Results 1 to 10 of about 2,281 (190)

Matrine reverses the resistance of Haemophilus parasuis to cefaclor by inhibiting the mutations in penicillin-binding protein genes (ftsI and mrcA) [PDF]

Frontiers in Microbiology
IntroductionMatrine (MT) is a potential resistance reversal agent. However, it remains unclear whether MT can reverse the resistance of Haemophilus parasuis (H.
Daojin Yu
exaly   +8 more sources

High level non-carbapenemase carbapenem resistance by overlaying mutations of mexR, oprD, and ftsI in Pseudomonas aeruginosa [PDF]

Microbiology Spectrum
Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a global threat, but the mechanism of non-carbapenemase carbapenem resistance is still unclear. In the current study, we investigated the contributions of point mutations in mexR, oprD, and ftsI to ...
Yan Yang, Xue Li, Lang Sun, Xiu-Kun Wang, You-Wen Zhang, Jing Pang, Guo-Qing Li, Xin-Xin Hu, Tong-Ying Nie, Xin-Yi Yang, Jian-Hua Liu, Gerrit Brandis, Xue-Fu You, Cong-Ran Li   +13 more
doaj   +6 more sources

Specific variants in ftsI reduce carbapenem susceptibility in Pseudomonas aeruginosa [PDF]

Microbiology Spectrum
The ftsI locus of gram-negative bacteria encodes penicillin-binding protein 3 (PBP3), a common target of β-lactam antibiotics. Recent genomic surveillance of carbapenem-resistant Pseudomonas aeruginosa revealed that 17% of strains possessed nonsynonymous
Hirokazu Yano, Noboru Nakata, Koji Yahara, Motoyuki Sugai, Yukari Sato   +4 more
doaj   +4 more sources

High in vitro activity of aztreonam/avibactam against NDM-producing Enterobacterales with emerging resistance in Escherichia coli in the United States Mid-Atlantic region [PDF]

Microbiology Spectrum
New Delhi metallo-β-lactamase (NDM)-producing Enterobacterales represent a critical antimicrobial resistance threat with limited therapeutic options. Aztreonam/avibactam, which combines the stability of aztreonam against metallo-β-lactamases with the ...
Eetu Eklund, Tyler Maruca, Kate Kruczynski, Heather Critchfield, Robert Murphy, Eric Keller, Benjamin Lee, Ami Patel, Liore Klein, David A. Torpey, Robert A. Myers, Victoria L. Campodónico   +11 more
doaj   +2 more sources

Impaired envelope integrity in the absence of SanA is linked to increased lipid II availability and an imbalance of septal peptidoglycan synthesis [PDF]

mBio
In gram-negative bacteria, the outer membrane (OM) acts in conjunction with the peptidoglycan (PG) cell wall as a barrier against physical, osmotic, and chemical environmental stressors, including antibiotics.
Joseph F. Carr, Carolina Basurto De Santiago, Shivani A. Bhut, Daniel J. Warzecha, Sarah A. Vastani, Robert Wei, Carmen M. Herrera, M. Stephen Trent, Beiyan Nan, Angela M. Mitchell   +9 more
doaj   +2 more sources

Characteristics of Haemophilus influenzae Isolates Responsible for Invasive Infections in Poland in 2018–2023 [PDF]

Infectious Diseases and Therapy
Introduction Haemophilus influenzae is a human-specific Gram-negative bacterium responsible for respiratory tract infection, sepsis, and meningitis. The study aimed to investigate the epidemiology, serotype distribution, and mechanisms of beta-lactam ...
Marlena Kiedrowska, Kinga Błaszczyk, Agnieszka Gołębiewska, Waleria Hryniewicz, Alicja Kuch, Patrycja Ronkiewicz, Izabela Wróbel-Pawelczyk, Anna Skoczyńska   +7 more
doaj   +2 more sources

Genomic profiling of cefotaxime-resistant Haemophilus influenzae from Norway and Sweden reveals extensive expansion of virulent multidrug-resistant international clones [PDF]

Frontiers in Microbiology
Cefotaxime-resistant Haemophilus influenzae (CRHI) are a global concern, but little is known about their molecular epidemiology. The goal of this study was to perform genomic profiling of 191 CRHI from Norway (n = 183) or Sweden (n = 8) (2006–2018) and ...
Dagfinn Skaare, Dagfinn Skaare, Inger Lill Anthonisen, Nermin Zecic, Andrew Jenkins, Dominique A. Caugant, Dominique A. Caugant, Trond Egil Ranheim, Arnfinn Sundsfjord, Arnfinn Sundsfjord, Arnfinn Sundsfjord, Kristin Hegstad, Kristin Hegstad, Kristin Hegstad, Study Group on Exceptional Phenotypes in Haemophilus influenzae, Truls Michael Leegaard, Tine Smedsund Dons, Paul Christoffer Lindemann, Karianne Wiger Gammelsrud, Kjersti Wik Larssen, Iren Høyland Löhr, Kyriakos Zaragkoulias, Roar Magne Bævre-jensen, Sara Debes, Reidar Hjetland, Annika Carlsson Wistedt, Ståle Tofteland, Liv Jorunn Hafne, Gunnar Skov Simonsen, Einar Nilsen, Brynja Ármannsdóttir, Martin Sundqvist, Anna Åkerlund, Carina Thilesen, Sandra Åsheim   +34 more
doaj   +2 more sources

Within-patient evolution of Pseudomonas aeruginosa populations during antimicrobial treatment [PDF]

mSphere
Multidrug-resistant (MDR) Pseudomonas aeruginosa infections pose a major challenge to effective treatment. Understanding genomic adaptations during antimicrobial therapy in patients infected with this pathogen is crucial for preventing therapeutic ...
Giuseppe Fleres, Ellen G. Kline, Kevin M. Squires, Tyler Tate, Hannah M. Creager, Ryan K. Shields, Daria Van Tyne   +6 more
doaj   +2 more sources

Antimicrobial resistance characteristics and associated molecular mechanisms of clinically isolated Haemophilus influenzae from the lower respiratory tract in Chongqing, China [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundGlobal systematic research on Haemophilus influenzae drug resistance profiles and mechanisms is scarce. Many studies are constrained by single-center designs and restricted sample numbers, hindering the proper monitoring of drug resistance ...
Qiong Huang, Rong Xiang, Yong Wu, Wenfeng Zhang, Wei Xie, Zhiyong Liu, Nian Quan, Yuan Gao, Zhongzheng Xiong, Li He, Jing Fu, Di Mu, Yunying Wang   +12 more
doaj   +2 more sources

Antibacterial activities of novel peptide nucleic acids targeting Salmonella penicillin-binding proteins [PDF]

Molecular Therapy: Nucleic Acids
Salmonella is a significant global enteric pathogen with a high incidence of multidrug resistance (MDR), which limits therapeutic options and necessitates the development of novel treatments. Antisense peptide nucleic acids (PNAs), which target essential
Mohamed El-Fateh, Charles Viau, Nada Ahmed, Jianguo Xia, Xin Zhao   +4 more
doaj   +2 more sources