Boronate-Based Inhibitors of Penicillin-Binding Proteins: An Underestimated Avenue for Antibiotic Discovery? [PDF]
PharmaceuticalsPenicillin-binding proteins (PBPs) are essential enzymes involved in bacterial cell wall biosynthesis and represent the primary targets of β-lactam antibiotics.
Valentina Villamil +4 more
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Penicillin-binding proteins exhibit functional redundancy during asymmetric cell division in Clostridioides difficile [PDF]
Journal of BacteriologyPeptidoglycan synthesis is an essential driver of bacterial growth and division. The final steps of this crucial process involve the polymerization of glycan strands by shape, elongation, division, and sporulation (SEDS) family glycosyltransferases and ...
Shailab Shrestha +4 more
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Antibiotics, 2016 Peptidoglycan (PG) is an essential macromolecular sacculus surrounding most bacteria. It is assembled by the glycosyltransferase (GT) and transpeptidase (TP) activities of multimodular penicillin-binding proteins (PBPs) within multiprotein complex ...
Eric Sauvage, Mohammed Terrak
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Morphogenetic penicillin-binding proteins control virulence-associated type III secretion systems in Salmonella [PDF]
Infection and ImmunityType III protein secretion systems (T3SSs) function as multiprotein devices that span the envelope of Gram-negative bacteria using the peptidoglycan (PG) layer as scaffold.
Sónia Castanheira +3 more
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Dynamical Behavior of β-Lactamases and Penicillin- Binding Proteins in Different Functional States and Its Potential Role in Evolution [PDF]
Entropy, 2019 β-Lactamases are enzymes produced by bacteria to hydrolyze β-lactam-based antibiotics, and pose serious threat to public health through related antibiotic resistance.
Feng Wang +3 more
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Weaknesses out of strength: PNA against the penicillin-binding proteins [PDF]
Molecular Therapy: Nucleic AcidsMateusz Wdowiak
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The penicillin-binding proteins of Bacilli
, 2019 A study of the penicillin-binding proteins (PBPs) in the membranes of various species of Bacilli by dodecylsulphate/polyacrylamide gel electrophoresis followed by detection of the PBPs by fluorography has shown the presence of 3-5 such proteins depending on the species.
openaire +3 more sources
Comparison of Bioorthogonal β‐Lactone Activity‐Based Probes for Selective Labeling of Penicillin‐Binding Proteins [PDF]
ChemBioChem, 2021 Nathaniel W Brown +2 more
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Frontiers in Microbiology, 2023 IntroductionFor Streptococcus pneumoniae, β-lactam susceptibility can be predicted from the amino acid sequence of the penicillin-binding proteins PBP1a, PBP2b, and PBP2x.
Helle Brander Eriksen +13 more
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New noncovalent inhibitors of penicillin-binding proteins from penicillin-resistant bacteria. [PDF]
PLoS ONE, 2011 BACKGROUND: Penicillin-binding proteins (PBPs) are well known and validated targets for antibacterial therapy. The most important clinically used inhibitors of PBPs β-lactams inhibit transpeptidase activity of PBPs by forming a covalent penicilloyl ...
Samo Turk +10 more
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