Results 121 to 130 of about 5,166 (218)
International Journal of Infectious DiseasesObjectives: To evaluate susceptibilities of novel antibiotics against imipenem-non-susceptible (INS) Escherichia coli (INS-EC), Klebsiella pneumoniae (INS-KP), Acinetobacter baumannii (INS-AB), Pseudomonas aeruginosa (INS-PA) in Taiwan, and the potential
Yan-Ru Wang +9 more
doaj +1 more source
Journal of the Science of Food and Agriculture, Volume 105, Issue 3, Page 1711-1736, February 2025.Abstract BACKGROUND Yellow mealworm (Tenebrio molitor) larvae are increasingly recognized as a potential source of bioactive peptides due to their high protein content. Antimicrobial peptides from sustainable sources are a research topic of interest. This study aims to characterize the peptidome of T.
Teresa Gonzalez‐de la Rosa +4 more
wiley +1 more source
In vivo functional and molecular characterization of the Penicillin-Binding Protein 4 (DacB) of Pseudomonas aeruginosa [PDF]
, 2016 Background: Community and nosocomial infections by Pseudomonas aeruginosa still create a major therapeutic challenge. The resistance of this opportunist pathogen to β-lactam antibiotics is determined mainly by production of the inactivating enzyme AmpC ...
Aguilera Rossi, Cristian Gustavo +2 more
core +1 more source
New insights into the regulatory pathways associated with the activation of the stringent response in bacterial resistance to the PBP2-targeted antibiotics, mecillinam and OP0595/RG6080 [PDF]
, 2016 Objectives: The diazabicyclooctane β-lactamase inhibitor OP0595 (RG6080) also acts as an antibiotic, targeting PBP2 in Enterobacteriaceae, but this activity is vulnerable to mutational resistance.
D. M. Livermore +10 more
core +1 more source
Heterologous viral expression systems in fosmid vectors increase the functional analysis potential of metagenomic libraries [PDF]
, 2013 The extraordinary potential of metagenomic functional analyses to identify activities of interest present in uncultured microorganisms has been limited by reduced gene expression in surrogate hosts. We have developed vectors and specialized E.
Limón Mortés, María Cristina +3 more
core +1 more source
Pakistan Journal of Biological Sciences<b>Background and Objective:</b> Despite the rise of antibiotic resistance, penicillin and the broader group of β-lactams have continued to be the most crucial class of antibiotics. Penicillin-Binding Protein 3 (PBP3) in <i>Pseudomonas aeruginosa</i> is the specific molecule that β-lactam-based medicines target. The objective is
openaire +2 more sources
, 2018 Growth curves demonstrate that the clinical strain NTHi93–57,485 has a slower growth rate than the rPBP3 WT strain NTHi3655 and the corresponding mutant NTHi3655-PBP3Y528H. Mean values from 3 separate experiments are shown. Error bars represent standard error of the mean (SEM).
Thegerström, John +4 more
openaire +1 more source
Natural methicillin resistance in comparison with that selected by in-vitro drug exposure in Staphylococcus aureus [PDF]
, 2017 Methicillin resistant staphylococci selected during serial passage in increasing concentrations of methicillin were compared with an isogenic methicillin resistant strain carrying the methicillin resistance determinant (mec) found in clinical isolates of
Berger-Bächi, B. +2 more
core
Early Insights into the Interactions of Different β-Lactam Antibiotics and β-Lactamase Inhibitors against Soluble Forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3 [PDF]
, 2012 Krisztina M. Papp‐Wallace +14 more
openalex +1 more source
Frontiers in Cellular and Infection Microbiology, 2014 For intracellular Chlamydiaceae, there is no need to withstand osmotic challenges, and a functional cell wall has not been detected in these pathogens so far. Nevertheless, penicillin inhibits cell division in Chlamydiaceae resulting in enlarged aberrant
Stefania eDe Benedetti +7 more
doaj +1 more source