Results 31 to 40 of about 2,665 (161)

IL-17A induces Pendrin expression and chloride-bicarbonate exchange in human bronchial epithelial cells. [PDF]

PLoS ONE, 2014
The epithelium plays an active role in the response to inhaled pathogens in part by responding to signals from the immune system. Epithelial responses may include changes in chemokine expression, increased mucin production and antimicrobial peptide ...
Kelly M Adams, Valsamma Abraham, Daniel Spielman, Jay K Kolls, Ronald C Rubenstein, Gregory E Conner, Noam A Cohen, James L Kreindler   +7 more
doaj   +1 more source

Atypical Presentation of Enlarged Vestibular Aqueducts Caused by SLC26A4 Variants

Children, 2022
Enlarged vestibular aqueduct is the most common inner ear malformation in pediatric patients with sensorineural hearing loss. Here, we report a new presentation of enlarged vestibular aqueduct in a Korean family.
Jun Chul Byun, Kyu-Yup Lee, Su-Kyeong Hwang   +2 more
doaj   +1 more source

Modus operandi of ClC-K2 Cl⁻ Channel in the Collecting Duct Intercalated Cells

Biomolecules, 2023
The renal collecting duct is known to play a critical role in many physiological processes, including systemic water–electrolyte homeostasis, acid–base balance, and the salt sensitivity of blood pressure.
Anna Stavniichuk, Kyrylo Pyrshev, Viktor N. Tomilin, Mariya Kordysh, Oleg Zaika, Oleh Pochynyuk   +5 more
doaj   +1 more source

Two Compound Heterozygous Were Identified in Gene in Two Chinese Families With Enlarged Vestibular Aqueduct [PDF]

Clinical and Experimental Otorhinolaryngology, 2019
Objectives To investigate the genetic causes of hearing loss with enlarged vestibular aqueduct (EVA) in two children from unrelated two Chinese families. Methods Sanger sequencing of all coding exons in SLC26A4 (encoding Pendrin protein) was performed on
Yongbo Yu, Yang Yang, Jie Lu, Yaqiong Jin, Yeran Yang, Enyu Hong, Jin Shi, Feng Chen, Shujing Han, Ping Chu, Yongli Guo, Xin Ni   +11 more
doaj   +1 more source

Double Knockout of Carbonic Anhydrase II (CAII) and Na+-Cl- Cotransporter (NCC) Causes Salt Wasting and Volume Depletion

Cellular Physiology and Biochemistry, 2013
Background and Aims: The thiazide-sensitive Na+-Cl- cotransporter NCC and the Cl-/HCO3-exchanger pendrin are expressed on apical membranes of distal cortical nephron segments and mediate salt absorption, with pendrin working in tandem with the epithelial
Jie Xu, Sharon Barone, Mary-Beth Brooks, Manoocher Soleimani   +3 more
doaj   +1 more source

Non-syndromic enlarged vestibular aqueduct caused by novel compound mutations of the SLC26A4 gene: a case report and literature review

Frontiers in Genetics, 2023
Enlarged vestibular aqueduct is an autosomal genetic disease mainly caused by mutations in the SLC26A4 gene and includes non-syndromic and syndromic types.
Yunhua Huang, Yunhua Huang, Linlin Li, Linlin Li, Liqiu Pan, Liqiu Pan, Xiaoting Ling, Xiaoting Ling, Chenghan Wang, Chenghan Wang, Chaoyu Huang, Chaoyu Huang, Yifang Huang, Yifang Huang   +13 more
doaj   +1 more source

Correction: Lmx1a is essential for marginal cell differentiation and stria vascularis formation [PDF]

Frontiers in Cell and Developmental Biology
Justine M. Renauld, Igor Y. Iskusnykh, Ebenezer N. Yamoah, Richard J. H. Smith, Corentin Affortit, David Z. He, Huizhan Liu, David Nichols, Judith Bouma, Mahesh K. Nayak, Xin Weng, Tianli Qin, Mai Har Sham, Victor V. Chizhikov, Bernd Fritzsch   +14 more
doaj   +2 more sources

Pendrin stimulates a chloride absorption pathway to increase CFTR‐mediated chloride secretion from Cystic Fibrosis airway epithelia

FASEB BioAdvances, 2020
Cystic Fibrosis (CF), an inherited multi‐system disease, is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) that disrupt its ability to secrete anions from epithelia.
Jeffrey Bajko, Mei Duguid, Steve Altmann, Gregory D. Hurlbut, J. Stefan Kaczmarek   +4 more
doaj   +1 more source

TMED3 Complex Mediates ER Stress‐Associated Secretion of CFTR, Pendrin, and SARS‐CoV‐2 Spike

Advanced Science, 2022
Under ER stress conditions, the ER form of transmembrane proteins can reach the plasma membrane via a Golgi‐independent unconventional protein secretion (UPS) pathway. However, the targeting mechanisms of membrane proteins for UPS are unknown. Here, this
Hak Park, Soo Kyung Seo, Ju‐Ri Sim, Su Jin Hwang, Ye Jin Kim, Dong Hoon Shin, Dong Geon Jang, Shin Hye Noh, Pil‐Gu Park, Si Hwan Ko, Mi Hwa Shin, Jae Young Choi, Yukishige Ito, Chung‐Min Kang, Jae Myun Lee, Min Goo Lee   +15 more
doaj   +1 more source

Effect of acetazolamide on pendrin expression in rat kidney. The expression of pendrin and a. Expression of pendrin mRNA in animals treated with ACTZ.

, 2013
Expression of pendrin in animals treated with ACTZ for 6(lower panel). Results shown are representative of 2 separate studies examining 5 different rats from each treatment group. b. Pendrin expression in kidneys of rats treated with ACTZ.
Jie Xu (34477), Manoocher Soleimani (486415), Kamyar Zahedi (486413), Sharon Barone (486414)   +3 more
core   +1 more source