Directed evolution of the non-ribosomal peptide synthetase BpsA to enable recognition by the human Sfp-like PPTase [PDF]
, 2019 Non-ribosomal peptide synthetases (NRPSs) are large, modular enzymes that have an assembly line architecture and synthesise a diverse range of compounds such as antibiotics, siderophores and immunosuppressants.
Sissons, Jack +3 more
core +1 more source
The ribosomal peptidyl transferase
, 2017 Peptide bond formation on the ribosome takes place in an active site composed of RNA. Recent progress of structural, biochemical, and computational approaches has provided a fairly detailed picture of the catalytic mechanism of the reaction. The ribosome accelerates peptide bond formation by lowering the activation entropy of the reaction due to ...
Beringer, Malte, Rodnina, Marina
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Structural studies on enzymes of nikkomycin biosynthesis [PDF]
, 2011 Die vorliegende Arbeit beschäftigt sich hauptsächlich mit einem Teil des Biosynthesewegs von Nikkomycinen. Nikkomycine sind Peptid-Nukleosid-Verbindungen, die dem physiologischen Substrat der Chitinsynthase ähneln und aus diesem Grund die Fähigkeit ...
Oberdorfer, Gustav
core
Proteomic analysis of the heat shock and acclimation responses of Cyanobacteria [PDF]
, 2005 The cyanobacterium Synechocystis sp. PCC 6803 is a model experimental organism for proteomic research because its entire genomic sequence is available and cyanobacteria have high adaptive potential towards a variety of environmental stresses.
Hall, John James
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Rôle de la 4'-phosphopantethéïnyl transférase PptT dans la multiplication et la persistance de Mycobacterium tuberculosis et mise en place d'un test d'activité enzymatique pour la recherche de nouveaux antituberculeux [PDF]
, 2012 Mycobacterium tuberculosis (Mtb), l'agent de la tuberculose humaine, possède une enveloppe cellulaire atypique contenant une grande variété de lipides spécifiques, certains d'entre eux étant essentiels pour la viabilité du bacille tuberculeux ou ...
Leblanc, Cécile
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Molecular characterization of the Arabidopsis thaliana - Botrytis cinerea interaction [PDF]
, 2008 Includes bibliographical references (leaves 199-253).This study attempted to characterize at a transcriptional level, the defence responses of Arabidopsis thaliana after infection by Botrytis cinerea, using microarrays.
Mulema, Joseph Mary K
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Synthesis of Peptidyl-tRNA Mimics for Structural Biology Applications. [PDF]
Acc Chem Res, 2023 Polikanov YS +2 more
europepmc +1 more source
The Peptidyl Transferase Activity of Ribosomes
Cold Spring Harbor Symposia on Quantitative Biology, 1969 R E, Monro +3 more
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Characterisation of pneumococcal peptidoglycan cross-linking enzymology [PDF]
Despite the introduction of penicillin, infections caused by Streptococcus pneumoniae are associated with significant morbidity and mortality. As a result, there is an urgent need for successful identification of new drug targets within the organism ...
Shepherd, Jennifer
core
Peptidyl‐tRNA and peptidyl transferase activity of skeletal muscle ribosomes. Effect of diabetes [PDF]
FEBS Letters, 1970 Stirewalt, William S., Wool, Ira G.
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