Results 141 to 150 of about 2,944 (157)

Screening of natural products targeting PBP3 and their synergistic effects with antibiotics in inhibiting Streptococcus pneumoniae

Food Bioscience
Zhuodi Wu, Yimeng Chen, Yu Cui, Doudou Yang, Guanjie Zhao, Qian Li, Dandan Zhang, Yinku Liang   +7 more
exaly   +2 more sources

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Reduced susceptibility to aztreonam-avibactam conferred by acquired AmpC-type β-lactamases in PBP3-modified Escherichia coli

European Journal of Clinical Microbiology and Infectious Diseases
Carbapenemase-producing Enterobacterales are a growing threat, and very few therapeutic options remain active against those multidrug resistant bacteria. Aztreonam is the molecule of choice against metallo-beta-lactamases (MBL) producers since it is not hydrolyzed by those enzymes, but the co-production of acquired plasmidic cephalosporinases or ...
Nicolas Helsens, Mustafa Sadek, Christophe Le Terrier   +2 more
exaly   +4 more sources

Crystal Structures of Penicillin-Binding Protein 3 (PBP3) from Methicillin-Resistant Staphylococcus aureus in the Apo and Cefotaxime‐Bound Forms

Journal of Molecular Biology, 2012
Staphylococcus aureus is a widespread Gram-positive opportunistic pathogen, and a methicillin-resistant form (MRSA) is particularly difficult to treat clinically. We have solved two crystal structures of penicillin-binding protein (PBP) 3 (PBP3) from MRSA, the apo form and a complex with the β-lactam antibiotic cefotaxime, and used electrospray mass ...
Hisashi, Yoshida, Fumihiro, Kawai, Eiji, Obayashi, Satoko, Akashi, David I, Roper, Jeremy R H, Tame, Sam-Yong, Park   +6 more
openaire   +2 more sources

[Isolation of beta-lactamase non-producing ampicillin-resistant Haemophilus influenzae (BLNAR) and analysis of its PBP3 gene].

Rinsho byori. The Japanese journal of clinical pathology, 2008
We analyzed the incidence of beta-lactamase non-producing ampicillin-resistance (BLNAR) Haemophilus influenzae in Showa University Hospital from June 2004 to March 2005. The ratio of BLNAR in total H. influenzae isolates was 44.5%. BLNAR accounted for 89.6% of the ampicillin non-susceptible strains displaying a minimal inhibitory concentration(MIC) of ...
Fumihiro, Yamaguchi, Takaaki, Kuroda, Tsutomu, Yasuhara, Rika, Wakuta, Kunihiko, Fukuchi, Kunihide, Gomi   +5 more
openaire   +1 more source

Escherichia coli strains possessing a four amino acid YRIN insertion in PBP3 identified as part of the SIDERO-WT-2014 surveillance study

JAC-Antimicrobial Resistance, 2020
Takafumi Sato, Akinobu Itô, Shuhei Matsumoto   +2 more
exaly  

Novel and Improved Crystal Structures of H. influenzae, E. coli and P. aeruginosa Penicillin-Binding Protein 3 (PBP3) and N. gonorrhoeae PBP2: Toward a Better Understanding of β-Lactam Target-Mediated Resistance

Journal of Molecular Biology, 2019
Lizbé Koekemoer, Hector Newman, Christopher G Dowson   +2 more
exaly  

Multidrug-resistant Escherichia coli mutants selected with diazepam or lomefloxacin overexpressing soxS, sdiA, acrAB, TolC and PBP3

2019
S52
Tavio, M. M., Aquili, V., Fabrega, A., Gonzalez-Lama, Z., Poveda, J. B., Vila, J.   +5 more
openaire   +1 more source

Localization of PBP3 in Caulobacter crescentus is highly dynamic and largely relies on its functional transpeptidase domain

Molecular Microbiology, 2008
Richa Priyadarshini, Christine Jacobs-Wagner   +1 more
exaly  

High prevalence of Escherichia coli clinical isolates in India harbouring four amino acid inserts in PBP3 adversely impacting activity of aztreonam/avibactam

Journal of Antimicrobial Chemotherapy, 2020
Hariharan Periasamy, Rahul Shrivastava, Sachin Bhagwat   +2 more
exaly  

Contribution of PBP3 Substitutions and TEM-1, TEM-15, and ROB-1 Beta-Lactamases to Cefotaxime Resistance in Haemophilus influenzae and Haemophilus parainfluenzae

Microbial Drug Resistance, 2016
Niels Nørskov-Lauritsen
exaly