Results 31 to 40 of about 3,853 (141)
Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions
MedComm, Volume 7, Issue 7, July 2026.Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An +4 more
wiley +1 more source
Effect of cytidine‐5′‐monophosphate on peptidyl transferase activity [PDF]
FEBS Letters, 1975 The transfer reaction with pA-fMet as a donor substrate is strongly stimulated by CMP, whereas the transfer reaction with CpApCpCpA-acLeu as a donor substrate is inhibited by CMP. These results indicate that the donor site of peptidyl transferase contains specific binding sites for the terminal adenosine and for the cytidylic acid residue in the ...
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SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies
PROTEOMICS, Volume 26, Issue 7, Page 69-83, July 2026.ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà +10 more
wiley +1 more source
The ribosome as a versatile catalyst: reactions at the peptidyl transferase center [PDF]
Current Opinion in Structural Biology, 2013 In all contemporary organisms, the active site of the ribosome--the peptidyl transferase center--catalyzes two distinct reactions, peptide bond formation between peptidyl-tRNA and aminoacyl-tRNA as well as the hydrolysis of peptidyl-tRNA with the help of a release factor. However, when provided with appropriate substrates, ribosomes can also catalyze a
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PROTEOMICS – Clinical Applications, Volume 20, Issue 4, July 2026.ABSTRACT Background and aims Non‐alcoholic Fatty Liver Disease (NAFLD) affects about a quarter of the world's population. Liver biopsy remains the gold standard for diagnosing the progressive form of NAFLD called Non‐alcoholic Steatohepatitis (NASH) but it is invasive, prone to sampling errors and observer variability, and impractical for widespread ...
Anna Negroni +5 more
wiley +1 more source
Environmental Microbiology, Volume 28, Issue 7, July 2026.Genomic, proteomic and phylogenetic analyses of the obligate yeast‐like symbiont (YLS) associated with Scaphoideus titanus revealed retained metabolic flexibility and a monophyletic origin of insect‐associated YLSs within a free‐living fungal lineage. A novel computational pipeline was used to mine NCBI transcriptomic data and identified new candidate ...
Simona Abbà +6 more
wiley +1 more source
The ribosomal peptidyl transferase
, 2017 Peptide bond formation on the ribosome takes place in an active site composed of RNA. Recent progress of structural, biochemical, and computational approaches has provided a fairly detailed picture of the catalytic mechanism of the reaction. The ribosome accelerates peptide bond formation by lowering the activation entropy of the reaction due to ...
Beringer, Malte, Rodnina, Marina
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Synthesis of Peptidyl-tRNA Mimics for Structural Biology Applications. [PDF]
Acc Chem Res, 2023 Polikanov YS +2 more
europepmc +1 more source
The Peptidyl Transferase Activity of Ribosomes
Cold Spring Harbor Symposia on Quantitative Biology, 1969 R E, Monro +3 more
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Peptidyl‐tRNA and peptidyl transferase activity of skeletal muscle ribosomes. Effect of diabetes [PDF]
FEBS Letters, 1970 Stirewalt, William S., Wool, Ira G.
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