Results 21 to 30 of about 401,752 (293)

Kinetics of penicillin binding to penicillin-binding proteins of Staphylococcus aureus [PDF]

Biochemical Journal, 1994
Reduced affinity of penicillin-binding proteins (PBPs) for binding penicillin has been proposed as a mechanism of beta-lactam antibiotic resistance in staphylococci. Penicillin binding by PBPs of three penicillin-susceptible and two penicillin-resistant strains of Staphylococcus aureus was studied in kinetic assays to determine rate constants, drug ...
H F, Chambers, M J, Sachdeva, C J, Hackbarth   +2 more
openaire   +2 more sources

Genetic characterization of penicillin-binding proteins of nonencapsulated Streptococcus pneumoniae in the postpneumococcal conjugate vaccine era in Japan

International Journal of Infectious Diseases, 2022
Objectives: Nonencapsulated Streptococcus pneumoniae (NESp) is emerging after the introduction of pneumococcal conjugate vaccines (PCVs). This study aimed to elucidate the genetic characteristics of penicillin-binding proteins (PBPs; PBP1a, 2b, and 2x ...
Mitsuyo Kawaguchiya, Noriko Urushibara, Meiji Soe Aung, Kenji Kudo, Masahiko Ito, Satoshi Habadera, Nobumichi Kobayashi   +6 more
doaj   +1 more source

Penicillin-binding proteins in bacteria [PDF]

Antimicrobial Agents and Chemotherapy, 1980
The penicilllin-binding proteins (PBPs) of several gram-positive and gram-negative bacteria have been examined. The results indicate that: (i) PBPs are membrane proteins with molecular weights ranging from 40,000 to 120,000. When extracted with Triton X-100 from sonicated cells, they appear to fall into two patterns: one found in rods and the other in ...
N H, Georgopapadakou, F Y, Liu
openaire   +2 more sources

Interaction Mode of the Novel Monobactam AIC499 Targeting Penicillin Binding Protein 3 of Gram-Negative Bacteria

Biomolecules, 2021
Novel antimicrobial strategies are urgently required because of the rising threat of multi drug resistant bacterial strains and the infections caused by them.
Stefan Freischem, Immanuel Grimm, Arancha López-Pérez, Dieter Willbold, Burkhard Klenke, Cuong Vuong, Andrew J. Dingley, Oliver H. Weiergräber   +7 more
doaj   +1 more source

Construction and Activity Testing of a Modular Fusion Peptide against Enterococcus faecalis

Antibiotics, 2023
The emergence of antibiotic resistance in enterococci is a great concern encountered worldwide. Almost all enterococci exhibit significant levels of resistance to penicillin, ampicillin, semi-synthetic penicillin and most cephalosporins, primarily due to
Salim Manoharadas, Mohammad Altaf, Naushad Ahmad, Abdulwahed Fahad Alrefaei, Basel F. Al-Rayes   +4 more
doaj   +1 more source

Penicillin-binding proteins of protoplast and sporoplast membranes of Streptomyces griseus strains [PDF]

, 1988
Membrane-bound penicillin-binding proteins (PBPs) of two Streptomyces griseus strains that sporulate well in liquid and solid medium have been investigated during the course of their life-cycle.
Szabó, István,, Harder, Wim,, Harder, Willem, Veenhuis, Marten,, Barabás, György,, Barabás, Judit,, Veenhuis, Marten, Barabás, Judit, Barabás, György, Szabó, István   +9 more
core   +1 more source

Surfactant-free purification of membrane protein complexes from bacteria: application to the staphylococcal penicillin-binding protein complex PBP2/PBP2a. [PDF]

, 2014
Surfactant-mediated removal of proteins from biomembranes invariably results in partial or complete loss of function and disassembly of multi-protein complexes. We determined the capacity of styrene-co-maleic acid (SMA) co-polymer to remove components of
Taylor, Peter W, Paulin, S, Roper, David I, Garcia-Lara, J, Roper, DI, Taylor, PW, Galley, Nicola F., Paulin, Sarah, Rosado, H, Foster, SJ, Taylor, Peter W., Dafforn, TR, Dafforn, Tim, Dafforn, Timothy R, Galley, Nicola F, Jamshad, Mohammed, Rosado, Helena, Foster, Simon J, Garcia-Lara, Jorge, Jamshad, M, Galley, NF, Foster, Simon J., Roper, David I.   +22 more
core   +1 more source

Classification of Beta-lactamases and penicillin binding proteins using ligand-centric network models. [PDF]

PLoS ONE, 2015
β-lactamase mediated antibiotic resistance is an important health issue and the discovery of new β-lactam type antibiotics or β-lactamase inhibitors is an area of intense research.
Hakime Öztürk, Elif Ozkirimli, Arzucan Özgür   +2 more
doaj   +1 more source

Penicillin-Binding Protein 1 (PBP1) of Staphylococcus aureus Has Multiple Essential Functions in Cell Division

mBio, 2022
Bacterial cell division is a complex process requiring the coordination of multiple components to allow the appropriate spatial and temporal control of septum formation and cell scission. Peptidoglycan (PG) is the major structural component of the septum,
Katarzyna Wacnik, Vincenzo A. Rao, Xinyue Chen, Lucia Lafage, Manuel Pazos, Simon Booth, Waldemar Vollmer, Jamie K. Hobbs, Richard J. Lewis, Simon J. Foster   +9 more
doaj   +1 more source

A CozE Homolog Contributes to Cell Size Homeostasis of Streptococcus pneumoniae

mBio, 2020
Control of peptidoglycan assembly is critical to maintain bacterial cell size and morphology. Penicillin-binding proteins (PBPs) are crucial enzymes for the polymerization of the glycan strand and/or their cross-linking via peptide branches.
Gro Anita Stamsås, Marine Restelli, Adrien Ducret, Céline Freton, Pierre Simon Garcia, Leiv Sigve Håvarstein, Daniel Straume, Christophe Grangeasse, Morten Kjos   +8 more
doaj   +1 more source