Results 11 to 20 of about 2,944 (157)

Evolution of mutations in the ftsI gene leading to amino acid substitutions in PBP3 in Haemophilus influenzae strains under the selective pressure of ampicillin and cefuroxime

International Journal of Medical Microbiology
Background: Aminopenicillins are recommended agents for non-invasive Haemophilus influenzae infections. One of the mechanisms of resistance to β-lactams is the alteration of the transpeptidase region of penicillin binding protein 3 (PBP3) which is caused
Vladislav Jakubů, Ibrahim Bitar, Lucia Malisova   +2 more
exaly   +3 more sources

Repurposing the angiotensin II receptor blocker valsartan to inhibit penicillin-binding protein 3 and its mutants in Haemophilus influenzae: a comprehensive in silico approach [PDF]

Frontiers in Bioinformatics
IntroductionAmpicillin-resistant Haemophilus influenzae (H. influenzae) has been recently designated as a medium-priority bacterial pathogen in 2024 by the World Health Organization (WHO).
Srujal Kacha, Srujal Kacha, Janani Arun, Neelu Nargund, Tushar Joshi, Shalini Mathpal, Sudha Ramaiah, Sudha Ramaiah, Anand Anbarasu, Anand Anbarasu   +9 more
doaj   +2 more sources

Whole-genome analysis of NDM-producing Providencia hangzhouensis associated with recurrent bacteraemia with rapid development of aztreonam-avibactam resistance [PDF]

Emerging Microbes and Infections
A 60-year-old male with recurrent bacteremia associated with necrotizing pancreatitis was followed over 17 months, during which six clinical isolates of Providencia were obtained. The index isolate (R1) was susceptible to aztreonam-avibactam (MIC 4 mg/L),
Ka Lip Chew, Yuan Qiao, Priscillia Lye, Joey Cruz Cabang, Nur Aisyah Binte Abu Bakar, Ker Xin Tan, Jeanette Teo   +6 more
doaj   +2 more sources

High in vitro activity of aztreonam/avibactam against NDM-producing Enterobacterales with emerging resistance in Escherichia coli in the United States Mid-Atlantic region [PDF]

Microbiology Spectrum
New Delhi metallo-β-lactamase (NDM)-producing Enterobacterales represent a critical antimicrobial resistance threat with limited therapeutic options. Aztreonam/avibactam, which combines the stability of aztreonam against metallo-β-lactamases with the ...
Eetu Eklund, Tyler Maruca, Kate Kruczynski, Heather Critchfield, Robert Murphy, Eric Keller, Benjamin Lee, Ami Patel, Liore Klein, David A. Torpey, Robert A. Myers, Victoria L. Campodónico   +11 more
doaj   +2 more sources

Specific variants in ftsI reduce carbapenem susceptibility in Pseudomonas aeruginosa [PDF]

Microbiology Spectrum
The ftsI locus of gram-negative bacteria encodes penicillin-binding protein 3 (PBP3), a common target of β-lactam antibiotics. Recent genomic surveillance of carbapenem-resistant Pseudomonas aeruginosa revealed that 17% of strains possessed nonsynonymous
Hirokazu Yano, Noboru Nakata, Koji Yahara, Motoyuki Sugai, Yukari Sato   +4 more
doaj   +2 more sources

Genomic profiling of cefotaxime-resistant Haemophilus influenzae from Norway and Sweden reveals extensive expansion of virulent multidrug-resistant international clones [PDF]

Frontiers in Microbiology
Cefotaxime-resistant Haemophilus influenzae (CRHI) are a global concern, but little is known about their molecular epidemiology. The goal of this study was to perform genomic profiling of 191 CRHI from Norway (n = 183) or Sweden (n = 8) (2006–2018) and ...
Dagfinn Skaare, Dagfinn Skaare, Inger Lill Anthonisen, Nermin Zecic, Andrew Jenkins, Dominique A. Caugant, Dominique A. Caugant, Trond Egil Ranheim, Arnfinn Sundsfjord, Arnfinn Sundsfjord, Arnfinn Sundsfjord, Kristin Hegstad, Kristin Hegstad, Kristin Hegstad, Study Group on Exceptional Phenotypes in Haemophilus influenzae, Truls Michael Leegaard, Tine Smedsund Dons, Paul Christoffer Lindemann, Karianne Wiger Gammelsrud, Kjersti Wik Larssen, Iren Høyland Löhr, Kyriakos Zaragkoulias, Roar Magne Bævre-jensen, Sara Debes, Reidar Hjetland, Annika Carlsson Wistedt, Ståle Tofteland, Liv Jorunn Hafne, Gunnar Skov Simonsen, Einar Nilsen, Brynja Ármannsdóttir, Martin Sundqvist, Anna Åkerlund, Carina Thilesen, Sandra Åsheim   +34 more
doaj   +2 more sources

Structural analysis of the boronic acid β-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3.

PLoS ONE, 2021
Antimicrobial resistance (AMR) mediated by β-lactamases is the major and leading cause of resistance to penicillins and cephalosporins among Gram-negative bacteria.
Vijay Kumar, Samantha L Viviani, Jeeda Ismail, Shreya Agarwal, Robert A Bonomo, Focco van den Akker   +5 more
doaj   +3 more sources

β-Lactamase-Producing <i>Haemophilus influenzae</i> Pneumonia in a 1-Month-Old Infant With Respiratory Syncytial Virus Bronchiolitis. [PDF]

J Gen Fam Med
Journal of General and Family Medicine, Volume 27, Issue 3, May 2026.
Zensho K, Nojima N, Hino R, Isse N.
europepmc   +2 more sources

Occurrence of High Levels of Cefiderocol Resistance in Carbapenem-Resistant Escherichia coli before Its Approval in China: a Report from China CRE-Network

Microbiology Spectrum, 2022
Cefiderocol has been approved in the United States and Europe but not in China. We aim to evaluate carbapenem-resistant Enterobacterales (CRE) susceptibility to cefiderocol to provide baseline data and investigate the resistance mechanism.
Qi Wang, Longyang Jin, Shijun Sun, Yuyao Yin, Ruobing Wang, Fengning Chen, Xiaojuan Wang, Yawei Zhang, Jun Hou, Yumei Zhang, Zhijie Zhang, Liuchun Luo, Zhusheng Guo, Zhenpeng Li, Xin Lin, Lei Bi, Hui Wang   +16 more
doaj   +1 more source

PBP5 Complementation of a PBP3 Deficiency inEnterococcus hirae [PDF]

Journal of Bacteriology, 2006
ABSTRACTThe low susceptibility of enterococci to β-lactams is due to the activity of the low-affinity penicillin-binding protein 5 (PBP5). One important feature of PBP5 is its ability to substitute for most, if not all, penicillin-binding proteins when they are inhibited.
Leimanis, Serge, Hoyez, Nathalie, Hubert, Severine, Laschet, M., Sauvage, Eric, Brasseur, Robert, Coyette, Jacques   +6 more
openaire   +2 more sources