Mechanism of release factor-mediated peptidyl-tRNA hydrolysis on the ribosome. [PDF]
ScienceTranslation termination is essential in all living organisms, ensuring that proteins have lengths strictly defined by their genes. This universal process is mediated by peptide release factors (RFs) that recognize stop codons and catalyze hydrolysis of ...
Aleksandrova EV +5 more
europepmc +2 more sources
Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs? [PDF]
, 2016 Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant microorganisms. Numerous natural nucleosides and their synthetically modified analogues have been reported to have moderate to good antibiotic activity against ...
Ferrari, Valentina +2 more
core +1 more source
Chemical probing of thiotetronate bio-assembly [PDF]
, 2017 Chemical ‘chain termination’ probes were utilised for the investigation of thiotetronate antibiotic biosynthesis in the filamentous bacteria Lentzea sp. and Streptomyces thiolactonus NRRL 15439.
Harringer, Sophia +8 more
core +1 more source
A genomic analysis and transcriptomic atlas of gene expression in Psoroptes ovis reveals feeding- and stage-specific patterns of allergen expression [PDF]
, 2019 Background: Psoroptic mange, caused by infestation with the ectoparasitic mite, Psoroptes ovis, is highly contagious, resulting in intense pruritus and represents a major welfare and economic concern for the livestock industry Worldwide.
Bartley, Kathryn +11 more
core +2 more sources
Comparative proteomic profiling reveals molecular characteristics associated with oogenesis and oocyte maturation during ovarian development of Bactrocera dorsalis (Hendel) [PDF]
, 2017 Time-dependent expression of proteins in ovary is important to understand oogenesis in insects. Here, we profiled the proteomes of developing ovaries from Bactrocera dorsalis (Hendel) to obtain information about ovarian development with particular ...
Wei, Dong +6 more
core +1 more source
The role of the phosphopantetheinyltransferase enzyme, PswP, in the biosynthesis of antimicrobial secondary metabolites by Serratia marcescens Db10 [PDF]
, 2014 Phosphopantetheinyltransferase (PPTase) enzymes fulfil essential roles in primary and secondary metabolism in prokaryotes, archaea and eukaryotes. PPTase enzymes catalyse the essential modification of the carrier protein domain of fatty acid synthases ...
Amy J. Gerc +9 more
core +4 more sources
Discovery and Biosynthesis of the Novel Glycotetrapeptide Antibiotic Biffamycin A
Angewandte Chemie, EarlyView.Genetic de‐regulation of a silent biosynthetic pathway allowed isolation and characterisation of a novel glycopeptide antibiotic named biffamycin A, which harbours unprecedented 5‐chloro‐4‐methoxy tryptophan and 3R‐hydroxy(α‐D‐mannoysl)‐D‐lysine moieties and is bioactive against MRSA and VRSA.
Michael W. Brigham +11 more
wiley +2 more sources
Filling the Gaps to Solve the Extensin Puzzle [PDF]
, 2018 Extensins (EXTs) are highly repetitive plant O-glycoproteins that require several post-translational modifications (PTMs) to become functional in plant cell walls.
Borassi, Cecilia +6 more
core +1 more source
Chemoenzymatic and Template-Directed Synthesis of Bioactive Macrocyclic Peptides [PDF]
, 2005 Nonribosomal peptide synthetases (NRPS) are large multienzyme complexes, which simultaneously represent template and biosynthetic machinery for the production of structurally diverse peptidic products that feature high pharmacological and biological ...
Grünewald, Jan +1 more
core +1 more source
Midgut proteome of an argasid tick, Ornithodoros erraticus: a comparison between unfed and engorged females [PDF]
, 2007 16 páginas, 5 figuras y 2 tablas. -- Agradecimientos: Asistencia técnica de Rocío Vizcaíno Marín y María González Sánchez, del Instituto de Recursos Naturales y Agrobiología de Salamanca (IRNASA-CSIC) y de la Dra.
Oleaga, Ana +3 more
core +1 more source