Results 101 to 110 of about 5,166 (218)

Clinical and molecular epidemiology of haemophilus influenzae causing invasive disease in adult patients [PDF]

, 2015
Objectives The epidemiology of invasive Haemophilus influenzae (Hi) has changed since the introduction of the Hi type b (Hib) vaccine. The aim of this study was to analyze the clinical and molecular epidemiology of Hi invasive disease in adults.
Ardanuy Tisaire, María Carmen, Calatayud, Laura, Grau, Immaculada, Liñares Louzao, Josefina, Martí Martí, Sara, Pallarés Giner, Roman, Puig Pitarch, Carmen, Tubau, Fe   +7 more
core   +1 more source

Lytic Transglycosylase Deficiency Increases Susceptibility to β‐lactam Antibiotics But Reduces Susceptibility to Vancomycin in Escherichia coli

Microbiology and Immunology, Volume 69, Issue 8, Page 407-417, August 2025.
ABSTRACT In Staphylococcus aureus, a gram‐positive pathogen, vancomycin‐resistant strains become susceptible to β‐lactam antibiotics, referred to as the “seesaw effect.” However, in gram‐negative bacteria, the phenomenon is less clear. Here, we analyzed the gene‐knockout effects of eight lytic transglycosylases (slt, mltA, mltB, mltC, mltD, mltE, mltF,
Takahiko Kimura, Kazuya Ishikawa, Ryosuke Nakagawa, Kazuyuki Furuta, Chikara Kaito   +4 more
wiley   +1 more source

Loss of PopZ At activity in Agrobacterium tumefaciens by Deletion or Depletion Leads to Multiple Growth Poles, Minicells, and Growth Defects. [PDF]

, 2017
Agrobacterium tumefaciens grows by addition of peptidoglycan (PG) at one pole of the bacterium. During the cell cycle, the cell needs to maintain two different developmental programs, one at the growth pole and another at the inert old pole.
Bonnie Bassler, John Zupan, Patricia C. Zambryski, Romain Grangeon, Yeonji Jeon   +4 more
core   +2 more sources

Struggle To Survive: the Choir of Target Alteration, Hydrolyzing Enzyme, and Plasmid Expression as a Novel Aztreonam-Avibactam Resistance Mechanism

mSystems, 2020
Aztreonam-avibactam is a promising antimicrobial combination against multidrug-resistant organisms, such as carbapenemase-producing Enterobacterales. Resistance to aztreonam-avibactam has been found, but the resistance mechanism remains poorly studied ...
Ke Ma, Yu Feng, Alan McNally, Zhiyong Zong   +3 more
doaj   +1 more source

Pharmacokinetic and pharmacodynamic evaluation of sulbactam‐durlobactam in a critically ill patient on continuous venovenous hemofiltration infected with carbapenem‐resistant Acinetobacter baumannii‐calcoaceticus complex

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 7, Page 396-402, July 2025.
Abstract Background Drug databases currently do not provide dosing guidance for sulbactam‐durlobactam in continuous renal replacement therapy. Herein, we present the first in vivo pharmacokinetic (PK) evaluation of sulbactam‐durlobactam during continuous venovenous hemofiltration (CVVH) in a patient with carbapenem‐resistant Acinetobacter baumannii ...
Wesley D. Kufel, Nabil Zeineddine, Aliaa Fouad, Hanna F. Roenfanz, Ryan K. Shields, Ellen G. Kline, Jameson Warner, Kathleen Hanrahan, Joseph L. Kuti   +8 more
wiley   +1 more source

Can fosfomycin be an alternative therapy for infections caused byE. coliharbouring dual resistance: NDM and four-amino acid insertion in PBP3? [PDF]

, 2023
Yamuna Devi Bakthavatchalam, Abirami Shankar, Yuvasri Manokaran, Kāmini Walia, Balaji Veeraraghavan   +4 more
openalex   +1 more source

Selective expansion of gut antibiotic resistome and underlying pathways involved in type 1 diabetes

iMetaOmics, Volume 2, Issue 2, June 2025.
Selective expansion of gut antibiotic resistance genes (including glycopeptides, tetracyclines, macrolide‐lincosamide‐streptogramins, and beta‐lactams) was observed in type 1 diabetic rats. Interestingly, a similar expansion of gut antibiotic resistome occurred in diabetic patients.
Guozhu Ye, Yifang Duan, Haining Huang, Guoyou Chen, Minghui Li, Ricardo David Avellán‐Llaguno, Qiansheng Huang   +6 more
wiley   +1 more source

A DNA Damage-Induced, SOS-Independent Checkpoint Regulates Cell Division in Caulobacter crescentus [PDF]

, 2014
Cells must coordinate DNA replication with cell division, especially during episodes of DNA damage. The paradigm for cell division control following DNA damage in bacteria involves the SOS response where cleavage of the transcriptional repressor LexA ...
Kambara, Tracy K., Laub, Michael T., Modell, Joshua W., Perchuk, Barrett   +3 more
core   +3 more sources

Phytochemistry, Antibacterial and Antioxidant Activities of Grewia lasiocarpa E. Mey. Ex Harv. Fungal Endophytes: A Computational and Experimental Validation Study

Chemistry &Biodiversity, Volume 22, Issue 5, May 2025.
Schematics workflow for the isolation and characterisation of endophytic fungi from grewia lasiocarpa and their biological activity. Abstract The genus Grewia are well‐known for their medicinal properties and are widely used in traditional remedies due to their rich phytochemical composition and potential health benefits.
Nneka Augustina Akwu, Yougasphree Naidoo, Moganavelli Singh, Johnson Lin, Jamiu Olaseni Aribisala, Saheed Sabiu, Makhotso Lekhooa, Adeyemi Oladapo Aremu   +7 more
wiley   +1 more source

A Review of In Silico and In Vitro Approaches in the Fight Against Carbapenem‐Resistant Enterobacterales

Journal of Clinical Laboratory Analysis, Volume 39, Issue 9, May 2025.
This review highlights computational approaches for discovering antimicrobials against carbapenem‐resistant Enterobacterales. It outlines methods like pharmacophore modeling, molecular docking, and absorption, distribution, metabolism, and excretion–toxicity (ADMET) analysis, integrated with in vitro assays, to identify and validate potential drugs ...
Muhammad Absar, Abdul Rahman Zaidah, Amer Mahmood, Sajjad Ahmad, Hasan Ejaz, Naveed Ahmed, Nik Haszroel Hysham Nik Hashim, Chan Yean Yean   +7 more
wiley   +1 more source