Results 91 to 100 of about 563,263 (296)

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

[Review of] Alexandru Moscu (Director/Co-Producer) and Joel Geyer (Writer/Co-Producer). In Search of Freedom: Nebraskans from Latvia [PDF]

, 1988
Alexandru Moscu and Joel Geyer have produced a program which provides many penetrating insights into the dimensions of ethnicity in the United States. Furthermore they packaged the program in a manner which is not only instructive but also emotionally ...
Gradwohl, David M.
core   +1 more source

CHANTI: a Fast and Efficient Charged Particle Veto Detector for the NA62 Experiment at CERN

, 2015
The design, construction and test of a charged particle detector made of scintillation counters read by Silicon Photomultipliers (SiPM) is described. The detector, which operates in vacuum and is used as a veto counter in the NA62 experiment at CERN, has
Ambrosino, F., Capussela, T., Corradi, G., Di Filippo, D., Massarotti, P., Mirra, M., Napolitano, M., Paglia, U., Palladino, V., Roscilli, L., Saracino, G., Tagnani, D., Vanzanella, A.   +12 more
core   +1 more source

PENETRATING WOUNDS: PENETRATING ABDOMINAL TRAUMA AND PENETRATING EXTREMITY WOUNDS

EPRA International Journal of Multidisciplinary Research (IJMR)
Introduction: This article provides a review of penetrating injuries to the extremities and abdomen. Extremity injuries require early attention to avoid limb loss, with factors such as soft tissue, nerve and bone damage determining the feasibility of saving the limb. In abdominal trauma, the most common causes are stab wounds and gunshot wounds, mainly
null David Patricio Rojas Márquez, null José Luis Rea Moscoso, null Cristian Ricardo Prado Sanchez, null Pilar Alejandra Parreño Castillo, null Christian David Tacuri Calle, null John Carlos Chona Serrano, null Ciboney Scarleth Gaibor Moyano, null Bryam Esteban Coello García   +7 more
openaire   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Injury to the Temporal Lobe via Medial Transorbital Entry of a Toothbrush

Journal of Neurological Surgery Reports, 2013
Objectives Intracranial penetration by foreign bodies entering via the orbit represent an unusual form of traumatic brain injury. Nevertheless, much is at stake with high risk for cranial nerve and neurovascular injury.
Jesse Skoch, Tracy L. Ansay, G. M. Lemole   +2 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Aorto-esophageal fistula secondary to penetrating atherosclerotic ulcer

Journal of Emergencies, Trauma and Shock, 2012
Aorto-esophageal fistula (AEF) is a rare and life threatening condition, which can be rapidly fatal. More than half of such cases are secondary to aortic aneurysm rupture.
Ranjana Gupta, Puneet Mittal, Gaurav Mittal   +2 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source