Results 11 to 20 of about 399,815 (205)

Morphogenetic penicillin-binding proteins control virulence-associated type III secretion systems in Salmonella [PDF]

Infection and Immunity
Type III protein secretion systems (T3SSs) function as multiprotein devices that span the envelope of Gram-negative bacteria using the peptidoglycan (PG) layer as scaffold.
Sónia Castanheira, Sara Torronteras, Juan J. Cestero, Francisco García-del Portillo   +3 more
doaj   +2 more sources

Dynamical Behavior of β-Lactamases and Penicillin- Binding Proteins in Different Functional States and Its Potential Role in Evolution [PDF]

Entropy, 2019
β-Lactamases are enzymes produced by bacteria to hydrolyze β-lactam-based antibiotics, and pose serious threat to public health through related antibiotic resistance.
Feng Wang, Hongyu Zhou, Xinlei Wang, Peng Tao   +3 more
doaj   +2 more sources

Weaknesses out of strength: PNA against the penicillin-binding proteins [PDF]

Molecular Therapy: Nucleic Acids
Mateusz Wdowiak
doaj   +2 more sources

Predicting β-lactam susceptibility from the genome of Streptococcus pneumoniae and other mitis group streptococci

Frontiers in Microbiology, 2023
IntroductionFor Streptococcus pneumoniae, β-lactam susceptibility can be predicted from the amino acid sequence of the penicillin-binding proteins PBP1a, PBP2b, and PBP2x.
Helle Brander Eriksen, Kurt Fuursted, Anders Jensen, Christian Salgård Jensen, Xiaohui Nielsen, Xiaohui Nielsen, Jens Jørgen Christensen, Jens Jørgen Christensen, Patricia Shewmaker, Ana Rita Rebelo, Frank Møller Aarestrup, Kristian Schønning, Hans-Christian Slotved, the One Day in Denmark (ODiD) Consortium   +13 more
doaj   +1 more source

New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria. [PDF]

PLoS ONE, 2011
BACKGROUND: Penicillin-binding proteins (PBPs) are well known and validated targets for antibacterial therapy. The most important clinically used inhibitors of PBPs β-lactams inhibit transpeptidase activity of PBPs by forming a covalent penicilloyl ...
Samo Turk, Olivier Verlaine, Thomas Gerards, Matej Zivec, Jan Humljan, Izidor Sosič, Ana Amoroso, Astrid Zervosen, André Luxen, Bernard Joris, Stanislav Gobec   +10 more
doaj   +1 more source

Genetic characterization of penicillin-binding proteins of nonencapsulated Streptococcus pneumoniae in the postpneumococcal conjugate vaccine era in Japan

International Journal of Infectious Diseases, 2022
Objectives: Nonencapsulated Streptococcus pneumoniae (NESp) is emerging after the introduction of pneumococcal conjugate vaccines (PCVs). This study aimed to elucidate the genetic characteristics of penicillin-binding proteins (PBPs; PBP1a, 2b, and 2x ...
Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Kenji Kudo, Masahiko Ito, Satoshi Habadera, Nobumichi Kobayashi   +6 more
doaj   +1 more source

Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria

Biomolecules, 2021
Novel antimicrobial strategies are urgently required because of the rising threat of multi drug resistant bacterial strains and the infections caused by them.
Stefan Freischem, Immanuel Grimm, Arancha López-Pérez, Dieter Willbold, Burkhard Klenke, Cuong Vuong, Andrew J. Dingley, Oliver H. Weiergräber   +7 more
doaj   +1 more source

Construction and Activity Testing of a Modular Fusion Peptide against Enterococcus faecalis

Antibiotics, 2023
The emergence of antibiotic resistance in enterococci is a great concern encountered worldwide. Almost all enterococci exhibit significant levels of resistance to penicillin, ampicillin, semi-synthetic penicillin and most cephalosporins, primarily due to
Salim Manoharadas, Mohammad Altaf, Naushad Ahmad, Abdulwahed Fahad Alrefaei, Basel F. Al-Rayes   +4 more
doaj   +1 more source

Classification of Beta-lactamases and penicillin binding proteins using ligand-centric network models. [PDF]

PLoS ONE, 2015
β-lactamase mediated antibiotic resistance is an important health issue and the discovery of new β-lactam type antibiotics or β-lactamase inhibitors is an area of intense research.
Hakime Öztürk, Elif Ozkirimli, Arzucan Özgür   +2 more
doaj   +1 more source

Penicillin-Binding Protein 1 (PBP1) of Staphylococcus aureus Has Multiple Essential Functions in Cell Division

mBio, 2022
Bacterial cell division is a complex process requiring the coordination of multiple components to allow the appropriate spatial and temporal control of septum formation and cell scission. Peptidoglycan (PG) is the major structural component of the septum,
Katarzyna Wacnik, Vincenzo A. Rao, Xinyue Chen, Lucia Lafage, Manuel Pazos, Simon Booth, Waldemar Vollmer, Jamie K. Hobbs, Richard J. Lewis, Simon J. Foster   +9 more
doaj   +1 more source