Results 31 to 40 of about 2,281 (190)

Lower respiratory tract isolates of non-typeable Haemophilus influenzae in Western Sichuan, China: Antimicrobial susceptibility, mechanisms of β-lactam resistance and decade changes

Journal of Global Antimicrobial Resistance, 2020
Objectives: The aims of this study were to analyse the serotypes of epidemic Haemophilus influenzae and changes in mechanisms of β-lactam resistance over the past decade. Results: Haemophilus influenzae isolates in Western Sichuan from 2013–2014 were non-
Xiao Lei Wang, Jiang Xie, Yuan Biao Guo, Bing Qing Zhu, Zhu Jun Shao, Hui Min Guo, Li Li Yang, Hua Wei Liu, Zhan Hao Wang, Jun Hu, Lu Fei Huang   +10 more
doaj   +1 more source

Morphological features and signature gene response elicited by inactivation of FtsI in Mycobacterium tuberculosis [PDF]

Journal of Antimicrobial Chemotherapy, 2008
Universally conserved events in cell division provide the opportunity for the development of novel chemotherapeutics against Mycobacterium tuberculosis. The aim of this study was to use the beta-lactam antimicrobials cefalexin and piperacillin to inhibit FtsI and characterize the morphological changes and global transcriptional activities of genes to ...
Richard A, Slayden, John T, Belisle
openaire   +2 more sources

Medium-Dependent Phenotypes of Streptomyces coelicolor with Mutations in ftsI or ftsW [PDF]

Journal of Bacteriology, 2009
ABSTRACT Streptomyces coelicolor A3(2) ftsI - and ftsW -null mutants produced aerial hyphae with no evidence of septation when grown on a traditional osmotically enhanced medium.
Jennifer A, Bennett, Jennifer, Yarnall, Adam B, Cadwallader, Rebecca, Kuennen, Peter, Bidey, Beth, Stadelmaier, Joseph R, McCormick   +6 more
openaire   +2 more sources

A conserved subcomplex within the bacterial cytokinetic ring activates cell wall synthesis by the FtsW-FtsI synthase [PDF]

Proceedings of the National Academy of Sciences, 2020
Significance Cell division is an essential process in bacteria and an attractive target for antibiotic development. A major activity of the division apparatus is the synthesis of the cell wall peptidoglycan that will ultimately fortify the poles of the daughter cells.
Lindsey S. Marmont, Thomas G. Bernhardt
openaire   +2 more sources

Mutations in porin LamB contribute to ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae

Emerging Microbes and Infections, 2021
Ceftazidime-avibactam (CAZ-AVI) shows promising activity against carbapenem-resistant Klebsiella pneumoniae (CRKP), however, CAZ-AVI resistance have emerged recently. Mutations in KPCs, porins OmpK35 and/or OmpK36, and PBPs are known to contribute to the
Yingyi Guo, Ningjing Liu, Zhiwei Lin, Xiaoliang Ba, Chuyue Zhuo, Feifeng Li, Jiong Wang, Yitan Li, Likang Yao, Baomo Liu, Shunian Xiao, Ying Jiang, Chao Zhuo   +12 more
doaj   +1 more source

The Transmembrane Helix of the Escherichia coli Division Protein FtsI Localizes to the Septal Ring [PDF]

Journal of Bacteriology, 2005
ABSTRACT FtsI (also called PBP3) of Escherichia coli is a transpeptidase required for synthesis of peptidoglycan in the division septum and is one of about a dozen division proteins that localize to the septal ring. FtsI comprises a short amino-terminal cytoplasmic domain, a
Mark C, Wissel, Jennifer L, Wendt, Calista J, Mitchell, David S, Weiss   +3 more
openaire   +3 more sources

Genetic analysis of the septal peptidoglycan synthase FtsWI complex supports a conserved activation mechanism for SEDS-bPBP complexes.

PLoS Genetics, 2021
SEDS family peptidoglycan (PG) glycosyltransferases, RodA and FtsW, require their cognate transpeptidases PBP2 and FtsI (class B penicillin binding proteins) to synthesize PG along the cell cylinder and at the septum, respectively.
Ying Li, Han Gong, Rui Zhan, Shushan Ouyang, Kyung-Tae Park, Joe Lutkenhaus, Shishen Du   +6 more
doaj   +1 more source

Essential Role for FtsL in Activation of Septal Peptidoglycan Synthesis

mBio, 2020
Spatiotemporal regulation of septal peptidoglycan (PG) synthesis is achieved by coupling assembly and activation of the synthetic enzymes (FtsWI) to the Z ring, a cytoskeletal element that is required for division in most bacteria.
Kyung-Tae Park, Shishen Du, Joe Lutkenhaus   +2 more
doaj   +1 more source

ZapA uses a two-pronged mechanism to facilitate Z ring formation in <i>Escherichia coli</i>. [PDF]

mLife
Abstract The tubulin‐like protein FtsZ assembles into the Z ring that leads to the assembly and activation of the division machinery in most bacteria. ZapA, a widely conserved protein that interacts with FtsZ, plays a pivotal role in organizing FtsZ filaments into a coherent Z ring.
Cui Y, Gong H, Yan D, Li H, Yang W, Li Y, Chen X, Lutkenhaus J, Huang SY, Yang X, Du S.   +10 more
europepmc   +2 more sources

Diversification of division mechanisms in endospore-forming bacteria revealed by analyses of peptidoglycan synthesis in Clostridioides difficile

Nature Communications, 2023
The bacterial enzymes FtsW and FtsI, encoded in the highly conserved dcw gene cluster, are considered to be universally essential for the synthesis of septal peptidoglycan (PG) during cell division.
Shailab Shrestha, Najwa Taib, Simonetta Gribaldo, Aimee Shen   +3 more
doaj   +1 more source