Penicillin-binding proteins exhibit functional redundancy during asymmetric cell division in Clostridioides difficile [PDF]
Journal of BacteriologyPeptidoglycan synthesis is an essential driver of bacterial growth and division. The final steps of this crucial process involve the polymerization of glycan strands by shape, elongation, division, and sporulation (SEDS) family glycosyltransferases and ...
Shailab Shrestha +4 more
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Morphogenetic penicillin-binding proteins control virulence-associated type III secretion systems in Salmonella [PDF]
Infection and ImmunityType III protein secretion systems (T3SSs) function as multiprotein devices that span the envelope of Gram-negative bacteria using the peptidoglycan (PG) layer as scaffold.
Sónia Castanheira +3 more
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Dynamical Behavior of β-Lactamases and Penicillin- Binding Proteins in Different Functional States and Its Potential Role in Evolution [PDF]
Entropy, 2019 β-Lactamases are enzymes produced by bacteria to hydrolyze β-lactam-based antibiotics, and pose serious threat to public health through related antibiotic resistance.
Feng Wang +3 more
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Weaknesses out of strength: PNA against the penicillin-binding proteins [PDF]
Molecular Therapy: Nucleic AcidsMateusz Wdowiak
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Penicillin-binding proteins and β-lactam resistance [PDF]
FEMS Microbiology Reviews, 2008 A number of ways and means have evolved to provide resistance to eubacteria challenged by beta-lactams. This review is focused on pathogens that resist by expressing low-affinity targets for these antibiotics, the penicillin-binding proteins (PBPs). Even within this narrow focus, a great variety of strategies have been uncovered such as the acquisition
André Zapun +2 more
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Comparison of Bioorthogonal β‐Lactone Activity‐Based Probes for Selective Labeling of Penicillin‐Binding Proteins [PDF]
ChemBioChem, 2021 Nathaniel W Brown +2 more
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Frontiers in Microbiology, 2023 IntroductionFor Streptococcus pneumoniae, β-lactam susceptibility can be predicted from the amino acid sequence of the penicillin-binding proteins PBP1a, PBP2b, and PBP2x.
Helle Brander Eriksen +13 more
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New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria. [PDF]
PLoS ONE, 2011 BACKGROUND: Penicillin-binding proteins (PBPs) are well known and validated targets for antibacterial therapy. The most important clinically used inhibitors of PBPs β-lactams inhibit transpeptidase activity of PBPs by forming a covalent penicilloyl ...
Samo Turk +10 more
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International Journal of Infectious Diseases, 2022 Objectives: Nonencapsulated Streptococcus pneumoniae (NESp) is emerging after the introduction of pneumococcal conjugate vaccines (PCVs). This study aimed to elucidate the genetic characteristics of penicillin-binding proteins (PBPs; PBP1a, 2b, and 2x ...
Mitsuyo Kawaguchiya +6 more
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Kinetics of penicillin binding to penicillin-binding proteins of Staphylococcus aureus [PDF]
Biochemical Journal, 1994 Reduced affinity of penicillin-binding proteins (PBPs) for binding penicillin has been proposed as a mechanism of beta-lactam antibiotic resistance in staphylococci. Penicillin binding by PBPs of three penicillin-susceptible and two penicillin-resistant strains of Staphylococcus aureus was studied in kinetic assays to determine rate constants, drug ...
H F, Chambers +2 more
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