiner, Vladimir Pech, Seongun Hong, James L. Bailey, Tadashi Inagami, Thomas M. Coffman, Diana Agazatian, Sharon W. Matthews, Susan M. Wall, Jill W. Verlander, Florence M. Whitehill, Thu Le, Donna B. Farley   +13 more
core   +1 more source

Reduction of Cellular Expression Levels Is a Common Feature of Functionally Affected Pendrin (SLC26A4) Protein Variants

Molecular Medicine, 2016
Sequence alterations in the pendrin gene (SLC26A4) leading to functionally affected protein variants are frequently involved in the pathogenesis of syndromic and nonsyndromic deafness.
Vanessa C S de Moraes, Emanuele Bernardinelli, Nathalia Zocal, Jhonathan A Fernandez, Charity Nofziger, Arthur M Castilho, Edi L Sartorato, Markus Paulmichl, Silvia Dossena   +8 more
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, Volume 600, Issue 2, Page 215-225, January 2026.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Pendrin protein expression is not detectable in mouse aorta.

, 2014
Pendrin immunoreactivity was explored by immunoblot of lysates from kidney and aorta of wild type (WT) and pendrin null (KO) mice. Each lane was loaded with 20 µg protein.
Laura Hansen (620249), Seongun Hong (620252), Truyen D. Pham (620251), Young Hee Kim (620242), Erik R. Walp (421801), Douglas C. Eaton (620247), Jing Ma (24574), Robert Bonsall (620245), Alexander M. El-Ali (620244), Rudolph L. Jr. Gleason (620250), Lori A. Walker (620243), Semra Ramosevac (620246), Jill W. Verlander (620248), Roy L. Sutliff (485240), Vladimir Pech (620253), Susan M. Wall (620254)   +15 more
core   +1 more source

Abstract Supplement

Pulmonary Medicine, Volume 2026, Issue 1, 2026.
 
Marzia Folegani, Semonti Nandi
wiley   +1 more source

Acute regulated expression of pendrin in human urinary exosomes

, 2018
It is well known that pendrin, an apical Cl−/HCO3−exchanger in type B intercalated cells, is modulated by chronic acid-base disturbances and electrolyte intake.
Pathare, Ganesh Tukaram, Cheval, Lydie, Dhayat, Nasser, Mohebbi, Nilufar, Fuster, Daniel Guido, Wagner, Carsten A., Neuhaus, Thomas J.   +6 more
core   +1 more source

Interspecific comparisons of anuran embryonic epidermal landscapes and energetic trade‐offs in response to changes in salinity

Developmental Dynamics, Volume 254, Issue 12, Page 1275-1296, December 2025.
Abstract Background Freshwater salinization is an emerging stressor in amphibian populations, and embryonic stages are most vulnerable. To better understand the variation in embryonic osmoregulation, we challenged embryos of two phylogenetically diverse anuran species, Xenopus laevis and Lithobates (Rana) sylvaticus, along a gradient of non‐lethal ...
Kourtnie Whitfield, Erica J. Crespi
wiley   +1 more source

Repurposing approved drugs as Pendrin (SLC26A4) inhibitors in allergic asthma: single-cell nomination, structure-based screening and functional validation

Frontiers in Pharmacology
Type-2 airway inflammation remodels the airway epithelium and drives mucus-associated transcriptional programs, making the epithelium an attractive source of drug targets in allergic asthma.
Jianxing Lai, Duoduo Zhao, Xuwen Wang, Binben Wang, Jinliang Nan   +4 more
doaj   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Pendrin expression evaluated by Western blotting.

, 2013
Proteins in crude membranes prepared from pooled inner ear tissues consisting of soft tissues from the cochlea and the vestibular labyrinth devoid of endolymphatic sac and crude membranes prepared from kidneys of Tg(−)Slc26a4Δ/+, Tg(−)Slc26a4Δ/Δ and Tg(+)
Nicolas Picard (259979), Andrew J. Griffith (203364), Dominique Eladari (426531), Donald G. Harbidge (432940), Daniel C. Marcus (261077), Fei Zhou (86034), Philine Wangemann (13200), Taku Ito (203353), Joel D. Sanneman (261074), Tracy Miesner (432943), Raoul Nelson (432941), Régine Chambrey (432942), Xiangming Li (302018)   +12 more
core   +1 more source