Results 51 to 60 of about 2,665 (161)

The effect of smoking on placental pendrin expression [PDF]

, 2017
WOS: 000395199200003PubMed: 28013561Pendrin is important for transport of iodine across the placenta. Thiocyanate coming from cigarette is a competitive inhibitor of iodine transport. We aimed to evaluate the pendrin immunostaining intensity in placentas
Özlü, Tülay, Karataş, Ahmet, Havva Erdem, Ahmet Karatas, Zehra Karatas, Bulent Cakmak, Çakmak, Bülent, Erdem, Havva, Karataş, Zehra, Tulay Ozlu   +9 more
core   +1 more source

From transporter to motor: Evolutionary and structural insights into the emergence of prestin's area‐motor activity in mammals

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Prestin, a member of the SLC26A family, is essential for the electromotility of mammalian outer hair cells, converting voltage changes into mechanical work. In contrast, nonmammalian orthologues function as anion transporters. To investigate the molecular and structural basis of this functional divergence, we performed ancestral sequence ...
Nicolás Fuentes‐Ugarte, Tiaren Ruiz‐Rojas, Felipe Garcia‐Olave, Alvaro Ruiz‐Fernandez, Jose Antonio Garate, Victor Castro‐Fernandez, Raul Araya‐Secchi   +6 more
wiley   +1 more source

Regulation of pendrin by pH: dependence on glycosylation

, 2011
Mutations in the anion exchanger pendrin are responsible for Pendred syndrome, an autosomal recessive disease characterized by deafness and goitre. Pendrin is highly expressed in kidney collecting ducts, where it acts as a chloride/bicarbonate exchanger ...
David Mordasini, Anie Azroyan, Gilles Crambert, Kamel Laghmani, Aurélie Edwards, Alain Doucet   +5 more
core   +1 more source

Pendrin: the thyrocyte apical membrane iodide transporter?

, 2011
In the thyroid, the transport of iodide from the extracellular space to the follicular lumen requires two steps: the transport in the cell at the basal side and in the lumen at the apical side. The first step is mediated by the Na(+)/I(-) symporter (NIS).
Claude Massart, Raspé, Eric, Véronique Kruys, Beauwens, Renaud, Renaud Beauwens, Jacques E. Dumont, Dumont, Jacques Emile, Eric Raspe, Jacqueline Van Sande, Golstein, Philippe, Massart, Claude, Van Sande, Jacqueline, Twyffels, Laure, Kruys, Véronique, Laure Twyffels, Philippe E. Golstein   +15 more
core   +1 more source

Alterations in placental pendrin expression in pre-eclampsia [PDF]

, 2014
oktay, murat/0000-0002-0893-4444;WOS: 000333583100007PubMed: 23941406Introduction: Pendrin is an integral membrane protein and plays a key role in extracellular fluid volume and blood pressure control.
Özlü, Tülay, Karataş, Ahmet, Albayrak, Mustafa, Oktay, Murat, Dönmez, Melahat Emine, Çakmak, Bülent, Keskin, Fatih, Erdem, Havva   +7 more
core   +1 more source

SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice.

PLoS Genetics, 2013
Mutations of SLC26A4 are a common cause of human hearing loss associated with enlargement of the vestibular aqueduct. SLC26A4 encodes pendrin, an anion exchanger expressed in a variety of epithelial cells in the cochlea, the vestibular labyrinth and the ...
Xiangming Li, Joel D Sanneman, Donald G Harbidge, Fei Zhou, Fei Zhou, Taku Ito, Raoul Nelson, Nicolas Picard, Régine Chambrey, Dominique Eladari, Tracy Miesner, Andrew J Griffith, Daniel C Marcus, Philine Wangemann   +13 more
doaj   +1 more source

Epithelial cell stretching and luminal acidification lead to a retarded development of stria vascularis and deafness in mice lacking pendrin. [PDF]

PLoS ONE, 2011
Loss-of-function mutations of SLC26A4/pendrin are among the most prevalent causes of deafness. Deafness and vestibular dysfunction in the corresponding mouse model, Slc26a4(-/-), are associated with an enlargement and acidification of the membranous ...
Hyoung-Mi Kim, Philine Wangemann
doaj   +1 more source

Case report: A case of SLC26A4 mutations causing pendred syndrome and non-cystic fibrosis bronchiectasis

Frontiers in Pediatrics, 2023
The SLC26A4 gene encodes the transmembrane protein pendrin, which is involved in the ion transport of chloride (Cl-), iodide (I-) or bicarbonate (HCO3-).
Kang Zhu, Yingkang Jin
doaj   +1 more source

The kidney and the balance of sulfur and nitrogen as fundamental components of pH homeostasis

Physiological Reports, Volume 14, Issue 10, May 2026.
Biochemical processes involved in ammoniagenesis and regulation of pH homeostasis. Abstract The homeostasis of blood and tissue pH is fundamental for life, and pH imbalances may lead to coma and death. The regulation of the acid–base balance involves primarily the lungs and kidneys, and is strictly integrated via the endocrine and nervous systems ...
Vincenzo Graziano, Antonio Angeloni, Paolo Mené, Andrea Bellelli   +3 more
wiley   +1 more source

Genomic analysis of a heterogeneous Mendelian phenotype: multiple novel alleles for inherited hearing loss in the Palestinian population

Human Genomics, 2006
Recessively inherited phenotypes are frequent in the Palestinian population, as the result of a historical tradition of marriages within extended kindreds, particularly in isolated villages. In order to characterise the genetics of inherited hearing loss
Walsh Tom, Rayan Amal, Sa'ed Judeh, Shahin Hashem, Shepshelovich Jeanne, Lee Ming K, Hirschberg Koret, Tekin Mustafa, Salhab Wa'el, Avraham Karen B, King Mary-Claire, Kanaan Moien   +11 more
doaj   +1 more source