Results 31 to 40 of about 2,944 (157)

The integral membrane FtsW protein and peptidoglycan synthase PBP3 form a subcomplex in Escherichia coli [PDF]

Microbiology, 2011
During the cell cycle of rod-shaped bacteria, two morphogenetic processes can be discriminated: length growth of the cylindrical part of the cell and cell division by formation of two new cell poles. The morphogenetic protein complex responsible for the septation during cell division (the divisome) includes class A and class B penicillin-binding ...
Fraipont, C., Alexeeva, S., Wolf, B., van der Ploeg, R., Schloesser, M., den Blaauwen, T., Nguyen-Distèche, M.   +6 more
openaire   +4 more sources

Re-evaluation of the significance of penicillin binding protein 3 in the susceptibility of Listeria monocytogenes to β-lactam antibiotics

BMC Microbiology, 2012
Background Penicillin binding protein 3 (PBP3) of L. monocytogenes has long been thought of as the primary lethal target for β-lactam antibiotics due to the excellent correlation between the MICs of different β-lactams and their affinity for this protein.
Krawczyk-Balska Agata, Popowska Magdalena, Markiewicz Zdzislaw   +2 more
doaj   +1 more source

Staphylococcus aureus Cell Wall Biosynthesis Modulates Bone Invasion and Osteomyelitis Pathogenesis

Frontiers in Microbiology, 2021
Staphylococcus aureus invasion of the osteocyte lacuno-canalicular network (OLCN) is a novel mechanism of bacterial persistence and immune evasion in chronic osteomyelitis. Previous work highlighted S.
Elysia A. Masters, Elysia A. Masters, Gowrishankar Muthukrishnan, Gowrishankar Muthukrishnan, Lananh Ho, Lananh Ho, Ann Lindley Gill, Karen L. de Mesy Bentley, Karen L. de Mesy Bentley, Karen L. de Mesy Bentley, Chad A. Galloway, Chad A. Galloway, James L. McGrath, Hani A. Awad, Hani A. Awad, Steven R. Gill, Edward M. Schwarz, Edward M. Schwarz, Edward M. Schwarz, Edward M. Schwarz   +19 more
doaj   +1 more source

Characterization of Serotypes and Molecular Drug Resistance Patterns of Haemophilus influenzae in Kunming Children

Polish Journal of Microbiology, 2023
The present study aimed to determine the capsular serotype distribution and antimicrobial drug resistance patterns of Haemophilus influenzae from children in the Kunming region of China. This information could guide policymakers in clinical treatment. In
Yuan Mei, Ma Mingbiao, Jiang Hongchao, Fan Mao, Sun Ying, Zhou Bailing, Feng Xingxing, Yang Junyi, Su Min, He Xiaoli   +9 more
doaj   +1 more source

SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3 [PDF]

ACS Medicinal Chemistry Letters, 2015
A main challenge in the development of new agents for the treatment of Pseudomonas aeruginosa infections is the identification of chemotypes that efficiently penetrate the cell envelope and are not susceptible to established resistance mechanisms. Siderophore-conjugated monocarbams are attractive because of their ability to hijack the bacteria's iron ...
Kerry E, Murphy-Benenato, Brian, Dangel, Hajnalka E, Davis, Thomas F, Durand-Réville, Andrew D, Ferguson, Ning, Gao, Haris, Jahić, John P, Mueller, Erika L, Manyak, Olga, Quiroga, Michael, Rooney, Li, Sha, Mark, Sylvester, Frank, Wu, Mark, Zambrowski, Shannon X, Zhao   +15 more
openaire   +2 more sources

Interaction between membrane proteins PBP3 and rodA is required for normal cell shape and division in Escherichia coli [PDF]

Journal of Bacteriology, 1986
In Escherichia coli, the products of several genes are required for septation, and the products of several others are required for the maintenance of the rod shape of the cells. We show here that the combination of certain mutations in a division gene (ftsI) with a specific mutation in one of the shape genes (rodA) could produce cells with normal shape
Begg, KJ, Spratt, BG, Donachie, WD
openaire   +3 more sources

Molecular epidemiology of nontypeable Haemophilus influenzae causing community-acquired pneumonia in adults. [PDF]

PLoS ONE, 2013
Nontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen which causes a variety of respiratory infections. The objectives of the study were to determine its antimicrobial susceptibility, to characterize the β-lactam resistance, and to ...
Carmen Puig, Laura Calatayud, Sara Martí, Fe Tubau, Carolina Garcia-Vidal, Jordi Carratalà, Josefina Liñares, Carmen Ardanuy   +7 more
doaj   +1 more source

Localization of PBP3 in Caulobacter crescentus is highly dynamic and largely relies on its functional transpeptidase domain [PDF]

Molecular Microbiology, 2008
SummaryIn rod‐shaped bacteria, septal peptidoglycan synthesis involves the late recruitment of the ftsI gene product (PBP3 in Escherichia coli) to the FtsZ ring. We show that in Caulobacter crescentus, PBP3 accumulates at the new pole at the beginning of the cell cycle.
Teresa, Costa, Richa, Priyadarshini, Christine, Jacobs-Wagner   +2 more
openaire   +2 more sources

Localization of the Escherichia coli cell division protein FtsI (PBP3) to the division site and cell pole [PDF]

Molecular Microbiology, 1997
FtsI, also known as penicillin‐binding protein 3, is a transpeptidase required for the synthesis of peptidoglycan in the division septum of the bacterium, Escherichia coli. FtsI has been estimated to be present at about 100 molecules per cell, well below the detection limit of immunoelectron microscopy.
D S, Weiss, K, Pogliano, M, Carson, L M, Guzman, C, Fraipont, M, Nguyen-Distèche, R, Losick, J, Beckwith   +7 more
openaire   +2 more sources

Molecular Epidemiology and Antimicrobial Resistance of Haemophilus influenzae in Adult Patients in Shanghai, China

Frontiers in Public Health, 2020
Background: The serotype and antimicrobial resistance of Haemophilus influenzae in adult patients have changed due to the application of antimicrobials and H. influenzae type b (Hib) vaccine worldwide.
Xin-Xin Li, Shu-Zhen Xiao, Fei-Fei Gu, Wei-Ping He, Yu-Xing Ni, Li-Zhong Han   +5 more
doaj   +1 more source