Incidence of Cefotaxime‐Resistant Haemophilus influenzae Is Linked to Regional Consumption of Oral Aminopenicillins and Parenteral Third‐Generation Cephalosporins in Norway [PDF]
APMIS, Volume 134, Issue 4, April 2026.ABSTRACT The emergence of cefotaxime‐resistant Haemophilus influenzae (CRHI) in Norway during the 2000s coincided with increased use of oral aminopenicillins and parenteral third‐generation cephalosporins. This study examined associations between beta‐lactam consumption and CRHI incidence. Surveillance data on antibiotic usage across Norwegian regions (
Dagfinn Skaare, Gunnar Skov Simonsen
wiley +2 more sources
Computational Perspectives on Amoxicillin and Staphylococcus Aureus in Mirror Life [PDF]
Global Challenges, Volume 9, Issue 8, August 2025.Mirror life is a possible incoming threat. PBP3 of S. aureus, a well‐known target of amoxicillin and other β‐lactam antibiotics, is investigated along with its mirror image showing that the enantiomeric target may elude currently available biocides. Computational tools are safe and reliable to investigate mirror‐life related aspects, either supporting ...
Lorenzo Pedroni +3 more
wiley +2 more sources
Effect of sigma factor S (sigmaS) on the stability of penicillin-binding protein 3 (PBP3) of Escherichia colt K12 [PDF]
Brazilian Journal of Genetics, 1996 The stability of penicillin-binding protein 3 (PBP3), a cell septum synthesizing protein, was analyzed at different incubation temperatures in three Escherichia coli K12 strains carrying a PBP3-overproducing plasmid. The stability of PBP3 was significantly reduced in stationary phase cells shifted to 42°C for 4 h, compared to samples incubated at 28 or
Rosane S. Machado +3 more
openalex +5 more sources
PLoS ONE, 2014 Penicillin-binding proteins (PBPs) are enzymes responsible for the polymerization of the glycan strand and the cross-linking between glycan chains as well as the target proteins for β-lactam antibiotics. Mutational alterations in PBPs can confer resistance either by reducing binding of the antibiotic to the active site or by evolving a β-lactamase ...
Song Sun, M. Selmer, Dan I. Andersson
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Identifying Novel Therapeutics for the Resistant Mutant “F533L” in PBP3 of Pseudomonas aeruginosa Using ML Techniques [PDF]
ACS OmegaPseudomonas aeruginosa (P. aeruginosa) is a highly infectious and antibiotic-resistant bacterium, which causes acute and chronic nosocomial infections. P. aeruginosa exhibits multidrug resistance due to the emergence of resistant mutants. The bacterium takes advantage of intrinsic and acquired resistance mechanisms to resist almost every antibiotic. To
Tushar Joshi +5 more
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Penicillin-binding proteins exhibit functional redundancy during asymmetric cell division in Clostridioides difficile [PDF]
Journal of BacteriologyPeptidoglycan synthesis is an essential driver of bacterial growth and division. The final steps of this crucial process involve the polymerization of glycan strands by shape, elongation, division, and sporulation (SEDS) family glycosyltransferases and ...
Shailab Shrestha +4 more
doaj +2 more sources
Amino acid substitutions in PBP3 in Haemophilus influenzae strains, their phenotypic detection and impact on resistance to β-lactams [PDF]
Journal of Antimicrobial ChemotherapyAbstract Background Data from surveillance on antibiotic resistance have shown an increasing prevalence of non-enzymatic resistance (β-lactamase-negative ampicillin-resistant) to β-lactam antibiotics among H. influenzae strains in the Czech Republic.
Vladislav Jakubů +5 more
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Molecular dissection of Class A PBP function uncovers novel features of the non-canonical Clostridioides difficile divisome complex. [PDF]
PLoS GeneticsCell division in bacteria is mediated by the "divisome," a multiprotein complex that synthesizes the septal peptidoglycan needed to divide one cell into two.
Gregory A Harrison, Aimee Shen
doaj +2 more sources
Interaction between membrane proteins PBP3 and rodA is required for normal cell shape and division in Escherichia coli [PDF]
Journal of Bacteriology, 1986 In Escherichia coli, the products of several genes are required for septation, and the products of several others are required for the maintenance of the rod shape of the cells. We show here that the combination of certain mutations in a division gene (ftsI) with a specific mutation in one of the shape genes (rodA) could produce cells with normal shape
K J Begg, Brian G. Spratt, W. Donachie
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Whole-genome analysis of NDM-producing Providencia hangzhouensis associated with recurrent bacteraemia with rapid development of aztreonam-avibactam resistance [PDF]
Emerging Microbes and InfectionsA 60-year-old male with recurrent bacteremia associated with necrotizing pancreatitis was followed over 17 months, during which six clinical isolates of Providencia were obtained. The index isolate (R1) was susceptible to aztreonam-avibactam (MIC 4 mg/L),
Ka Lip Chew +6 more
doaj +2 more sources