Living with an imperfect cell wall: compensation of
BMC Genomics, 2007 Background Synthesis of the Staphylococcus aureus peptidoglycan pentaglycine interpeptide bridge is catalyzed by the nonribosomal peptidyl transferases FemX, FemA and FemB.
Bierbaum Gabriele +8 more
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Stepwise maturation of the peptidyl transferase region of human mitoribosomes [PDF]
Nature Communications, 2021 Abstract Mitochondrial ribosomes are specialized for the synthesis of membrane proteins responsible for oxidative phosphorylation. Mammalian mitoribosomes have diverged considerably from the ancestral bacterial ribosomes and feature dramatically reduced ribosomal RNAs.
Tea Lenarčič +9 more
openaire +6 more sources
FemABX peptidyl transferases: a link between branched-chain cell wall peptide formation and beta-lactam resistance in gram-positive cocci. [PDF]
Antimicrob Agents Chemother, 2003 Rohrer S, Berger-Bächi B.
europepmc +2 more sources
Peptide Bond Formation between Aminoacyl-Minihelices by a Scaffold Derived from the Peptidyl Transferase Center [PDF]
Life, 2022 The peptidyl transferase center (PTC) in the ribosome is composed of two symmetrically arranged tRNA-like units that contribute to peptide bond formation.
M. Kawabata +5 more
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Cryo-EM studies of the four E. coli paralogs establish ABCF proteins as master plumbers of the peptidyl-transferase center of the ribosome [PDF]
bioRxiv, 2023 Shikha Singh +15 more
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The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis [PDF]
Nature CommunicationsDEAD-box ATPases play crucial roles in guiding rRNA restructuring events during the biogenesis of large (60S) ribosomal subunits, but their precise molecular functions are currently unknown.
Victor E. Cruz +3 more
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Loss of Conserved rRNA Modifications in the Peptidyl Transferase Center Leads to Diminished Protein Synthesis and Cell Growth in Budding Yeast. [PDF]
Int J Mol SciLeppik M +5 more
europepmc +3 more sources
Bacterial riboproteogenomics : the era of N-terminal proteoform existence revealed [PDF]
, 2020 With the rapid increase in the number of sequenced prokaryotic genomes, relying on automated gene annotation became a necessity. Multiple lines of evidence, however, suggest that current bacterial genome annotations may contain inconsistencies and are ...
Fijalkowska, Daria +3 more
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Translational impacts of enzymes that modify ribosomal RNA around the peptidyl transferase centre. [PDF]
RNA BiolBao L +5 more
europepmc +3 more sources
Inhibition of phospho-MurNAc-pentapeptide translocase (MraY) by nucleoside natural product antibiotics, bacteriophage
, 2016 This review covers recent developments in the inhibition of translocase MraY and related phospho-GlcNAc transferases WecA and TagO, and insight into the inhibition and catalytic mechanism of this class of integral membrane proteins from the structure of ...
Bugg, Tim +3 more
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