Potential role of avibactam in restoring susceptibility in Escherichia coli with two copies of blaKPC-3 and PBP3 mutations [PDF]
Scientific ReportsThe emergence of carbapenemase-producing Enterobacterales represents a significant clinical challenge. Resistance mechanisms involve carbapenemase production, porin and efflux pump alterations, penicillin-binding protein (PBP) modifications, and biofilm ...
Valeria Fox +2 more
exaly +5 more sources
Crystal Structure of Penicillin-Binding Protein 3 (PBP3) from Escherichia coli [PDF]
PLoS ONE, 2014 In Escherichia coli, penicillin-binding protein 3 (PBP3), also known as FtsI, is a central component of the divisome, catalyzing cross-linking of the cell wall peptidoglycan during cell division. PBP3 is mainly periplasmic, with a 23 residues cytoplasmic
Eric Sauvage +2 more
exaly +7 more sources
Communications BiologyPenicillin binding proteins (PBPs) are well validated antimicrobial targets, but the prevalence of β-lactamase driven resistance and, more rarely, target-based mutations, necessitates new classes of PBP-targeting drugs. Here we describe the discovery and
Catherine E Rowland +2 more
exaly +4 more sources
Emergence of Klebsiella pneumoniae Carbapenemase–Producing K. pneumoniae with Penicillin-Binding Protein 3 Insertions, Taiwan, 2021 [PDF]
Emerging Infectious DiseasesCarbapenem-resistant Enterobacterales (CRE) are a major global health threat with limited treatment options. Aztreonam/avibactam is a promising therapy against metallo-β-lactamase (MBL)–producing and other CRE, but emerging resistance threatens its ...
Tengfei Long +6 more
doaj +2 more sources
Discovery of Pyrrolidine-2,3-diones as Novel Inhibitors of P. aeruginosa PBP3
Antibiotics, 2021 The alarming threat of the spread of multidrug resistant bacteria currently leaves clinicians with very limited options to combat infections, especially those from Gram-negative bacteria.
Arancha López-Pérez +9 more
doaj +8 more sources
A FtsZ inhibitor-acinetobactin conjugate with enhanced cellular uptake in Acinetobacter baumannii acts synergistically in combination with PBP3-targeting antibiotics. [PDF]
PLoS ONEMultidrug resistance in the Gram-negative bacterial pathogen Acinetobacter baumannii is a global public health threat, highlighting a critical need for drug development.
Eric J Bryan +6 more
doaj +4 more sources
A novel PBP3 substitution in Haemophilus influenzae confers reduced aminopenicillin susceptibility [PDF]
BMC Microbiology, 2018 Background Identification and characterization of non-typeable Haemophilus influenzae (NTHi) with reduced susceptibility to β-lactam antibiotics due to mutations in penicillin binding protein 3 (PBP3) is a clinical challenge. We analyzed a blood isolate,
John Thegerström +4 more
doaj +3 more sources
Stationary phase persister formation in Escherichia coli can be suppressed by piperacillin and PBP3 inhibition [PDF]
BMC Microbiology, 2019 Background Persisters are rare phenotypic variants within a bacterial population that are capable of tolerating lethal antibiotic concentrations. Passage through stationary phase is associated with the formation of persisters (type I), and a major ...
Sandra J. Aedo +2 more
doaj +3 more sources
Penicillin-binding proteins exhibit functional redundancy during asymmetric cell division in Clostridioides difficile [PDF]
Journal of BacteriologyPeptidoglycan synthesis is an essential driver of bacterial growth and division. The final steps of this crucial process involve the polymerization of glycan strands by shape, elongation, division, and sporulation (SEDS) family glycosyltransferases and ...
Shailab Shrestha +4 more
doaj +2 more sources
Molecular dissection of Class A PBP function uncovers novel features of the non-canonical Clostridioides difficile divisome complex. [PDF]
PLoS GeneticsCell division in bacteria is mediated by the "divisome," a multiprotein complex that synthesizes the septal peptidoglycan needed to divide one cell into two.
Gregory A Harrison, Aimee Shen
doaj +2 more sources