Results 21 to 30 of about 2,665 (161)

Regulation of renal pendrin activity by aldosterone

, 2021
PURPOSE OF REVIEW: Pendrin resides on the luminal membrane of type B intercalated cells in the renal collecting tubule system mediating the absorption of chloride in exchange for bicarbonate.
Bourgeois, Soline, Wagner, Carsten A; https://orcid.org/   +1 more
core   +1 more source

Pendrin: linking acid base to blood pressure

, 2023
International audiencePendrin (SLC26A4) is an anion exchanger from the SLC26 transporter family which is mutated in human patients affected by Pendred syndrome, an autosomal recessive disease characterized by sensoneurinal deafness and hypothyroidism ...
Chambrey, Régine, Picard, Nicolas, Eladari, Dominique, Brazier, François, Cornière, Nicolas   +4 more
core   +1 more source

Acute regulated expression of pendrin in human urinary exosomes [PDF]

, 2017
It is well known that pendrin, an apical Cl(-)/HCO3(-)exchanger in type B intercalated cells, is modulated by chronic acid-base disturbances and electrolyte intake.
Pathare, Ganesh Tukaram, Ganesh Pathare, Wagner, Carsten A, Neuhaus, Thomas J, Pathare, Ganesh, Dhayat, Nasser, Fuster, Daniel, Fuster, Daniel G, Mohebbi, Nilufar, Daniel G. Fuster, Wagner, Carsten, Cheval, Lydie, L, Wagner, Carsten A., Cheval, Lydie, Thomas J. Neuhaus, Nilufar Mohebbi, Cheval, Lydie,, Neuhaus, Thomas, Nasser Dhayat, Carsten A. Wagner, Fuster, Daniel Guido, Lydie Cheval, Neuhaus, Thomas J.   +22 more
core   +2 more sources

Interleukin-4 Induces CpG Site-Specific Demethylation of the Pendrin Promoter in Primary Human Bronchial Epithelial Cells

Cellular Physiology and Biochemistry, 2017
Pendrin is upregulated in bronchial epithelial cells following IL-4 stimulation via binding of STAT6 to an N4 GAS motif. Basal CpG methylation of the pendrin promoter is cell-specific.
Giada Scantamburlo, Simone Vanoni, Silvia Dossena, Selma M. Soyal, Emanuele Bernardinelli, Davide Antonio Civello, Wolfgang Patsch, Markus Paulmichl, Charity Nofziger   +8 more
doaj   +1 more source

The anion exchanger pendrin (SLC26A4) and renal acid-base homeostasis [PDF]

, 2011
The anion exchanger pendrin (Pds, SLC26A4) transports various anions including bicarbonate, chloride and iodide. In the kidney, pendrin is exclusively expressed on the luminal pole of bicarbonate-secretory type B intercalated cells.
Nilufar Mohebbi, Geibel JP, Mohebbi N, Wagner, Carsten A; https://orcid.org/, Giovambattista Capasso, Capasso, G, CAPASSO, Giovambattista, John P. Geibel, Carsten A. Wagner, Wagner CA   +9 more
core   +1 more source

Renal intercalated cells and blood pressure regulation

Kidney Research and Clinical Practice, 2017
Type B and non-A, non-B intercalated cells are found within the connecting tubule and the cortical collecting duct. Of these cell types, type B intercalated cells are known to mediate Cl⁻ absorption and HCO₃⁻ secretion largely through pendrin-dependent ...
Susan M. Wall
doaj   +1 more source

Developmental Expression of Membrane Pumps and Ion Channels in Human Vestibular Endolymph Homeostasis. [PDF]

Dev Neurobiol
ABSTRACT The expression patterns of key membrane pumps and ion channels involved in endolymph cycling have been studied in the rodent inner ear and the developing and adult human cochlea. However, little is known about their expression during the development of the human vestibular system.
van Beelen ESA, van der Valk WH, de Groot JCMJ, van Benthem PPG, Locher H.   +4 more
europepmc   +2 more sources

Effect of Known Inhibitors of Ion Transport on Pendrin (SLC26A4) Activity in a Human Kidney Cell Line

Cellular Physiology and Biochemistry, 2016
Background/Aims: Pendrin is a Cl-/I-/HCO3- exchanger playing a fundamental role in controlling blood pressure and airway function, therefore representing an attractive target for the treatment of hypertensive states and respiratory distresses.
Emanuele Bernardinelli, Roberta Costa, Charity Nofziger, Markus Paulmichl, Silvia Dossena   +4 more
doaj   +1 more source

DNAJC14 Ameliorates Inner Ear Degeneration in the DFNB4 Mouse Model

Molecular Therapy: Methods & Clinical Development, 2020
The His723Arg (H723R) mutation in SLC26A4, encoding pendrin, is the most prevalent mutation in East Asia, resulting in DFNB4, an autosomal recessive type of genetic hearing loss.
Hye Ji Choi, Hyun Jae Lee, Jin Young Choi, Ik Hyun Jeon, Byunghwa Noh, Sushil Devkota, Han-Woong Lee, Seong Kug Eo, Jae Young Choi, Min Goo Lee, Jinsei Jung   +10 more
doaj   +1 more source

Branchial localization of acid (A-type) and base (B-type) excreting ionocytes in Amazonian stenohaline freshwater Potamotrygon ray. [PDF]

J Fish Biol
Abstract The branchial epithelium of Potamotrygon—a member of the only strictly freshwater elasmobranch family Potamotrygonidae—was observed via immunohistochemistry, and two distinct forms of ionocytes were identified. The acid (A‐type) and base (B‐type) secreting cells with respective basolateral–apical localizations of Na+/K+‐ATPase–Na+/H+ exchanger
Rossi MW, Wood CM, Val AL, Wilson JM.
europepmc   +2 more sources