Results 41 to 50 of about 2,944 (157)
Biomolecules, 2021 Novel antimicrobial strategies are urgently required because of the rising threat of multi drug resistant bacterial strains and the infections caused by them.
Stefan Freischem +7 more
doaj +1 more source
Frontiers in Public Health, 2022 BackgroundThe widespread use of antimicrobials and Haemophilus influenzae type b (Hib) vaccine worldwide has altered the epidemiological patterns of invasive H. influenzae.
Yuhong Zhou +5 more
doaj +1 more source
A Specialized Peptidoglycan Synthase Promotes
mBio, 2017 Bacterial cell division has been studied extensively under laboratory conditions. Despite being a key event in the bacterial cell cycle, cell division has not been explored in vivo in bacterial pathogens interacting with their hosts.
Sónia Castanheira +7 more
doaj +1 more source
Characterization of Escherichia coli NDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3 [PDF]
Journal of Antimicrobial Chemotherapy, 2015 Abstract Objectives The spread of NDM-1 amongst Enterobacteriaceae has highlighted a significant threat to the clinical management of serious infections. The combination of aztreonam and avibactam, a non-β-lactam β-lactamase inhibitor, may provide a much-needed therapeutic alternative.
Richard A, Alm +2 more
openaire +2 more sources
mBio, 2021 Antibiotic resistance is a significant clinical problem. Developing novel antibiotics that overcome known resistance mechanisms is highly desired.
Malligarjunan Rajavel +12 more
openaire +3 more sources
Journal of Global Antimicrobial Resistance, 2021 Objectives: While aztreonam-avibactam is a potent β-lactam-β-lactamase-inhibitor combination, reduced in vitro activity against some Enterobacterales isolates has been reported. In this study, globally collected clinical isolates of Enterobacterales with
Mark Estabrook +5 more
doaj +1 more source
mBio, 2019 Peptidoglycan (PG) is an essential constituent of the bacterial cell wall. During cell division, PG synthesis localizes at midcell under the control of a multiprotein complex, the divisome, allowing the safe formation of two new cell poles and separation
Adrien Boes +3 more
doaj +1 more source
Localization of FtsI (PBP3) to the Septal Ring Requires Its Membrane Anchor, the Z Ring, FtsA, FtsQ, and FtsL [PDF]
Journal of Bacteriology, 1999 ABSTRACT Assembly of the division septum in bacteria is mediated by several proteins that localize to the division site. One of these, FtsI (also called penicillin-binding protein 3) of Escherichia coli , consists of a short cytoplasmic domain, a single membrane-spanning segment, and a large periplasmic ...
D S, Weiss +4 more
openaire +2 more sources
Frontiers in Microbiology, 2022 Invasive Haemophilus influenzae (Hi) disease has decreased in countries that included Hi type b (Hib) vaccination in their childhood immunization programs in the 1990s. Non-typeable (NT) and non-b strains are now the leading causes of invasive Hi disease
Ragnhild Tønnessen +6 more
doaj +1 more source
Neisseria gonorrhoeae PBP3 and PBP4 Facilitate NOD1 Agonist Peptidoglycan Fragment Release and Survival in Stationary Phase [PDF]
Infection and Immunity, 2019 Neisseria gonorrhoeae releases peptidoglycan fragments during growth, and these molecules induce an inflammatory response in the human host. The proinflammatory molecules include peptidoglycan monomers, peptidoglycan dimers, and free peptides.
Ryan E. Schaub +4 more
openaire +2 more sources