Results 111 to 120 of about 5,166 (218)

Beta‐Lactam Antibiotics Promote Extracellular Vesicle Production of Staphylococcus aureus Through ROS‐Mediated Lipid Metabolic Reprogramming

Journal of Extracellular Vesicles, Volume 14, Issue 5, May 2025.
ABSTRACT Bacterial extracellular vesicles (EVs) are natural reservoirs of biological active substances. They exhibit promising application in developing bioproducts such as vaccine, drug‐delivery system and anticancer agent. However, the low yield of naturally secreted EVs during bacterial growth is a bottleneck factor that restricts EV applications ...
Xiaonan Huang, Zhen Hu, Weilong Shang, Juan Chen, Qiwen Hu, Yumin Zhou, Ruolan Ding, Jing Yin, Mengyang Li, He Liu, Jianxiong Dou, Huagang Peng, Yifan Rao, Lu Liu, Yuting Wang, Li Tan, Yuhua Yang, Jianghong Wu, Chuan Xiao, Yi Yang, Xiancai Rao   +20 more
wiley   +1 more source

Design, Synthesis, and Antibacterial Evaluation of Pyrazole Pyrimidine Hybrids: Integrative In Vitro and In Silico Studies

ChemistrySelect, Volume 10, Issue 17, May 5, 2025.
This study synthesizes novel pyrimidine–pyrazole hybrids and evaluates their antimicrobial activity against bacterial pathogens by targeting penicillin‐binding protein 3 (PBP3). Several compounds show significant activity against E. faecium. Docking studies reveal strong binding with HMG‐CoA synthase, while in silico pharmacokinetic predictions ...
Suresh Choppadandi, Divya Vemula, Nagaraju Kerru, Vasundhra Bhandari, Chilukoti Srilakshmi   +4 more
wiley   +1 more source

Identification of a New Family of Enzymes with Potential \u3cem\u3eO\u3c/em\u3e-acetylpeptidoglycan esterase activity in both Gram-positive and Gram-negative bacteria [PDF]

, 2005
Background: The metabolism of the rigid bacterial cell wall heteropolymer peptidoglycan is a dynamic process requiring continuous biosynthesis and maintenance involving the coordination of both lytic and synthetic enzymes.
Clarke, Anthony J., Pfeffer, John M., Weadge, Joel T.   +2 more
core   +1 more source

Penicillin-binding Proteins (PBP) and Lmo0441 (a PBP-like protein) play a role in Beta-lactam sensitivity of Listeria monocytogenes

Gut Pathogens, 2009
While seven penicillin-binding proteins (PBPs) or PBP-like proteins have been identified either by radiolabelled penicillin binding studies or genomic analysis, only PBP3 has been considered of interest for Beta-lactams activity against Listeria ...
Van de Velde Sébastien, Carryn Stéphane, Van Bambeke Françoise, Hill Colin, Tulkens Paul M, Sleator Roy D   +5 more
doaj   +1 more source

Non‐Membrane Active Peptide Resensitizes MRSA to β‐Lactam Antibiotics and Inhibits S. aureus Virulence

Advanced Science, Volume 12, Issue 15, April 17, 2025.
This work identifies a potent, non‐membrane active, and non‐toxic AMP termed GN1, which substantially resensitizes MRSA to multiple β‐lactam antibiotics at low concentrations. GN1 functions by suppressing MRSA‐associated resistance determinants, including penicillin‐binding protein 2a (PBP2a) and β‐lactamase.
Jingru Shi, Chen Chen, Pan Kong, Feiyu Yu, Qingyan Lv, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Developmental transcriptome of resting cell formation in Mycobacterium smegmatis [PDF]

, 2016
Functional classification of gene numbers up- and down-regulated during shock starvation in PBS.
Hans-Joachim Mollenkopf, Jade C. S. Chung, Martin Gengenbacher, Mu-Lu Wu, Stefan H. E. Kaufmann, Swaine Lin Chen, Thomas Dick   +6 more
core   +3 more sources

Publisher Correction: Z-ring membrane anchors associate with cell wall synthases to initiate bacterial cell division

Nature Communications, 2019
The original version of this Article contained errors in Figures 1 and 3. In Fig. 1b, the label ‘IP-PBP3’ above the second of the three blots incorrectly read ‘IP-PBP1B’. In Fig.
Manuel Pazos, Katharina Peters, Mercedes Casanova, Pilar Palacios, Michael VanNieuwenhze, Eefjan Breukink, Miguel Vicente, Waldemar Vollmer   +7 more
doaj   +1 more source

Spotlight commentary: Treatment of multidrug‐resistant Gram‐negative infections in the era of growing antimicrobial resistance

British Journal of Clinical Pharmacology, Volume 91, Issue 9, Page 2485-2489, September 2025.
Luka Bielen, Andro Vujević, Luka Csenar
wiley   +1 more source

Occurrence and spread of carbapenemase‐producing Enterobacterales (CPE) in the food chain in the EU/EFTA. Part 1: 2025 update

EFSA Journal, Volume 23, Issue 4, April 2025.
Abstract Carbapenemase‐producing Enterobacterales (CPE) have been reported in the food chain in 14 out of 30 EU/EFTA countries. Commonly reported genes are blaVIM‐1, blaOXA‐48 and blaOXA‐181, followed by blaNDM‐5 and blaIMI‐1. Escherichia coli, target of most of the studies, Enterobacter cloacae complex, Klebsiella pneumoniae complex and Salmonella ...
EFSA BIOHAZ Panel (EFSA Panel on Biological Hazards), Ana Allende, Avelino Álvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Lieve Herman, Liesbeth Jacxsens, Lapo Mughini‐Gras, Maarten Nauta, Jakob Ottoson, Fernando Pérez‐Rodríguez, Panagiotis Skandamis, Elisabetta Suffredini, Hector Argüello, Johan Bengtsson‐Palme, Alessandra Carattoli, Anke Kohlenberg, Dominique L. Monnet, Laurent Poirel, Beatriz Guerra, Raquel García‐Fierro, Ernesto Liébana, Sonagnon Martin Goudjihounde, Núria Ferrer‐Bustins, Hanne Rabbås, Luisa Peixe   +28 more
wiley   +1 more source

Targeting antibiotic resistance [PDF]

, 2016
Finding strategies against the development of antibiotic resistance is a major global challenge for the life sciences community and for public health.
Chellat, Mathieu F., Raguž, Luka, Riedl, Rainer   +2 more
core   +1 more source