Results 101 to 110 of about 243,101 (317)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Sustainable assessment of structures and materials using ground penetrating radar (GPR)

open access: yes, 2015
Ground penetrating radar (GPR) is a non-destructive, non-invasive device that can be used to investigate materials in buildings, structures and the ground.
Evans, R
core  

SCARA Involvement in the Uptake of Nanoparticles Formed by Cell-Penetrating Peptides

open access: yes, 2015
The investigation of uptake mechanisms for cell-penetrating peptides (CPPs) is and has been an ongoing project for as long as the peptides have been known, a time period that now spans over two decades.
Staffan Lindberg   +5 more
core   +1 more source

Diagnostic problems and emergency cardiac surgery in cut-like penetrating cardiac trauma

open access: yes, 2021
Penetrating cardiothoracic injuries have occurred in large numbers throughout the world from ancient times to the present. A small percentage of them, but the most severe, are penetrating cardiac traumas.
Bartuś, Krzysztof   +11 more
core   +1 more source

Craniofacial impalement injury: Projectile fragment to the head

open access: yesArchives of Trauma Research, 2018
Circular saws and angle grinders are two of the most dangerous pieces of electrical equipment on a worksite. Besides the danger that any high-powered, sharp piece of equipment possesses, these pieces use circular saw blades that can splinter into ...
Celia Y Quang   +5 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Anesthetic Management of Penetrating Tracheal Injury in a 3-Year-Old Child: A Case Report

open access: yesAnnals of Cardiac Anaesthesia
Penetrating tracheal injuries in children are uncommon and present significant diagnostic and airway challenges. We report the case of a 3-year-old boy who sustained an accidental penetrating neck trauma and was taken up for tracheal repair.
Malik Indira   +5 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

PENETRATING WOUNDS: PENETRATING ABDOMINAL TRAUMA AND PENETRATING EXTREMITY WOUNDS

open access: yesEPRA International Journal of Multidisciplinary Research (IJMR)
Introduction: This article provides a review of penetrating injuries to the extremities and abdomen. Extremity injuries require early attention to avoid limb loss, with factors such as soft tissue, nerve and bone damage determining the feasibility of saving the limb. In abdominal trauma, the most common causes are stab wounds and gunshot wounds, mainly
null David Patricio Rojas Márquez   +7 more
openaire   +1 more source

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