Results 61 to 70 of about 2,944 (157)

Genomic Characterization of Pan‐Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Klebsiella pneumoniae isolate KPNW showed resistance to all clinically relevant antibiotics. Upon whole genome sequencing and characterization, we detected a large number of antimicrobial resistance genes, resistance‐associated point mutations, virulence determinants, heavy metal resistance genes, and mobile genetic elements in errorits genome ...
Md. Wahid Murad, G. M. Shah Poran, Kalpana Baidya, Nazmul Ahsan   +3 more
wiley   +1 more source

Cefotaxime resistance in invasive Haemophilus influenzae isolates in Germany 2016–19: prevalence, epidemiology and relevance of PBP3 substitutions

Journal of Antimicrobial Chemotherapy, 2021
Abstract Background Haemophilus influenzae can cause invasive infections, in which cefotaxime is among the first-line antibiotics for treatment. The prevalence of cefotaxime-resistant H. influenzae in Europe is reported to be on a low level.
Sebastian, Nürnberg, Heike, Claus, Manuel, Krone, Ulrich, Vogel, Thiên-Trí, Lâm   +4 more
openaire   +2 more sources

Penicillin Binding Protein Substitutions Cooccur with Fluoroquinolone Resistance in Epidemic Lineages of Multidrug-Resistant Clostridioides difficile

mBio, 2023
Clostridioides difficile remains a key cause of healthcare-associated infection, with multidrug-resistant (MDR) lineages causing high-mortality (≥20%) outbreaks.
Kate E. Dingle, Jane Freeman, Xavier Didelot, T. Phuong Quan, David W. Eyre, Jeremy Swann, William D. Spittal, Emma V. Clark, Keith A. Jolley, A. Sarah Walker, Mark H. Wilcox, Derrick W. Crook   +11 more
doaj   +1 more source

Imipenem Resistance in Clostridium difficile Ribotype 017, Portugal

Emerging Infectious Diseases, 2018
We describe imipenem-resistant and imipenem-susceptible clinical isolates of Clostridium difficile ribotype 017 in Portugal. All ribotype 017 isolates carried an extra penicillin-binding protein gene, pbp5, and the imipenem-resistant isolates had ...
Joana Isidro, Andrea Santos, Alexandra Nunes, Vítor Borges, Catarina Silva, Luís Vieira, Aristides L. Mendes, Mónica Serrano, Adriano O. Henriques, João Paulo Gomes, Mónica Oleastro   +10 more
doaj   +1 more source

Lytic Transglycosylase Deficiency Increases Susceptibility to β‐lactam Antibiotics But Reduces Susceptibility to Vancomycin in Escherichia coli

Microbiology and Immunology, Volume 69, Issue 8, Page 407-417, August 2025.
ABSTRACT In Staphylococcus aureus, a gram‐positive pathogen, vancomycin‐resistant strains become susceptible to β‐lactam antibiotics, referred to as the “seesaw effect.” However, in gram‐negative bacteria, the phenomenon is less clear. Here, we analyzed the gene‐knockout effects of eight lytic transglycosylases (slt, mltA, mltB, mltC, mltD, mltE, mltF,
Takahiko Kimura, Kazuya Ishikawa, Ryosuke Nakagawa, Kazuyuki Furuta, Chikara Kaito   +4 more
wiley   +1 more source

Pharmacokinetic and pharmacodynamic evaluation of sulbactam‐durlobactam in a critically ill patient on continuous venovenous hemofiltration infected with carbapenem‐resistant Acinetobacter baumannii‐calcoaceticus complex

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 7, Page 396-402, July 2025.
Abstract Background Drug databases currently do not provide dosing guidance for sulbactam‐durlobactam in continuous renal replacement therapy. Herein, we present the first in vivo pharmacokinetic (PK) evaluation of sulbactam‐durlobactam during continuous venovenous hemofiltration (CVVH) in a patient with carbapenem‐resistant Acinetobacter baumannii ...
Wesley D. Kufel, Nabil Zeineddine, Aliaa Fouad, Hanna F. Roenfanz, Ryan K. Shields, Ellen G. Kline, Jameson Warner, Kathleen Hanrahan, Joseph L. Kuti   +8 more
wiley   +1 more source

Struggle To Survive: the Choir of Target Alteration, Hydrolyzing Enzyme, and Plasmid Expression as a Novel Aztreonam-Avibactam Resistance Mechanism

mSystems, 2020
Aztreonam-avibactam is a promising antimicrobial combination against multidrug-resistant organisms, such as carbapenemase-producing Enterobacterales. Resistance to aztreonam-avibactam has been found, but the resistance mechanism remains poorly studied ...
Ke Ma, Yu Feng, Alan McNally, Zhiyong Zong   +3 more
doaj   +1 more source

Selective expansion of gut antibiotic resistome and underlying pathways involved in type 1 diabetes

iMetaOmics, Volume 2, Issue 2, June 2025.
Selective expansion of gut antibiotic resistance genes (including glycopeptides, tetracyclines, macrolide‐lincosamide‐streptogramins, and beta‐lactams) was observed in type 1 diabetic rats. Interestingly, a similar expansion of gut antibiotic resistome occurred in diabetic patients.
Guozhu Ye, Yifang Duan, Haining Huang, Guoyou Chen, Minghui Li, Ricardo David Avellán‐Llaguno, Qiansheng Huang   +6 more
wiley   +1 more source

Phytochemistry, Antibacterial and Antioxidant Activities of Grewia lasiocarpa E. Mey. Ex Harv. Fungal Endophytes: A Computational and Experimental Validation Study

Chemistry &Biodiversity, Volume 22, Issue 5, May 2025.
Schematics workflow for the isolation and characterisation of endophytic fungi from grewia lasiocarpa and their biological activity. Abstract The genus Grewia are well‐known for their medicinal properties and are widely used in traditional remedies due to their rich phytochemical composition and potential health benefits.
Nneka Augustina Akwu, Yougasphree Naidoo, Moganavelli Singh, Johnson Lin, Jamiu Olaseni Aribisala, Saheed Sabiu, Makhotso Lekhooa, Adeyemi Oladapo Aremu   +7 more
wiley   +1 more source

A Review of In Silico and In Vitro Approaches in the Fight Against Carbapenem‐Resistant Enterobacterales

Journal of Clinical Laboratory Analysis, Volume 39, Issue 9, May 2025.
This review highlights computational approaches for discovering antimicrobials against carbapenem‐resistant Enterobacterales. It outlines methods like pharmacophore modeling, molecular docking, and absorption, distribution, metabolism, and excretion–toxicity (ADMET) analysis, integrated with in vitro assays, to identify and validate potential drugs ...
Muhammad Absar, Abdul Rahman Zaidah, Amer Mahmood, Sajjad Ahmad, Hasan Ejaz, Naveed Ahmed, Nik Haszroel Hysham Nik Hashim, Chan Yean Yean   +7 more
wiley   +1 more source