Results 51 to 60 of about 2,944 (157)

Studi Interaksi Molekuler Aktivitas Antimikroba Peptida Bioaktif terhadap Staphylococcus aureus Secara In silico

Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2020
Pendahuluan: Lendir kulit ikan lele kuning (Pelteobagrus fulvidraco), mengandung peptida bioaktif dan banyak dimanfaatkan dalam pengobatan berbagai penyakit karena memiliki aktivitas biologis, diantaranya sebagai antimikroba.
Taufik Muhammad Fakih, Mentari Luthfika Dewi   +1 more
doaj   +1 more source

PBP Target Profiling by β-Lactam and β-Lactamase Inhibitors in Intact Pseudomonas aeruginosa: Effects of the Intrinsic and Acquired Resistance Determinants on the Periplasmic Drug Availability

Microbiology Spectrum, 2023
The lack of effective treatment options against Pseudomonas aeruginosa is one of the main contributors to the silent pandemic. Many antibiotics are ineffective against resistant isolates due to poor target site penetration, efflux, or β-lactamase ...
Maria Montaner, Silvia Lopez-Argüello, Antonio Oliver, Bartolome Moya   +3 more
doaj   +1 more source

In Vivo Cross‐Linking Sheds Light on the Salmonella Divisome in Which PBP3 and PBP3_SAL Compete for Occupancy

Molecular Microbiology
ABSTRACTBacterial cell division is orchestrated by proteins that assemble in dynamic complexes collectively known as the divisome. Essential monofunctional enzymes with glycosyltransferase or transpeptidase (TPase) activities, FtsW and FtsI respectively, engage in the synthesis of septal peptidoglycan (sPG).
Sónia Castanheira, David López‐Escarpa, Alberto Paradela, Francisco García‐del Portillo   +3 more
openaire   +3 more sources

Imipenem heteroresistance in nontypeable Haemophilus influenzae is linked to a combination of altered PBP3, slow drug influx and direct efflux regulation [PDF]

Clinical Microbiology and Infection, 2017
To investigate the potential roles of PBPs, efflux pumps and slow drug influx for imipenem heteroresistance in nontypeable Haemophilus influenzae (NTHi).Fifty-nine NTHi clinical isolates examined in this study were collected at Geneva University Hospitals between 2009 and 2014. Alterations in PBPs were investigated by gene sequencing.
Cherkaoui, Abdessalam, Diene, S M, Renzoni, Adriana Maria, Emonet, Stéphane, Renzi, Gesuele, Francois, Patrice, Schrenzel, Jacques   +6 more
openaire   +4 more sources

SanA Plays a Role in Peptidoglycan Integrity in Escherichia coli

Molecular Microbiology, Volume 125, Issue 4, Page 343-357, April 2026.
SanA is a novel regulator of peptidoglycan synthesis, potentially through functional interplay with PBP1B‐dependent pathways. ABSTRACT Peptidoglycan synthesis and degradation are both essential for bacterial growth, and damaged peptidoglycan must be continuously repaired. In Escherichia coli, peptidoglycan required for cell elongation is synthesized by
Honoka Yamaguchi, Risa Ago, Yuhei O. Tahara, Mari Inoue, Hironori Niki, Makoto Miyata, Daisuke Shiomi   +6 more
wiley   +1 more source

Revisiting mutational resistance to ampicillin and cefotaxime in Haemophilus influenzae

Genome Medicine
Background Haemophilus influenzae is an opportunistic bacterial pathogen that can cause severe respiratory tract and invasive infections. The emergence of β-lactamase-negative ampicillin-resistant (BLNAR) strains and unclear correlations between ...
Margo Diricks, Sabine Petersen, Lennart Bartels, Thiên-Trí Lâm, Heike Claus, Maria Paula Bajanca-Lavado, Susanne Hauswaldt, Ricardo Stolze, Omar Jiménez Vázquez, Christian Utpatel, Stefan Niemann, Jan Rupp, Inken Wohlers, Matthias Merker   +13 more
doaj   +1 more source

Bismuth Bicycles

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
Discovery, evolution and potential future applications of bismuth bicycle molecules—a novel class of therapeutics with unique properties. ABSTRACT Bicyclic peptides are emerging as next generation therapeutics by combining the affinity and specificity of antibodies with the synthetic convenience of small molecules.
Saan Voss, Amin Sagar, Arnaud Tiberghien, Richard J. L. Hughes, Liuhong Chen, Inmaculada Rioja, Mark Frigerio, Michael J. Skynner, David R. Spring   +8 more
wiley   +1 more source

A Hunt for the Resistance of Haemophilus influnezae to Beta-Lactams

Antibiotics
Infections due to Haemophilus influnezae require prompt treatment using beta-lactam antibiotics. We used a collection of 81 isolates obtained between 1940 and 2001 from several countries.
Mélanie Denizon, Eva Hong, Aude Terrade, Muhamed-Kheir Taha, Ala-Eddine Deghmane   +4 more
doaj   +1 more source

Integrated Bioprospection of Phenolics as Potent Modulators of Acinetobacter baumannii Penicillin‐Binding Protein 1A

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Diseases caused by carbapenem‐resistant Acinetobacter baumannii can lead to death within 48 h of hospitalization, with an overall mortality rate of 68%. The reduced affinity of carbapenem and other β‐lactams for penicillin‐binding proteins 1A (PBP1A), a critical protein, is a key resistance mechanism in A. baumannii.
Oladunni Ayodele, Saheed Sabiu, Sohini Basu Roy   +2 more
wiley   +1 more source

Impact of COVID‐19 on the Prevalence and Drug Resistance of Haemophilus influenzae in Shandong Province: A Multicenter Retrospective Study

Health Science Reports, Volume 8, Issue 11, November 2025.
ABSTRACT Background and Aims The COVID‐19 pandemic has profoundly impacted global public health, particularly the epidemiology and antimicrobial resistance patterns of pathogens. This study aimed to assess the influence of COVID‐19 on the isolation rates of Haemophilus influenzae in Shandong Province, providing data support for empirical precision ...
Yanmeng Sun, Mengyuan Wang, Zheng Li, Sijin Man, Shifu Wang   +4 more
wiley   +1 more source