Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice. [PDF]
PLoS Pathogens, 2015 The identification of Mycobacterium tuberculosis genes necessary for persistence in vivo provides insight into bacterial biology as well as host defense strategies. We show that disruption of M.
Nichole Goodsmith +11 more
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Inactivation of FtsI inhibits constriction of the FtsZ cytokinetic ring and delays the assembly of FtsZ rings at potential division sites [PDF]
Proceedings of the National Academy of Sciences, 1997 A universally conserved event in cell division is the formation of a cytokinetic ring at the future site of division. In the bacterium Escherichia coli , this ring is formed by the essential cell division protein FtsZ. We have used immunofluorescence microscopy to show that FtsZ assembles early in the division cycle,
J, Pogliano +4 more
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Genome Medicine, 2020 Background Carbapenem-resistant Enterobacteriaceae are considered by WHO as “critical” priority pathogens for which novel antibiotics are urgently needed.
Rafael Patiño-Navarrete +9 more
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Comparison of the Efficacies of Oral β-Lactams in Selection of Haemophilus influenzae Transformants with Mutated ftsI Genes [PDF]
Antimicrobial Agents and Chemotherapy, 2008 ABSTRACT Horizontal transfer of the mutated ftsI gene from β-lactamase-nonproducing ampicillin-resistant (BLNAR) Haemophilus influenzae to a susceptible strain was examined in vitro under selection with nine oral β-lactams (ampicillin, amoxicillin, cefprozil, cefuroxime, cefpodoxime,
Sho, Takahata +4 more
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Domain-swapping analysis of FtsI, FtsL, and FtsQ, bitopic membrane proteins essential for cell division in Escherichia coli [PDF]
Journal of Bacteriology, 1997 FtsI, FtsL, and FtsQ are three membrane proteins required for assembly of the division septum in the bacterium Escherichia coli. Cells lacking any of these three proteins form long, aseptate filaments that eventually lyse. FtsI, FtsL, and FtsQ are not homologous but have similar overall structures: a small cytoplasmic domain, a single membrane-spanning
L M, Guzman, D S, Weiss, J, Beckwith
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Additional file 12: of Stationary phase persister formation in Escherichia coli can be suppressed by piperacillin and PBP3 inhibition [PDF]
, 2019 Figure S10. . Expression of FtsI* resulted in filamentation whereas expression of FtsI, FtsITrunc, and FtsI*Trunc did not. Cultures of MG1655 carrying pKG110-ftsI (A, left), pKG110-ftsI* (A, right), pKG110-ftsITrunc (B, left), or pKG110-ftsI*Trunc (B ...
Sandra Aedo (6874199) +2 more
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A DNA damage-induced, SOS-independent checkpoint regulates cell division in Caulobacter crescentus. [PDF]
PLoS Biology, 2014 Cells must coordinate DNA replication with cell division, especially during episodes of DNA damage. The paradigm for cell division control following DNA damage in bacteria involves the SOS response where cleavage of the transcriptional repressor LexA ...
Joshua W Modell +3 more
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Frontiers in Public Health, 2022 BackgroundThe widespread use of antimicrobials and Haemophilus influenzae type b (Hib) vaccine worldwide has altered the epidemiological patterns of invasive H. influenzae.
Yuhong Zhou +5 more
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Polymorphism in ftsI gene and ß-lactam susceptibility in Portuguese Haemophilus influenzae strains: clonal dissemination of β-lactamase-positive isolates with decreased susceptibility to amoxicillin-clavulanic acid [PDF]
, 2011 OBJECTIVES: The aim of this study was to characterize ampicillin resistance mechanisms in clinical isolates of Haemophilus influenzae from Portugal. Association between specific patterns of amino acid substitutions in penicillin-binding protein 3 (PBP3) (
Barbosa, Ana Raquel +7 more
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Crystal structure of penicillin-binding protein 3 (PBP3) from Escherichia coli. [PDF]
PLoS ONE, 2014 In Escherichia coli, penicillin-binding protein 3 (PBP3), also known as FtsI, is a central component of the divisome, catalyzing cross-linking of the cell wall peptidoglycan during cell division. PBP3 is mainly periplasmic, with a 23 residues cytoplasmic
Eric Sauvage +10 more
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