Results 11 to 20 of about 3,838 (150)

Synthesis of RNA conjugates as bisubstrates for the study of transferases [PDF]

Comptes Rendus. Chimie
Bisubstrate compounds are designed to mimic the interaction of enzymes with their two natural substrates. These molecules contain two moieties mimicking the two substrates linked together by a covalent bridge, which enhances both selectivity and potency.
Iannazzo, Laura, Braud, Emmanuelle, Fonvielle, Matthieu,  Etheve-Quelquejeu, Mélanie   +3 more
doaj   +3 more sources

FemABX peptidyl transferases: a link between branched-chain cell wall peptide formation and beta-lactam resistance in gram-positive cocci. [PDF]

Antimicrob Agents Chemother, 2003
Rohrer S, Berger-Bächi B.
europepmc   +3 more sources

Programmed Delivery of Novel Functional Groups to the Alpha Class Glutathione Transferases^† [PDF]

, 2016
Here we describe a new route to site- and class-specific protein modification that will allow us to create novel functional proteins with artificial chemical groups.
Sofia Håkansson (2947917), Kerstin S. Broo (1277667), Johan Viljanen (2002006)   +2 more
core   +1 more source

Programmed Delivery of Novel Functional Groups to the Alpha Class Glutathione Transferases [PDF]

, 2003
Here we describe a new route to site- and class-specific protein modification that will allow us to create novel functional proteins with artificial chemical groups.
Viljanen, Johan,, Håkansson Hederos, Sofia,, Broo, Kerstin,   +2 more
core   +1 more source

Electrophilic RNA for Peptidyl-RNA Synthesis and Site-Specific Cross-Linking with tRNA-Binding Enzymes. [PDF]

, 2016
International audienceRNA functionalization is challenging due to the instability of RNA and the limited range of available enzymatic reactions.
Matthieu Fonvielle, Michel Arthur, Chloé Le Fournis, Cardon, S, Mengin-Lecreulx, Dominique, Sakkas, N, Dominique Mengin‐Lecreulx, Mengin-Lecreulx, D, Cardon, Sébastien, Le Fournis, C, Fonvielle, M, Braud, Emmanuelle, Mélanie Etheve‐Quelquejeu, Arthur, M, El-Sagheer, A, Afaf El‐Sagheer, Emmanuelle Braud, Brown, Tom, Braud, E, Delphine Patin, Patin, Delphine, El-Sagheer, Afaf, Patin, D, Arthur, Michel, Etheve-Quelquejeu, Mélanie, Sébastien Cardon, Brown, T, Iannazzo, Laura, Nicolas Sakkas, Tom Brown, Etheve-Quelquejeu, M, Le Fournis, Chloé, Sakkas, Nicolas, Iannazzo, L, Fonvielle, Matthieu, Laura Iannazzo   +35 more
core   +2 more sources

The insect pathogen Serratia marcescens Db10 uses a hybrid non-ribosomal peptide synthetase-polyketide synthase to produce the antibiotic althiomycin [PDF]

, 2012
There is a continuing need to discover new bioactive natural products, such as antibiotics, in genetically-amenable micro-organisms. We observed that the enteric insect pathogen, Serratia marcescens Db10, produced a diffusible compound that inhibited the
Coulthurst Sarah J., Challis Gregory L., Stanley-Wall, Nicola R; id_orcid, Gregory L Challis, Gerc, Amy J., Amy J. Gerc, Gerc Amy J., Nicola R Stanley-Wall, Gregory L. Challis (136140), Song Lijiang, Coulthurst, Sarah J; id_orcid, Sarah J. Coulthurst, Lijiang Song (136135), Lijiang Song, Stanley-Wall, Nicola R., Stanley-Wall Nicola R., Coulthurst, Sarah J., Nicola R. Stanley-wall, Challis, Gregory L., Challis, Gregory L, Amy J Gerc, Sarah J. Coulthurst (136148), Song, Lijiang, Gerc, Amy J, Amy J. Gerc, Amy J. Gerc (136131), Nicola R. Stanley-Wall (136144), Sarah J Coulthurst, Gregory L. Challis   +28 more
core   +1 more source

The role of the phosphopantetheinyltransferase enzyme, PswP, in the biosynthesis of antimicrobial secondary metabolites by Serratia marcescens Db10 [PDF]

, 2014
Phosphopantetheinyl transferase (PPTase) enzymes fulfil essential roles in primary and secondary metabolism in prokaryotes, archaea and eukaryotes. PPTase enzymes catalyse the essential modification of the carrier protein domain of fatty acid synthases ...
Gerc, Amy J., Stanley-Wall, Nicola R.; id_orcid, Coulthurst, Sarah J.; id_orcid   +2 more
core   +1 more source

Protein expression profiles in Bathymodiolus azoricus exposed to cadmium [PDF]

, 2019
Proteomic changes in the "gill-bacteria complex" of the hydrothermal vent mussel B. azoricus exposed to cadmium in pressurized chambers ((Incubateurs Pressurises pour l'Observation en Culture d'Animaux Marins Profonds - IPOCAMP) were analyzed and ...
Shillito, Bruce, Bebianno, Maria João, Antúnez, Oreto, Bebianno, Maria, Company, Rui, Cosson, Richard P., Cajaraville, Miren, Torreblanca, Amparo, Cosson, Richard, Serafim, M. A., Serafim, Angela   +10 more
core   +3 more sources

Efficient Preparation of Site-Specific Antibody–Drug Conjugates Using Phosphopantetheinyl Transferases [PDF]

, 2015
Post-translational modification catalyzed by phosphopantetheinyl transferases (PPTases) has previously been used to site-specifically label proteins with structurally diverse molecules.
Ou, Weijia, Paula Patterson (1459741), Patterson, Paula, Cellitti, Susan, Zhou, Huanfang, Dylan Daniel (1459738), Chiu, Hsien-Po, Grunewald, Jan, Tong, Hung, Weijia Ou (1459714), Bernhard H. Geierstanger (1459717), Badry Bursulaya (1273446), Bursulaya, Badry, William Mallet (1459753), Daniel, Dylan, Brock, Ansgar, Julie Vance (1459726), Nigoghossian, Edward, Mallet, William, Susan E. Cellitti (1459720), Hung Tong (1459756), Jan Grünewald (1459729), Heath E. Klock (1459732), Huanfang Zhou (1459744), Klock, Heath, Hsien-Po Chiu (1459708), Lesley, Scott, Tetsuo Uno (1459750), Edward Nigoghossian (1459735), Vance, Julie, David H. Jones (1459711), Scott A. Lesley (147512), Uno, Tetsuo, Ansgar Brock (1459747), Geierstanger, Bernhard, Xing Wang (154377), Jones, David, Daniel McMullan (1459723), Mcmullan, Daniel   +38 more
core   +1 more source

Identification and characterization of a type II peptidyl carrier protein from the bleomycin producer Streptomyces verticillus ATCC 15003 [PDF]

, 1999
BackgroundNonribosomal peptide synthetases (NRPSs) catalyze the assembly of a structurally diverse group of peptides by the multiple-carrier thiotemplate mechanism.
Liangcheng Du, Ben Shen, Shen, Ben, Du, Liangcheng   +3 more
core   +1 more source