Results 1 to 10 of about 3,838 (150)
A single Sfp-type phosphopantetheinyl transferase plays a major role in the biosynthesis of PKS and NRPS derived metabolites in Streptomyces ambofaciens ATCC23877. [PDF]
PLoS ONE, 2014 The phosphopantetheinyl transferases (PPTases) are responsible for the activation of the carrier protein domains of the polyketide synthases (PKS), non ribosomal peptide synthases (NRPS) and fatty acid synthases (FAS).
Robert Bunet +9 more
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Living with an imperfect cell wall: compensation of
BMC Genomics, 2007 Background Synthesis of the Staphylococcus aureus peptidoglycan pentaglycine interpeptide bridge is catalyzed by the nonribosomal peptidyl transferases FemX, FemA and FemB.
Bierbaum Gabriele +8 more
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Microbiology Spectrum, 2022 Phosphopantetheinyl transferases (PPTases) play important roles in activating apo-acyl carrier proteins (apo-ACPs) and apo-peptidyl carrier proteins (apo-PCPs) in both primary and secondary metabolism. PPTases catalyze the posttranslational modifications
Songya Zhang +7 more
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The Ribosomal Peptidyl Transferase [PDF]
Molecular Cell, 2007 Peptide bond formation on the ribosome takes place in an active site composed of RNA. Recent progress of structural, biochemical, and computational approaches has provided a fairly detailed picture of the catalytic mechanism of the reaction. The ribosome accelerates peptide bond formation by lowering the activation entropy of the reaction due to ...
Beringer, M., Rodnina, M.
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Peptidyl transferase: ancient and exiguous [PDF]
Chemistry & Biology, 2000 The finding that the universal ribosomal peptidyl transferase is an RNA enzyme casts new light on its ancient origins, on the use of transition state analogues for ribozymes, and on the role of selection-amplification in studies of molecular evolution.
Yarus, Michael, Welch, Mark
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The Photochemical Inactivation of Peptidyl Transferase Activity [PDF]
European Journal of Biochemistry, 1975 The photochemical oxidation of the 50‐S ribosomal subunit results in a rapid irreversible loss of peptidyl transferase activity. The first‐order rate of inactivation occurring during the first forty minutes suggests that a single reactive group is being inactivated.
K K, Wan, N D, Zahid, R M, Baxter
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Hydrolysis of fMet-tRNA by Peptidyl Transferase [PDF]
Proceedings of the National Academy of Sciences, 1971 Escherichia coli and rabbit reticulocyte (f[ 3 H]Met-tRNA·AUG·ribosome) intermediates undergo hydrolysis, with release of f[ 3 H]methionine, upon addition of tRNA or CpCpA in the presence of acetone.
C T, Caskey +3 more
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Stepwise maturation of the peptidyl transferase region of human mitoribosomes [PDF]
Nature Communications, 2021 Abstract Mitochondrial ribosomes are specialized for the synthesis of membrane proteins responsible for oxidative phosphorylation. Mammalian mitoribosomes have diverged considerably from the ancestral bacterial ribosomes and feature dramatically reduced ribosomal RNAs.
Tea Lenarčič +9 more
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Peptidyl Transferase Center and the Emergence of the Translation System [PDF]
Life, 2017 In this work, the three-dimensional (3D) structure of the ancestral Peptidyl Transferase Center (PTC) built by concatamers of ancestral sequences of tRNAs was reconstructed, and its possible interactions with tRNAs molecules were analyzed. The 3D structure of the ancestral PTC was also compared with the current PTC of T. thermophilus.
Savio Torres de Farias +2 more
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The effect of gougerotin analogues on ribosomal peptidyl transferase
FEBS Letters, 1971 1. Introduction Gougerotin (I), a dipeptidyl pyrimidine nucleoside antibiotic, has been found to specifically inhibit the step of protein biosynthesis which is catalyzed by ribosomal peptidyl transferase [l-S] . Since three gougerotin analogues have been synthesized recently [6] , 1-[3(sarcosyl-D-seryl-)amino3-deoxy$-D-gluco- pyranosyl-)uracil (II, cf.
Černá, J. +2 more
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