Two distinct penicillin binding proteins promote cell division in different Salmonella lifestyles [PDF]
Microbial Cell, 2018 The bacterial cell wall preserves cell integrity in response to external insults and the internal turgor pressure. The major component of the cell wall is the peptidoglycan (PG); a giant macromolecule formed by glycan chains cross-linked by short ...
Sónia Castanheira +3 more
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Penicillin-binding proteins of bdellovibrios [PDF]
Journal of Bacteriology, 1988 We examined the predacious gram-negative bacterium Bdellovibrio bacteriovorous 109J and free-living strains 109J-A1 and 109J-KA1 derived therefrom for penicillin-binding proteins (PBPs). We compared their PBPs with those of the host bacterium, Escherichia coli, and with those of a facultatively predacious bdellovibrio, B. stolpii UKi2, grown axenically.
J T, Park, S, Mahadevan
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Restricted Sequence Variation in
mSphere, 2020 A recent clinical report has linked Streptococcus pyogenes β-lactam antibiotic resistance to mutation in the penicillin binding protein (PBP) PBP2x. To determine whether this is an isolated case or reflects a broader prevalence of mutations that might ...
Andrew Hayes +4 more
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Relationship between Penicillin-Binding Proteins Alterations and β-Lactams Non-Susceptibility of Diseased Pig-Isolated Streptococcus suis [PDF]
Antibiotics, 2023 Streptococcus suis is a zoonotic pathogen causing disease in both animals and humans, and the emergence of increasingly resistant bacteria to antimicrobial agents has become a significant challenge globally. The objective of this study was to investigate
Kamonwan Lunha +5 more
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Penicillin-Binding Proteins in Streptococcus agalactiae and Their Association with Reduced Penicillin Susceptibility: An Overview [PDF]
AntibioticsStreptococcus agalactiae are bacteria that can cause a range of infections, some of them life-threatening. Currently, antimicrobial resistance has become a global problem that puts public health at risk.
Leonardo Nagao Ferreira +3 more
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Penicillin Binding Proteins and β-Lactamases of Mycobacterium tuberculosis: Reexamination of the Historical Paradigm [PDF]
mSphere, 2022 Penicillin binding proteins (PBPs) have been extensively studied due to their importance to the physiology of bacterial cell wall peptidoglycan and as targets of the most widely used class of antibiotics, the β-lactams. The existing paradigm asserts that
Gaurav Kumar +4 more
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Penicillin-Binding Proteins in Leptospira interrogans [PDF]
Antimicrobial Agents and Chemotherapy, 2001 ABSTRACT The Leptospira interrogans ponA and pbpB genes were isolated and characterized. ponA and pbpB encode the penicillin-binding proteins (PBPs) 1 and 3, respectively.
Brenot, A +3 more
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Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins [PDF]
eLife, 2021 Peptidoglycan is an essential component of the bacterial cell envelope that surrounds the cytoplasmic membrane to protect the cell from osmotic lysis. Important antibiotics such as β-lactams and glycopeptides target peptidoglycan biosynthesis.
Víctor M Hernández-Rocamora +5 more
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Antibacterial activities of novel peptide nucleic acids targeting Salmonella penicillin-binding proteins [PDF]
Molecular Therapy: Nucleic AcidsSalmonella is a significant global enteric pathogen with a high incidence of multidrug resistance (MDR), which limits therapeutic options and necessitates the development of novel treatments. Antisense peptide nucleic acids (PNAs), which target essential
Mohamed El-Fateh +4 more
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Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of
Gut Pathogens, 2009 While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria ...
Van de Velde Sébastien +5 more
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