Results 81 to 90 of about 2,944 (157)

Localization and Single Molecule Dynamics of Bacillus subtilis Penicillin-Binding Proteins Depend on Substrate Availability and Are Affected by Stress Conditions

Cells
We have used single molecule tracking to investigate dynamics of four penicillin-binding proteins (PBPs) in Bacillus subtilis to shed light on their possible modes of action.
Lisa Stuckenschneider, Peter L. Graumann
doaj   +1 more source

Amino acid substitutions in PBP3 in Haemophilus influenzae strains, their phenotypic detection and impact on resistance to β-lactams

Journal of Antimicrobial Chemotherapy
Abstract Background Data from surveillance on antibiotic resistance have shown an increasing prevalence of non-enzymatic resistance (β-lactamase-negative ampicillin-resistant) to β-lactam antibiotics among H. influenzae strains in the Czech Republic.
Vladislav Jakubu, Marketa Cechova, Martin Musilek, Lucia Malisova, Barbora Zapletalova, Helena Zemlickova   +5 more
openaire   +2 more sources

Novel Modified Piperacillin Inhibitors of Penicillin-Binding Protein 3 (PBP3) and Their Intermolecular Interactions

Pakistan Journal of Biological Sciences
<b>Background and Objective:</b> Despite the rise of antibiotic resistance, penicillin and the broader group of β-lactams have continued to be the most crucial class of antibiotics. Penicillin-Binding Protein 3 (PBP3) in <i>Pseudomonas aeruginosa</i> is the specific molecule that β-lactam-based medicines target. The objective is
openaire   +2 more sources

A four-amino-acid YRIN insertion in ftsI reduced ceftiofur susceptibility in a canine Escherichia coli isolate

One Health Advances
Ceftiofur resistance in canine clinical Escherichia coli is usually associated with extended-spectrum β-lactamases (ESBLs) or AmpC β-lactamases. However, some isolates display elevated ceftiofur minimum inhibitory concentrations (MICs) without carrying ...
Xukun Dang, Zeshi Chen, Rina Bai, Junyao Jiang, Weishuai Zhai, Shizhen Ma, Lu Liu, Dejun Liu, Zhaofei Xia, Zhangqi Shen, Yang Wang, Siyu Chen   +11 more
doaj   +1 more source

Additional file 1: of A novel PBP3 substitution in Haemophilus influenzae confers reduced aminopenicillin susceptibility

, 2018
Growth curves demonstrate that the clinical strain NTHi93–57,485 has a slower growth rate than the rPBP3 WT strain NTHi3655 and the corresponding mutant NTHi3655-PBP3Y528H. Mean values from 3 separate experiments are shown. Error bars represent standard error of the mean (SEM).
Thegerström, John, Matuschek, Erika, Yu-Ching Su, Riesbeck, Kristian, Resman, Fredrik   +4 more
openaire   +1 more source

Next generation antibiotic combinations to combat pan-drug resistant Klebsiella pneumoniae

Scientific Reports
Antimicrobial resistance has emerged as one of the leading public health threats of the twenty-first century. Gram-negative pathogens have been a major contributor to the declining efficacy of antibiotics through both acquired resistance and tolerance ...
Jan Naseer Kaur, Navaldeep Singh, Nicholas M. Smith, Jack F. Klem, Raymond Cha, Yinzhi Lang, Liang Chen, Barry Kreiswirth, Patricia N. Holden, Jürgen B. Bulitta, Brian T. Tsuji   +10 more
doaj   +1 more source

Discovery of amino acid substitutions in penicillin-binding proteins associated with adaptation to D-Ala-D-Lac in vancomycin-resistant Enterococcus faecalis

Frontiers in Cellular and Infection Microbiology
The bacterial cell wall, essential for structural integrity, is synthesized with penicillin-binding proteins (PBPs). Vancomycin-resistant enterococci (VRE) evades vancomycin by replacing D-Ala-D-Ala in their cell wall precursors with D-Ala-D-Lac ...
Nese Caglayan, Banu Sancak, Zeynep Kanlidere, Tanil Kocagoz, Tanil Kocagoz   +4 more
doaj   +1 more source

POTENTIAL OF THE Spatholobus littoralis AS AN ANTIBACTERIAL AND PREDICTION OF THE MECHANISM OF ACTIVITY AGAINST PBP3 RECEPTOR MODEL OF Staphylococcus aureus

RASAYAN Journal of Chemistry
Spatholobus littoralis is a typical plant of Kalimantan, which is ethnopharmacologically used in herbal medicine. The purpose of this study was to test the activity of S. littoralis root extract against Staphylococcus aureus bacteria in vitro and to predict the mechanism of its interaction with Staphylococcus aureus penicillin-binding protein-3 (PBP-3)
null S. Atun, null C. Budimarwanti, null S. Suwardi, null S. Nurjanah, null R. Az-Zahra, null A. C. B. Garinda, null R. Damara, null E. Octaviani, null A. Sangal   +8 more
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Exploring Oxygenated Sesquiterpenes from Merauke Agarwood as PBP1a and PBP3 Inhibitors in Acinetobacter baumanii: An In-Silico Approach

Jurnal Penelitian Pendidikan IPA
Acinetobacter baumannii is a multidrug-resistant pathogen causing severe nosocomial infections, primarily associated with alterations in penicillin-binding proteins (PBPs) that reduce the effectiveness of β- lactam antibiotics. Despite increasing interest in plant-derived bioactive compounds, the potential of oxygenated sesquiterpenes from Aquilaria ...
Prasetya, Yulianto Ade, Saputro, Triono Bagus, Negara, Yohanes Ardian Kapri, Luqman, Arif   +3 more
openaire   +1 more source

Antioxidant, Antibacterial Activity, In Silico Molecular Docking, and ADME-Toxicity Study of Lactone from Rhizome of Angiopteris helferiana

Journal of Chemistry
Objective. The red rhizome of Angiopteris helferiana has been used widely to treat muscle fatigue, bone pain, and skin infection in Nepal. However, scientific evidence for its bioactive compounds and their bioactivities was lacking till January, 2024 ...
Ram Kishor Yadav, Priyanka Shrestha, Kalpana Timilsina, Akriti Dhakal, Sandesh Poudel, Sindhu K. C., Prabhat Kumar Jha, Susheel Paneru, Rekha Bhandari, Khem Raj Joshi   +9 more
doaj   +1 more source