Results 31 to 40 of about 5,166 (218)

Neisseria gonorrhoeae PBP3 and PBP4 Facilitate NOD1 Agonist Peptidoglycan Fragment Release and Survival in Stationary Phase [PDF]

Infection and Immunity, 2018
Neisseria gonorrhoeae releases peptidoglycan fragments during growth, and these molecules induce an inflammatory response in the human host. The proinflammatory molecules include peptidoglycan monomers, peptidoglycan dimers, and free peptides.
Ryan E. Schaub, Krizia M. Perez-Medina, Kathleen T. Hackett, Daniel López García, Joseph P. Dillard   +4 more
openalex   +3 more sources

Characterization of Escherichia coli NDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3 [PDF]

Journal of Antimicrobial Chemotherapy, 2015
Abstract Objectives The spread of NDM-1 amongst Enterobacteriaceae has highlighted a significant threat to the clinical management of serious infections. The combination of aztreonam and avibactam, a non-β-lactam β-lactamase inhibitor, may provide a much-needed therapeutic alternative.
Richard A. Alm, Michele Johnstone, Sushmita D. Lahiri   +2 more
openalex   +4 more sources

The d,d‐carboxypeptidase PBP3 organizes the division process of Streptococcus pneumoniae [PDF]

Molecular Microbiology, 2004
SummaryBacterial division requires the co‐ordination of membrane invagination, driven by the constriction of the FtsZ‐ring, and concomitant cell wall synthesis, performed by the high‐molecular‐weight penicillin‐binding proteins (HMW PBPs). Using immunofluorescence techniques, we show in Streptococcus pneumoniae that this co‐ordination requires PBP3, a ...
Cécile Morlot, Marjolaine Noirclerc‐Savoye, André Zapun, O. Dideberg, Thierry Vernet   +4 more
openalex   +3 more sources

High in vitro activity of aztreonam/avibactam against NDM-producing Enterobacterales with emerging resistance in Escherichia coli in the United States Mid-Atlantic region [PDF]

Microbiology Spectrum
New Delhi metallo-β-lactamase (NDM)-producing Enterobacterales represent a critical antimicrobial resistance threat with limited therapeutic options. Aztreonam/avibactam, which combines the stability of aztreonam against metallo-β-lactamases with the ...
Eetu Eklund, Tyler Maruca, Kate Kruczynski, Heather Critchfield, Robert Murphy, Eric Keller, Benjamin Lee, Ami Patel, Liore Klein, David A. Torpey, Robert A. Myers, Victoria L. Campodónico   +11 more
doaj   +2 more sources

Genomic profiling of cefotaxime-resistant Haemophilus influenzae from Norway and Sweden reveals extensive expansion of virulent multidrug-resistant international clones [PDF]

Frontiers in Microbiology
Cefotaxime-resistant Haemophilus influenzae (CRHI) are a global concern, but little is known about their molecular epidemiology. The goal of this study was to perform genomic profiling of 191 CRHI from Norway (n = 183) or Sweden (n = 8) (2006–2018) and ...
Dagfinn Skaare, Dagfinn Skaare, Inger Lill Anthonisen, Nermin Zecic, Andrew Jenkins, Dominique A. Caugant, Dominique A. Caugant, Trond Egil Ranheim, Arnfinn Sundsfjord, Arnfinn Sundsfjord, Arnfinn Sundsfjord, Kristin Hegstad, Kristin Hegstad, Kristin Hegstad, Study Group on Exceptional Phenotypes in Haemophilus influenzae, Truls Michael Leegaard, Tine Smedsund Dons, Paul Christoffer Lindemann, Karianne Wiger Gammelsrud, Kjersti Wik Larssen, Iren Høyland Löhr, Kyriakos Zaragkoulias, Roar Magne Bævre-jensen, Sara Debes, Reidar Hjetland, Annika Carlsson Wistedt, Ståle Tofteland, Liv Jorunn Hafne, Gunnar Skov Simonsen, Einar Nilsen, Brynja Ármannsdóttir, Martin Sundqvist, Anna Åkerlund, Carina Thilesen, Sandra Åsheim   +34 more
doaj   +2 more sources

Specific variants in ftsI reduce carbapenem susceptibility in Pseudomonas aeruginosa [PDF]

Microbiology Spectrum
The ftsI locus of gram-negative bacteria encodes penicillin-binding protein 3 (PBP3), a common target of β-lactam antibiotics. Recent genomic surveillance of carbapenem-resistant Pseudomonas aeruginosa revealed that 17% of strains possessed nonsynonymous
Hirokazu Yano, Noboru Nakata, Koji Yahara, Motoyuki Sugai, Yukari Sato   +4 more
doaj   +2 more sources

Localization and Single Molecule Dynamics of Bacillus subtilis Penicillin-Binding Proteins Depend on Substrate Availability and Are Affected by Stress Conditions [PDF]

Cells
We have used single molecule tracking to investigate dynamics of four penicillin-binding proteins (PBPs) in Bacillus subtilis to shed light on their possible modes of action.
Lisa Stuckenschneider, Peter L. Graumann
doaj   +2 more sources

High prevalence of Escherichia coli clinical isolates in India harbouring four amino acid inserts in PBP3 adversely impacting activity of aztreonam/avibactam [PDF]

Journal of Antimicrobial Chemotherapy, 2020
Hariharan Periasamy, Rahul Shrivastava, Sachin S Bhagwat   +2 more
exaly   +2 more sources

Structural analysis of the boronic acid β-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3.

PLoS ONE, 2021
Antimicrobial resistance (AMR) mediated by β-lactamases is the major and leading cause of resistance to penicillins and cephalosporins among Gram-negative bacteria.
Vijay Kumar, Samantha L Viviani, Jeeda Ismail, Shreya Agarwal, Robert A Bonomo, Focco van den Akker   +5 more
doaj   +3 more sources

Occurrence of High Levels of Cefiderocol Resistance in Carbapenem-Resistant Escherichia coli before Its Approval in China: a Report from China CRE-Network

Microbiology Spectrum, 2022
Cefiderocol has been approved in the United States and Europe but not in China. We aim to evaluate carbapenem-resistant Enterobacterales (CRE) susceptibility to cefiderocol to provide baseline data and investigate the resistance mechanism.
Qi Wang, Longyang Jin, Shijun Sun, Yuyao Yin, Ruobing Wang, Fengning Chen, Xiaojuan Wang, Yawei Zhang, Jun Hou, Yumei Zhang, Zhijie Zhang, Liuchun Luo, Zhusheng Guo, Zhenpeng Li, Xin Lin, Lei Bi, Hui Wang   +16 more
doaj   +1 more source