Results 11 to 20 of about 2,665 (161)

Ablation of the Cl-/HCO3- Exchanger Pendrin Enhances Hydrochlorothiazide-Induced Diuresis

Kidney & Blood Pressure Research, 2017
Background/Aims: The Cl-/HCO3- exchanger pendrin and the thiazide-sensitive Na-Cl cotransporter NCC are expressed in the kidney distal nephron and mediate salt absorption.
Saeed Alshahrani, Manoocher Soleimani
doaj   +2 more sources

Regulation of two renal chloride transporters, AE1 and pendrin, by electrolytes and aldosterone. [PDF]

PLoS ONE, 2013
The renal handling of salt and protons and bicarbonate are intricately linked through shared transport mechanisms for sodium, chloride, protons, and bicarbonate.
Nilufar Mohebbi, Angelica Perna, Jenny van der Wijst, Helen M Becker, Giovambattista Capasso, Carsten A Wagner   +5 more
doaj   +4 more sources

Contractile force is enhanced in Aortas from pendrin null mice due to stimulation of angiotensin II-dependent signaling. [PDF]

PLoS ONE, 2014
Pendrin is a Cl-/HCO3- exchanger expressed in the apical regions of renal intercalated cells. Following pendrin gene ablation, blood pressure falls, in part, from reduced renal NaCl absorption.
Roy L Sutliff, Erik R Walp, Young Hee Kim, Lori A Walker, Alexander M El-Ali, Jing Ma, Robert Bonsall, Semra Ramosevac, Douglas C Eaton, Jill W Verlander, Laura Hansen, Rudolph L Gleason, Truyen D Pham, Seongun Hong, Vladimir Pech, Susan M Wall   +15 more
doaj   +2 more sources

Pendrin, a Novel Transcriptional Target of the Uroguanylin System

Cellular Physiology and Biochemistry, 2013
Guanylin (GN) and uroguanylin (UGN) are low-molecular-weight peptide hormones produced mainly in the intestinal mucosa in response to oral salt load. GN and UGN (guanylin peptides) induce secretion of electrolytes and water in both intestine and kidney ...
Julia Rozenfeld, Osnat Tal, Orly Kladnitsky, Lior Adler, Edna Efrati, Stephen L. Carrithers, Seth L. Alper, Israel Zelikovic   +7 more
doaj   +2 more sources

The Human Pendrin Promoter Contains two N4 GAS Motifs with Different Functional Relevance

Cellular Physiology and Biochemistry, 2013
Background: Pendrin, an anion exchanger associated with the inner ear, thyroid and kidney, plays a significant role in respiratory tissues and diseases, where its expression is increased following IL-4 and IL-13 exposure.
Simone Vanoni, Charity Nofziger, Silvia Dossena, Selma M. Soyal, Wolfgang Patsch, Paolo Plevani, Albert Duschl, Markus Paulmichl   +7 more
doaj   +2 more sources

Co-Regulated Pendrin and Aquaporin 5 Expression and Trafficking in Type-B Intercalated Cells under Potassium Depletion [PDF]

Cellular Physiology and Biochemistry, 2013
Background: We recently reported that aquaporin 5 (AQP5), a water channel never identified in the kidney before, co-localizes with pendrin at the apical membrane of type-B intercalated cells in the kidney cortex.
Giuseppe Procino, Serena Milano, Grazia Tamma, Silvia Dossena, Claudia Barbieri, Maria Celeste Nicoletti, Marianna Ranieri, Annarita Di Mise, Charity Nofziger, Maria Svelto, Markus Paulmichl, Giovanna Valenti   +11 more
doaj   +3 more sources

Mechanism of anion exchange and small-molecule inhibition of pendrin [PDF]

Nature Communications
Pendrin (SLC26A4) is an anion exchanger that mediates bicarbonate (HCO3 −) exchange for chloride (Cl−) and is crucial for maintaining pH and salt homeostasis in the kidney, lung, and cochlea. Pendrin also exports iodide (I−) in the thyroid gland. Pendrin
Lie Wang, Anthony Hoang, Eva Gil-Iturbe, Arthur Laganowsky, Matthias Quick, Ming Zhou   +5 more
doaj   +2 more sources

Impaired Renal Base Excretion in Secretin Receptor Knock-Out Mice During Prolonged Base-Loading. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Secretin was recently found to play a pivotal role in the renal adaptation to acute base excess. Here, secretin increases pendrin‐dependent HCO3− secretion from the beta‐intercalated cells in the cortical collecting ducts. Whether secretin and its receptor play a role during prolonged base‐loading remains unknown.
Jensen T, Andersen JF, Trans LW, Modvig IM, Vitzthum H, Holst JJ, Hartman B, Svendsen SL, Sørensen MV, Leipziger J, Berg P.   +10 more
europepmc   +2 more sources

Low-Salt Diet Induces Claudin-3 Expression and Drives Adaptive Changes in Collecting Duct of Claudin-3-Deficient Mice. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Renal sodium reabsorption occurs through both transcellular and paracellular pathways. Tight junction proteins play a key role in mediating paracellular transport. The collecting duct is critical for the fine tuning of sodium balance and is highly responsive to changes in dietary salt intake.
Sassi A, Chassot A, Jellali S, Liaudet N, Polat A, Baier F, Stroka D, Furuse M, Feraille E.   +8 more
europepmc   +2 more sources

Prostaglandin-E2 Mediated Increase in Calcium and Phosphate Excretion in a Mouse Model of Distal Nephron Salt Wasting. [PDF]

PLoS ONE, 2016
Contribution of salt wasting and volume depletion to the pathogenesis of hypercalciuria and hyperphosphaturia is poorly understood. Pendrin/NCC double KO (pendrin/NCC-dKO) mice display severe salt wasting under basal conditions and develop profound ...
Manoocher Soleimani, Sharon Barone, Jie Xu, Saeed Alshahrani, Marybeth Brooks, Francis X McCormack, Roger D Smith, Kamyar Zahedi   +7 more
doaj   +1 more source