Results 21 to 30 of about 2,944 (157)

Interaction of FtsA and PBP3 proteins in the Escherichia coli septum [PDF]

Journal of Bacteriology, 1986
Mutations in the ftsA gene of Escherichia coli conferred a higher resistance to lysis induced by penicillin or by a combination of cefsulodin and furazlocillin. The ftsA2 allele codes for an FtsA protein which is inactive at 42 degrees C but is able to regain its activity once it is transferred back to 30 degrees C; ftsA2 filaments formed at 42 degrees
A, Tormo, J A, Ayala, M A, de Pedro, M, Aldea, M, Vicente   +4 more
openaire   +2 more sources

PBP3 inhibition elicits adaptive responses in Pseudomonas aeruginosa [PDF]

Molecular Microbiology, 2006
SummaryAdaptive evolution depends on both the genetic variability in a population of organisms and the selection of the better adapted genotypes. However, for the fittest variants to be selected they must survive over a sufficient period under the new conditions.
Jesús, Blázquez, José-María, Gómez-Gómez, Antonio, Oliver, Carlos, Juan, Vivek, Kapur, Soledad, Martín   +5 more
openaire   +2 more sources

Molecular Cytology of ‘Little Animals’: Personal Recollections of Escherichia coli (and Bacillus subtilis)

Life, 2023
This article relates personal recollections and starts with the origin of electron microscopy in the sixties of the previous century at the University of Amsterdam.
Nanne Nanninga
doaj   +1 more source

Incidence of Cefotaxime-Resistant Haemophilus influenzae Is Linked to Regional Consumption of Oral Aminopenicillins and Parenteral Third-Generation Cephalosporins in Norway. [PDF]

APMIS
ABSTRACT The emergence of cefotaxime‐resistant Haemophilus influenzae (CRHI) in Norway during the 2000s coincided with increased use of oral aminopenicillins and parenteral third‐generation cephalosporins. This study examined associations between beta‐lactam consumption and CRHI incidence. Surveillance data on antibiotic usage across Norwegian regions (
Skaare D, Simonsen GS.
europepmc   +2 more sources

Hybrid proteins of the transglycosylase and the transpeptidase domains of PBP1B and PBP3 of Escherichia coli [PDF]

Journal of Bacteriology, 1995
The construction of hybrid proteins of PBP1B and PBP3 has been described. One hybrid protein (PBP1B/3) contained the transglycosylase domain of PBP1B and the transpeptidase domain of PBP3. In the other hybrid protein, the putative transglycosylase domain of PBP3 was coupled to the transpeptidase domain of PBP1B (PBP3/1B).
Zijderveld, C.A.L., Waisfisz, Q., Aarsman, M.E.G., Nanninga, N.   +3 more
openaire   +4 more sources

Computational Perspectives on Amoxicillin and Staphylococcus Aureus in Mirror Life. [PDF]

Glob Chall
Mirror life is a possible incoming threat. PBP3 of S. aureus, a well‐known target of amoxicillin and other β‐lactam antibiotics, is investigated along with its mirror image showing that the enantiomeric target may elude currently available biocides. Computational tools are safe and reliable to investigate mirror‐life related aspects, either supporting ...
Pedroni L, Dall'Asta C, Galaverna G, Dellafiora L.   +3 more
europepmc   +2 more sources

A Review of <i>β</i>-Lactamase Inhibitors in Clinical Use and Development: Mechanisms, Spectrum, and Therapeutic Applications. [PDF]

Int J Microbiol
β‐Lactam antibiotics have long served as a cornerstone for treating bacterial infections. However, their widespread and often indiscriminate use has fueled the emergence of multidrug‐resistant Gram‐negative pathogens, primarily through the production and dissemination of β‐lactamase enzymes.
Gourabi MJR, Nikoo A, Khanbabaei B, Kargar M, Fayyazi A, Mousavi SMJ, Aghdaee A, Hashemi A, Sharahi JY.   +8 more
europepmc   +2 more sources

Resistance to aztreonam-avibactam due to CTX-M-15 in the presence of penicillin-binding protein 3 with extra amino acids in Escherichia coli

Frontiers in Microbiology, 2022
Aztreonam-avibactam is a promising combination to treat carbapenem-resistant Enterobacterales including coverage for metallo-β-lactamases. Escherichia coli strains resistant to aztreonam-avibactam have emerged but resistance mechanisms remain to be ...
Ke Ma, Zhiyong Zong, Zhiyong Zong, Zhiyong Zong   +3 more
doaj   +1 more source

Case Commentary: When one target is not enough-PBP3 insertions and target redundancy in <i>Escherichia coli</i>. [PDF]

Antimicrob Agents Chemother
ABSTRACT This challenging clinical case highlights the impact of PBP3 insertions in Escherichia coli , which reduce susceptibility to key β-lactam agents and complicate treatment, particularly in the setting of NDM production ...
Stellfox ME, Doi Y.
europepmc   +2 more sources

Interaction between two murein (peptidoglycan) synthases, PBP3 and PBP1B, in Escherichia coli [PDF]

Molecular Microbiology, 2006
SummaryThe murein (peptidoglycan) sacculus is an essential polymer embedded in the bacterial envelope. The Escherichia coli class B penicillin‐binding protein (PBP) 3 is a murein transpeptidase and essential for cell division. In an affinity chromatography experiment, the bifunctional transglycosylase‐transpeptidase murein synthase PBP1B was retained ...
Bertsche, U., Kast, T., Wolf, B., Fraipont, C., Aarsman, M.E.G., Kannenberg, K., von Rechenberg, M., Nguyen-Distèche, M., den Blaauwen, T., Höltje, J-V., Vollmer, W.   +10 more
openaire   +7 more sources