Results 41 to 50 of about 2,665 (161)

A FRET-Based Approach for Quantitative Evaluation of Forskolin-Induced Pendrin Trafficking at the Plasma Membrane in Bronchial NCI H292 Cells

Cellular Physiology and Biochemistry, 2013
Background: Human pendrin (SLC26A4, PDS) is an integral membrane protein acting as an electroneutral anion exchanger. Loss of function mutations in pendrin protein cause Pendred syndrome, a disorder characterized by sensorineural deafness and a partial ...
Grazia Tamma, Marianna Ranieri, Silvia Dossena, Annarita Di Mise, Charity Nofziger, Maria Svelto, Markus Paulmichl, Giovanna Valenti   +7 more
doaj   +1 more source

Hypokalemia and Pendrin Induction by Aldosterone

, 2017
Aldosterone plays an important role in regulating Na-Cl reabsorption and blood pressure. Epithelial Na + channel, Na + -Cl − cotransporter, and Cl −
Toshiro Fujita, Daigoro Hirohama, Kenichi Ishizawa, Shigeru Shibata, Ning Xu, Tatsuo Shimosawa, Shunya Uchida, Wen Xiu Chang   +7 more
core   +1 more source

Pendrin abundance, subcellular distribution, and function are unaffected by either αENaC gene ablation or by increasing ENaC channel activity [PDF]

, 2023
The intercalated cell Cl$^{-}$/HCO$_{3}$$^{-}$ exchanger, pendrin, modulates ENaC subunit abundance and function. Whether ENaC modulates pendrin abundance and function is however unknown.
Kim, Young Hee, Abood, Delaney C, Loffing, Johannes, Chen, Chao, Verlander, Jill W, Pham, Truyen D, Wall, Susan M, Pech, Vladimir, Loffing-Cueni, Dominique   +8 more
core   +1 more source

Inhibition of Pendrin by a small molecule reduces Lipopolysaccharide-induced acute Lung Injury [PDF]

, 2020
Rationale: Pendrin is encoded by SLC26A4 and its mutation leads to congenital hearing loss. Additionally, pendrin is up-regulated in inflammatory airway diseases such as chronic obstructive pulmonary disease, allergic rhinitis, and asthma. In this study,
Shin, Mi Hwa, Hyun, Young-Min, Choi, Jae Young, Ryu, Ji-Hwan, Gi, Mia, Namkung, Wan, Jeon, Yoon, Han, Gyoonhee, Song, Doona, Park, Moo Suk, Park, Jinhong, Lee, Eun Hye, Seong, Je Kyung   +12 more
core   +2 more sources

The HEAT Repeat Protein MROH1 Deficiency Leads to Reduced Circulating Thyroid Hormone Levels in Mice

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
Global Mroh1 deficiency in male mice is associated with reduced circulating thyroid hormone level, late‐onset thyroid follicular remodelling, and lower whole‐thyroid abundance of Nkx2‐1, Foxe1, and Tg transcripts. These findings support a role for MROH1 in maintaining thyroid homeostasis and structural integrity.
Nami Ohuchi, Yoshinori Osaki, Yoshimi Nakagawa, Takafumi Miyamoto, Masaya Araki, Yuhei Mizunoe, Takaaki Matsuda, Yuki Murayama, Yoko Sugano, Hitoshi Iwasaki, Takashi Matsuzaka, Motohiro Sekiya, Hitoshi Shimano   +12 more
wiley   +1 more source

Expression of Human Pendrin in Diseased Thyroids

, 2003
We examined pendrin expression in various diseased thyroid tissues by immunohistochemistry (IHC) using antiserum raised against human pendrin and by real-time quantitative RT-PCR.
Akira Kawaoi, Nobuki Nakamura, Koichi Suzuki, Tetsuo Kondo, Akira Muramatsu, Ryohei Katoh, Shin-ichi Murata   +6 more
core   +1 more source

Mouse Models for Pendrin-Associated Loss of Cochlear and Vestibular Function

Cellular Physiology and Biochemistry, 2013
The human gene SLC26A4 and the mouse ortholog Slc26a4 code for the protein pendrin, which is an anion exchanger expressed in apical membranes of selected epithelia.
Philine Wangemann
doaj   +1 more source

Developmental changes of ENaC expression and function in the inner ear of pendrin knock-out mice as a perspective on the development of endolymphatic hydrops. [PDF]

PLoS ONE, 2014
Pendrin mutations cause enlarged vestibular aqueducts and various degrees of sensorineural hearing loss. The selective abolition of pendrin causes dilation of the membranous labyrinth known as endolymphatic hydrops, loss of the endocochlear potential ...
Bo Gyung Kim, Jin Young Kim, Hee Nam Kim, Jinwoong Bok, Wan Namkung, Jae Young Choi, Sung Huhn Kim   +6 more
doaj   +1 more source

Human Nasal and Bronchial Epithelium in Cystic Fibrosis: Differences in Expression of Airway pH Regulatory Proteins

Pediatric Pulmonology, Volume 61, Issue 8, August 2026.
ABSTRACT Background Decreased apical bicarbonate transport into the airway surface liquid (ASL) has been associated with decreased ASL pH, which can have adverse respiratory effects. However, the human CF epithelium can normalize ASL pH. Thus, we hypothesized that pH regulatory proteins other than the CFTR could be altered in the CF epithelium ...
Michael D. Davis, Laura Smith, Yi Zhao, Rania Abdul Rahman, Faiza Khalid, James Chmiel, Katie Boyne, Ivana A. Daniels, Benjamin Gaston, Nadzeya Marozkina   +9 more
wiley   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source