Results 1 to 10 of about 2,665 (161)

Expression of Pendrin Periostin in Allergic Rhinitis Chronic Rhinosinusitis [PDF]

Allergology International, 2012
Background: : Pendrin and periostin are newly identified mediators of the inflammatory process. The expression of these proteins in human sinonasal tissue and their roles in allergic rhinitis and chronic rhinosinusitis remain to be elucidated. This study
Yusuke Suzuki, Kenji Izuhara, Seiji Kakehata   +2 more
exaly   +4 more sources

Pendrin inhibition is associated with protective effect of prone positioning in a ventilator-induced lung injury mouse model [PDF]

Scientific Reports
Pendrin (SLC26A4), a transmembrane anion exchanger, is upregulated in inflammatory airway diseases. In this study, we analyzed the role of pendrin expression in a ventilator-induced acute lung injury (VILI) animal model. VILI was induced in the supine or
Jae Young Choi, Wan Namkung, Moo Suk Park   +2 more
exaly   +3 more sources

Functional interplay between CFTR and pendrin: physiological and pathophysiological relevance [PDF]

Frontiers in Bioscience-Landmark, 2022
The transport of chloride and bicarbonate across epithelia controls the pH and volume of the intracellular and luminal fluids, as well as the systemic pH and vascular volume.
Grazia Tamma, Silvia Dossena
doaj   +2 more sources

The comparison of two pendrin inhibitors, YS-01 and PDSinh-C01, in lipopolysaccharide-induced acute lung injury [PDF]

Scientific Reports
Acute respiratory distress syndrome (ARDS) is a life-threatening condition without specific treatments, relying on mechanical ventilation and supportive care.
Hyeon Kyu Choi, Ji Young Son, Mi Hwa Shin, Jinhong Park, Doona Song, Young-Min Hyun, Ji-Hwan Ryu, Je Kyung Seong, Gyoonhee Han, Wan Namkung, Chul Hoon Kim, Jae Young Choi, Moo Suk Park   +12 more
doaj   +2 more sources

Loss of OXGR1 function uncouples intrarenal RAS activation from pendrin and αENaC regulation and blunts angiotensin II-induced hypertension [PDF]

Frontiers in Pharmacology
BackgroundActivation of the intrarenal renin–angiotensin system (RAS) is a key mechanism driving sodium retention and hypertension. In the distal nephron, locally generated angiotensin II (Ang II) promotes Na+ reabsorption through coordinated regulation ...
Pilar Cárdenas, Juan Castillo-Geraldo, Lilian Caroline Gonçalves de Oliveira, Nicolas Muñoz, Rodrigo Yokota, Marina de Moura Bello, Gabriel Joo-Mulsow, Luis Michea, Dulce Elena Casarini, Alexis A. Gonzalez, Alexis A. Gonzalez   +10 more
doaj   +2 more sources

Lmx1a is essential for marginal cell differentiation and stria vascularis formation [PDF]

Frontiers in Cell and Developmental Biology
The transcription factor Lmx1a is widely expressed during early inner ear development, and mice lacking Lmx1a expression exhibit fusion of cochlear and vestibular hair cells and fail to form the ductus reuniens and the endolymphatic sac.
Justine M. Renauld, Igor Y. Iskusnykh, Ebenezer N. Yamoah, Richard J. H. Smith, Corentin Affortit, David Z. He, Huizhan Liu, David Nichols, Judith Bouma, Mahesh K. Nayak, Xin Weng, Tianli Qin, Mai Har Sham, Victor V. Chizhikov, Bernd Fritzsch   +14 more
doaj   +2 more sources

Metabolic alkalosis in cystic fibrosis: from vascular volume depletion to impaired bicarbonate excretion [PDF]

Frontiers in Endocrinology
Cystic fibrosis (CF) is the most common life-threatening genetic disease in the United States and among people of European descent. Despite the widespread distribution of the cystic fibrosis transmembrane conductance regulator (CFTR) along kidney tubules,
Manoocher Soleimani, Manoocher Soleimani
doaj   +2 more sources

Activation of 2‐oxoglutarate receptor 1 (OXGR1) by α‐ketoglutarate (αKG) does not detectably stimulate Pendrin‐mediated anion exchange in Xenopus oocytes

Physiological Reports, 2022
SLC26A4/Pendrin is the major electroneutral Cl−/HCO3− exchanger of the apical membrane of the Type B intercalated cell (IC) of the connecting segment (CNT) and cortical collecting duct (CCD).
John F. Heneghan, Amar J. Majmundar, Alicia Rivera, Jay G. Wohlgemuth, Jeffrey S. Dlott, L. Michael Snyder, Friedhelm Hildebrandt, Seth L. Alper   +7 more
doaj   +1 more source

Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger

Nature Communications, 2023
Pendrin (SLC26A4) is an anion exchanger expressed in the apical membranes of selected epithelia. Pendrin ablation causes Pendred syndrome, a genetic disorder associated with sensorineural hearing loss, hypothyroid goiter, and reduced blood pressure ...
Qianying Liu, Xiang Zhang, Hui Huang, Yuxin Chen, Fang Wang, Aihua Hao, Wuqiang Zhan, Qiyu Mao, Yuxia Hu, Lin Han, Yifang Sun, Meng Zhang, Zhimin Liu, Geng-Lin Li, Weijia Zhang, Yilai Shu, Lei Sun, Zhenguo Chen   +17 more
doaj   +1 more source

Identification of IQGAP1 as a SLC26A4 (Pendrin)-Binding Protein in the Kidney

Frontiers in Molecular Biosciences, 2022
Background: Several members of the SLC26A family of transporters, including SLC26A3 (DRA), SLC26A5 (prestin), SLC26A6 (PAT-1; CFEX) and SLC26A9, form multi-protein complexes with a number of molecules (e.g., cytoskeletal proteins, anchoring or adaptor ...
Jie Xu, Jie Xu, Sharon Barone, Sharon Barone, Sharon Barone, Mujan Varasteh Kia, L. Shannon Holliday, Kamyar Zahedi, Kamyar Zahedi, Kamyar Zahedi, Manoocher Soleimani, Manoocher Soleimani, Manoocher Soleimani   +12 more
doaj   +1 more source