Results 41 to 50 of about 5,166 (218)

Tracing the evolutionary trajectory of the IncP-2 plasmid co-harboring blaIMP-45 and blaVIM-1: an outbreak of Pseudomonas aeruginosa co-producing IMP-45 and VIM-1 carbapenemases in China [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundCarbapenem-resistant Pseudomonas aeruginosa (CRPA) poses a significant global health risk, particularly for immunocompromised individuals. This study documents an outbreak of CRPA strains co-harboring blaVIM-1 and blaIMP-45 on IncP-2 plasmids ...
Yiqun Ma, Yiqun Ma, Yiqun Ma, Zichen Lei, Zichen Lei, Zichen Lei, Yulin Zhang, Yulin Zhang, Qi Liu, Qi Liu, Qi Liu, Feilong Zhang, Feilong Zhang, Feilong Zhang, Hao Zu, Xinrui Yang, Xinrui Yang, Xinrui Yang, Ziyao Li, Ziyao Li, Ziyao Li, Binghuai Lu, Binghuai Lu, Binghuai Lu, Binghuai Lu, Binghuai Lu   +25 more
doaj   +2 more sources

Molecular Cytology of ‘Little Animals’: Personal Recollections of Escherichia coli (and Bacillus subtilis)

Life, 2023
This article relates personal recollections and starts with the origin of electron microscopy in the sixties of the previous century at the University of Amsterdam.
Nanne Nanninga
doaj   +1 more source

Image-based dynamic phenotyping reveals genetic determinants of filamentation-mediated beta-lactam tolerance [PDF]

, 2020
Antibiotic tolerance characterized by slow killing of bacteria in response to a drug can lead to treatment failure and promote the emergence of resistance.
Camacho, Rafael, Fauvart, Maarten, Franke, Sabine, Hofkens, Johan, Marchal, Kathleen, Michielsen, Jan, Weytjens, Bram, Wilmaerts, Dorien, Zahir, Taiyeb   +8 more
core   +2 more sources

Synthesis and penicillin‐binding protein inhibitory assessment of dipeptidic 4‐phenyl‐β‐lactams from α‐amino acid‐derived imines [PDF]

, 2020
Monocyclic beta-lactams revive the research field on antibiotics, which are threatened by the emergence of resistant bacteria. A six-step synthetic route was developed, providing easy access to new 3-amino-1-carboxymethyl-4-phenyl-beta-lactams, of which ...
Amoroso, Ana Maria, D'hooghe, Matthias, Decuyper, Lena, Gobec, Stanislav, Joris, Bernard, Jukič, Marko, Sosič, Izidor, Verlaine, Olivier   +7 more
core   +2 more sources

Development and validation of a pentaplex PCR assay for rapid detection of blaCTX-M, blaOXA–1, blaCMY, blaNDM and the PBP3 insert in Enterobacterales

Indian Journal of Medical Microbiology
Ayyanraj Neeravi, Nivedhana Subburaju
exaly   +2 more sources

Resistance to aztreonam-avibactam due to CTX-M-15 in the presence of penicillin-binding protein 3 with extra amino acids in Escherichia coli

Frontiers in Microbiology, 2022
Aztreonam-avibactam is a promising combination to treat carbapenem-resistant Enterobacterales including coverage for metallo-β-lactamases. Escherichia coli strains resistant to aztreonam-avibactam have emerged but resistance mechanisms remain to be ...
Ke Ma, Zhiyong Zong, Zhiyong Zong, Zhiyong Zong   +3 more
doaj   +1 more source

Interaction between two murein (peptidoglycan) synthases, PBP3 and PBP1B, in Escherichia coli [PDF]

Molecular Microbiology, 2006
SummaryThe murein (peptidoglycan) sacculus is an essential polymer embedded in the bacterial envelope. The Escherichia coli class B penicillin‐binding protein (PBP) 3 is a murein transpeptidase and essential for cell division. In an affinity chromatography experiment, the bifunctional transglycosylase‐transpeptidase murein synthase PBP1B was retained ...
Bertsche, U., Kast, T., Wolf, B., Fraipont, C., Aarsman, M.E.G., Kannenberg, K., von Rechenberg, M., Nguyen-Distèche, M., den Blaauwen, T., Höltje, J-V., Vollmer, W.   +10 more
openaire   +7 more sources

Staphylococcus aureus Survives with a Minimal Peptidoglycan Synthesis Machine but Sacrifices Virulence and Antibiotic Resistance [PDF]

, 2015
Many important cellular processes are performed by molecular machines, composed of multiple proteins that physically interact to execute biological functions. An example is the bacterial peptidoglycan (PG) synthesis machine, responsible for the synthesis
A Antignac, A Bera, A Typas, AM Jorge, Andreas Peschel, AR Pereira, AW Wyke, B Langmead, BJ Hartman, CI Chang, DC McPherson, DJ Scheffers, DY Wu, E Kuru, Egbert Hoiczyk, G Memmi, G Sakoulas, H Komatsuzawa, H Komatsuzawa, H Labischinski, HW Boucher, I Kounatidis, IG Boneca, IG Boneca, IG Boneca, J Gough, José B. Pereira-Leal, JV Holtje, JV Holtje, LB Rice, M El Ghachi, M Kuroda, M Kuroda, M Vicente, M Wu, Magda L. Atilano, Mariana G. Pinho, MG Pinho, MG Pinho, MG Pinho, MG Pinho, MG Pinho, ML Atilano, ML Atilano, NAC Curtis, Nathalie T. Reichmann, NW Goehring, P Giesbrecht, P Matthews, P Reed, Patricia Reed, Pedro M. Pereira, Petros Ligoxygakis, PM Coutinho, R Tam, RA Forsyth, Renato Alves, S Borukhov, S Guindon, SFF Pereira, SFF Pereira, SR Eddy, SR Filipe, Sérgio R. Filipe, T Michel, Terry Roemer, TF Mackay, VR Steele, W Strobel, X Fan, Xinwei Sher, Z Kelman   +71 more
core   +8 more sources

Staphylococcus aureus Cell Wall Biosynthesis Modulates Bone Invasion and Osteomyelitis Pathogenesis

Frontiers in Microbiology, 2021
Staphylococcus aureus invasion of the osteocyte lacuno-canalicular network (OLCN) is a novel mechanism of bacterial persistence and immune evasion in chronic osteomyelitis. Previous work highlighted S.
Elysia A. Masters, Elysia A. Masters, Gowrishankar Muthukrishnan, Gowrishankar Muthukrishnan, Lananh Ho, Lananh Ho, Ann Lindley Gill, Karen L. de Mesy Bentley, Karen L. de Mesy Bentley, Karen L. de Mesy Bentley, Chad A. Galloway, Chad A. Galloway, James L. McGrath, Hani A. Awad, Hani A. Awad, Steven R. Gill, Edward M. Schwarz, Edward M. Schwarz, Edward M. Schwarz, Edward M. Schwarz   +19 more
doaj   +1 more source

Re-evaluation of the significance of penicillin binding protein 3 in the susceptibility of Listeria monocytogenes to β-lactam antibiotics

BMC Microbiology, 2012
Background Penicillin binding protein 3 (PBP3) of L. monocytogenes has long been thought of as the primary lethal target for β-lactam antibiotics due to the excellent correlation between the MICs of different β-lactams and their affinity for this protein.
Krawczyk-Balska Agata, Popowska Magdalena, Markiewicz Zdzislaw   +2 more
doaj   +1 more source