Results 81 to 90 of about 5,166 (218)

Imipenem heteroresistance in nontypeable Haemophilus influenzae is linked to a combination of altered PBP3, slow drug influx and direct efflux regulation [PDF]

Clinical Microbiology and Infection, 2017
To investigate the potential roles of PBPs, efflux pumps and slow drug influx for imipenem heteroresistance in nontypeable Haemophilus influenzae (NTHi).Fifty-nine NTHi clinical isolates examined in this study were collected at Geneva University Hospitals between 2009 and 2014. Alterations in PBPs were investigated by gene sequencing.
Cherkaoui, Abdessalam, Diene, S M, Renzoni, Adriana Maria, Emonet, Stéphane, Renzi, Gesuele, Francois, Patrice, Schrenzel, Jacques   +6 more
openaire   +4 more sources

SanA Plays a Role in Peptidoglycan Integrity in Escherichia coli

Molecular Microbiology, Volume 125, Issue 4, Page 343-357, April 2026.
SanA is a novel regulator of peptidoglycan synthesis, potentially through functional interplay with PBP1B‐dependent pathways. ABSTRACT Peptidoglycan synthesis and degradation are both essential for bacterial growth, and damaged peptidoglycan must be continuously repaired. In Escherichia coli, peptidoglycan required for cell elongation is synthesized by
Honoka Yamaguchi, Risa Ago, Yuhei O. Tahara, Mari Inoue, Hironori Niki, Makoto Miyata, Daisuke Shiomi   +6 more
wiley   +1 more source

Bismuth Bicycles

Journal of Peptide Science, Volume 32, Issue 3, March 2026.
Discovery, evolution and potential future applications of bismuth bicycle molecules—a novel class of therapeutics with unique properties. ABSTRACT Bicyclic peptides are emerging as next generation therapeutics by combining the affinity and specificity of antibodies with the synthetic convenience of small molecules.
Saan Voss, Amin Sagar, Arnaud Tiberghien, Richard J. L. Hughes, Liuhong Chen, Inmaculada Rioja, Mark Frigerio, Michael J. Skynner, David R. Spring   +8 more
wiley   +1 more source

In vitro activity of cefepime/zidebactam (WCK 5222) against Gram-negative bacteria [PDF]

, 2017
Background: Diazabicyclooctanes (DBOs) inhibit class A, class C and some class D β-lactamases. A few also bind PBP2, conferring direct antibacterial activity and a β-lactamase-independent ‘enhancer' effect, potentiating β-lactams targeting PBP3.
Livermore, David M, Mushtaq, Shazad, Vickers, Anna, Warner, Marina, Woodford, Neil   +4 more
core   +1 more source

Revisiting mutational resistance to ampicillin and cefotaxime in Haemophilus influenzae

Genome Medicine
Background Haemophilus influenzae is an opportunistic bacterial pathogen that can cause severe respiratory tract and invasive infections. The emergence of β-lactamase-negative ampicillin-resistant (BLNAR) strains and unclear correlations between ...
Margo Diricks, Sabine Petersen, Lennart Bartels, Thiên-Trí Lâm, Heike Claus, Maria Paula Bajanca-Lavado, Susanne Hauswaldt, Ricardo Stolze, Omar Jiménez Vázquez, Christian Utpatel, Stefan Niemann, Jan Rupp, Inken Wohlers, Matthias Merker   +13 more
doaj   +1 more source

A Hunt for the Resistance of Haemophilus influnezae to Beta-Lactams

Antibiotics
Infections due to Haemophilus influnezae require prompt treatment using beta-lactam antibiotics. We used a collection of 81 isolates obtained between 1940 and 2001 from several countries.
Mélanie Denizon, Eva Hong, Aude Terrade, Muhamed-Kheir Taha, Ala-Eddine Deghmane   +4 more
doaj   +1 more source

A Review of β‐Lactamase Inhibitors in Clinical Use and Development: Mechanisms, Spectrum, and Therapeutic Applications

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
β‐Lactam antibiotics have long served as a cornerstone for treating bacterial infections. However, their widespread and often indiscriminate use has fueled the emergence of multidrug‐resistant Gram‐negative pathogens, primarily through the production and dissemination of β‐lactamase enzymes.
Mohammad Javad Roustaye Gourabi, Anita Nikoo, Bita Khanbabaei, Masoud Kargar, Amirhossein Fayyazi, Seyyed Mohammad Javad Mousavi, Amirhossein Aghdaee, Ali Hashemi, Javad Yasbolaghi Sharahi, Swaran J. S. Flora   +9 more
wiley   +1 more source

Cefotaxime resistance in invasive Haemophilus influenzae isolates in Germany 2016–19: prevalence, epidemiology and relevance of PBP3 substitutions

Journal of Antimicrobial Chemotherapy, 2021
Abstract Background Haemophilus influenzae can cause invasive infections, in which cefotaxime is among the first-line antibiotics for treatment. The prevalence of cefotaxime-resistant H. influenzae in Europe is reported to be on a low level.
Sebastian, Nürnberg, Heike, Claus, Manuel, Krone, Ulrich, Vogel, Thiên-Trí, Lâm   +4 more
openaire   +2 more sources

Integrated Bioprospection of Phenolics as Potent Modulators of Acinetobacter baumannii Penicillin‐Binding Protein 1A

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Diseases caused by carbapenem‐resistant Acinetobacter baumannii can lead to death within 48 h of hospitalization, with an overall mortality rate of 68%. The reduced affinity of carbapenem and other β‐lactams for penicillin‐binding proteins 1A (PBP1A), a critical protein, is a key resistance mechanism in A. baumannii.
Oladunni Ayodele, Saheed Sabiu, Sohini Basu Roy   +2 more
wiley   +1 more source

The role of peptidoglycan in chlamydial cell division: towards resolving the chlamydial anomaly [PDF]

, 2017
Chlamydiales are obligate intracellular bacteria including some important pathogens causing trachoma, genital tract infections and pneumonia, among others. They share an atypical division mechanism, which is independent of an FtsZ homologue.
Gerdes, Kenn, Greub, Gilbert, Jacquier, Nicolas, Viollier, Patrick H.   +3 more
core