Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest [PDF]
Nucleic Acids Research, 2018 Several ATPases in the ATP-binding cassette F (ABCF) family confer resistance to macrolides, lincosamides and streptogramins (MLS) antibiotics. MLS are structurally distinct classes, but inhibit a common target: the peptidyl transferase (PTC) active site
Victoriia Murina +3 more
openalex +2 more sources
Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in "Saccharomyces cerevisiae" [PDF]
, 2013 The 25S rRNA of yeast contains several base modifications in the functionally important regions. The enzymes responsible for most of these base modifications remained unknown.
Entian, Karl-Dieter +3 more
core +1 more source
Age-related thermal response: the cellular resilience of juveniles [PDF]
, 2015 Understanding species’ responses to environmental challenges is key to predicting future biodiversity. However, there is currently little data on how developmental stages affect responses and also whether universal gene biomarkers to environmental stress
Burns, G. +3 more
core +1 more source
Peptidyl Transferase Center and the Emergence of the Translation System [PDF]
Life, 2017 In this work, the three-dimensional (3D) structure of the ancestral Peptidyl Transferase Center (PTC) built by concatamers of ancestral sequences of tRNAs was reconstructed, and its possible interactions with tRNAs molecules were analyzed. The 3D structure of the ancestral PTC was also compared with the current PTC of T. thermophilus.
Savio Torres de Farias +2 more
openaire +2 more sources
4′-Phosphopantetheine Transfer in Primary and Secondary Metabolism of Bacillus subtilis *
Journal of Biological Chemistry, 2001 4′-Phosphopantetheine transferases (PPTases) transfer the 4′-phosphopantetheine moiety of coenzyme A onto a conserved serine residue of acyl carrier proteins (ACPs) of fatty acid and polyketide synthases as well as peptidyl carrier proteins (PCPs) of ...
H. Mootz, Robert Finking, M. Marahiel
semanticscholar +1 more source
Resistance to ketolide antibiotics by coordinated expression of rRNA methyltransferases in a bacterial producer of natural ketolides [PDF]
, 2015 Significance Studies of antibiotic resistance are usually initiated in earnest only after resistance has become established in clinical pathogens.
Almutairi, Mashal M +7 more
core +2 more sources
Nature Structural & Molecular Biology, 2022 Ribosome-targeting antibiotics serve as powerful antimicrobials and as tools for studying the ribosome, the catalytic peptidyl transferase center (PTC) of which is targeted by many drugs.
E. A. Syroegin +5 more
semanticscholar +1 more source
4-Phosphopantethein Transfer in Bacillus subtilis und Pseudomonas aeruginosa sowie Grundlagen zur gerichteten Proteinevolution von Adenylierungsdomänen der Nichtribosomalen Peptidsynthetasen [PDF]
, 2003 Carrier Proteine (CP) werden in unterschiedlichen prokaryontischen und eukaryontischen Synthesesystemen als Transporteinheiten für die Syntheseintermediate eingesetzt.
Finking, Robert +1 more
core +1 more source
Protein expression profiles in Bathymodiolus azoricus exposed to cadmium.
Ecotoxicology and Environmental Safety, 2019 Proteomic changes in the "gill-bacteria complex" of the hydrothermal vent mussel B. azoricus exposed to cadmium in pressurized chambers ((Incubateurs Pressurises pour l'Observation en Culture d'Animaux Marins Profonds - IPOCAMP) were analyzed and ...
R. Company +7 more
semanticscholar +1 more source
Synthetic and Systems Biotechnology, 2022 Non-ribosomal peptide synthetases (NRPSs) are attractive targets for biosynthetic pathway engineering due to their modular architecture and the therapeutic relevance of their products.
Joshua C. Corpuz +2 more
semanticscholar +1 more source