Results 41 to 50 of about 391,647 (282)

Lorlatinib‐Containing Therapy for MYCN‐Amplified, ALK‐Mutated Neuroblastoma With Bulky Leptomeningeal Relapse: A Case Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Central nervous system (CNS) relapse of neuroblastoma carries a poor prognosis, and craniospinal irradiation (CSI) poses substantial long‐term toxicity in young children. We report a toddler with MYCN‐amplified neuroblastoma harboring somatic ALK R1275Q who developed extensive leptomeningeal relapse with paraplegia.
Jinwoo Kim, Minji Kim, Nani Jung, Sung Eun Kim, Ji Yoon Kim, Mi Ae Chu, Jung Eun Kwon, Yeo Hyang Kim, So Mi Lee, Ki‐Su Park, Jeong Eun Lee, Ye Jee Shim   +11 more
wiley   +1 more source

Deep Eutectic Systems as Novel Vehicles for Assisting Drug Transdermal Delivery

Pharmaceutics, 2022
In recent years, deep eutectic systems (DES) emerged as novel vehicles for facilitating the transdermal delivery of various drugs, including polysaccharides, proteins, insulin, vaccine, nanoparticles, and herb extracts.
Jinbao Wang, Mingjian Li, Langhuan Duan, Yameng Lin, Xiuming Cui, Ye Yang, Chengxiao Wang   +6 more
doaj   +1 more source

Skin penetration enhancement

Journal of Dermatological Treatment, 1994
One of the major problems in delivering drugs via the dermal route is the very effective barrier function of the skin. The reason for the barrier function can be attributed to the intercellular lipids of the stratum corneum. They are arranged into bilayer arrays and a penetrating drug has to be soluble in them and then transfer sequentially from a ...
J. Hadgraft, Ka Walters
openaire   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Penetration enhancer-containing vesicles: composition dependence of structural features and skin penetration ability

, 2012
In this work, we focused on how composition and preparation method of vesicles might affect their morphological features and delivery performances. Penetration Enhancer-containing Vesicles, PEVs, vesicles containing a water miscible penetration enhancer (
SINICO, CHIARA, MOSTALLINO, MARIA CRISTINA, VALENTI, DONATELLA, LAMPIS, SANDRINA, FADDA, ANNA MARIA, MANCONI, MARIA, MONDUZZI, MAURA, CADDEO, CARLA, Lampis S, Mostallino MC, Fadda AM, Caddeo C, Valenti D, Monduzzi M, Manconi M, Sinico C   +15 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Therapeutic and cosmeceutical potential of ethosomes: An overview

Journal of Advanced Pharmaceutical Technology & Research, 2010
The main disadvantage of transdermal drug delivery is the poor penetration of most compounds into the human skin. The main barrier of the skin is located within its uppermost layer, the stratum corneum (SC).
Poonam Verma, K Pathak
doaj   +1 more source

2H NMR evidence for dynamic disorder in human skin induced by the penetration enhancer azone [PDF]

, 1996
Penetration enhancers mediate trans-dermal drug delivery. The penetration enhancer dodecyl-azacycloheptanone (Azone(R)) was characterized in situ with H-2 NMR on human stratum corneum treated with either uniformly deuterated Azone(R) or penetration ...
Marttin, E., Roemelé, P.E.H., Bezema, F.R., Groot, H.J.M. de, Boddé, H.E., Brussee, J., F.R. Bezema, P.E.H. Roemelé, E. Marttin, H.J.M. de Groot, J. Brussee, H.E. Boddé   +11 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Molecular interactions between the penetration enhancer 1,8-cineole and human skin

, 2006
Penetration enhancers are chemicals that temporarily and reversibly diminish the barrier function of the outermost layer of skin, the stratum corneum, to facilitate drug delivery to and through the tissue.
H. G. M. Edwards, B. W. Barry, E. E. Lawson, A. C. Williams, Edwards, H. G. M., Lawson, E. E., Barry, B. W., Williams, A. C.   +7 more
core   +1 more source