Results 91 to 100 of about 835,846 (358)

Temporal shifts in the collective dermatologic microbiome of military trainees

Clinical, Cosmetic and Investigational Dermatology, 2019
Thomas F Gibbons,1 Jody C Noe,1 Andrew T Patterson,2 Brittany L Lenz,2 Thomas M Beachkofsky3159th Medical Wing Science and Technology, Clinical Investigations and Research Support, San Antonio, TX, USA; 2Department of Dermatology, 59th Medical Wing, San ...
Gibbons TF, Noe JC, Patterson AT, Lenz BL, Beachkofsky TM   +4 more
doaj  

Delabelling beta-lactam allergy

Frontiers in Pharmacology
Background: Hypersensitivity to beta-lactam (BL) antibiotics is one of the most frequent reported drug allergies. In our population, it is common to find labels of BL allergy in electronic medical records (EMRs) that have not been assessed. The objective
Gustavo-Jorge Molina-Molina, Diana Rocío Garnica Velandia, Diana Rocío Garnica Velandia, Blanca Andrés-López, Carolina Perales, Laura Marin-Asensio, Yanina Jurgens, Olga Esteso, Carolina Escobar, Xavier Vidal, Xavier Vidal, Lourdes Vendrell, Lourdes Vendrell, Lourdes Vendrell, Laura Gómez-Ganda, Dolores Rodríguez, Eva Montané, Eva Montané, Victoria Cardona, Victoria Cardona, Antònia Agustí, Antònia Agustí   +21 more
doaj   +1 more source

Penicillin Therapy in Children with Acute Rheumatic Fever: Side Effects, Malpractice and Anaphylactic Reactions

Güncel Pediatri, 2015
Acute rheumatic fever (ARF) is more common in developing countries. ARF is a systemic disorder, which develops in children following group A streptococcal (GAS) pharyngitis. Rheumatic valvular disease is caused by autoimmune responses. Penicillin is used
Murat Çiftel, Ayşe Süleyman, Halil Ertuğ   +2 more
doaj   +1 more source

Penicillin-binding proteins and beta-lactam resistance.

FEMS Microbiology Reviews, 2008
A number of ways and means have evolved to provide resistance to eubacteria challenged by beta-lactams. This review is focused on pathogens that resist by expressing low-affinity targets for these antibiotics, the penicillin-binding proteins (PBPs). Even
A. Zapun, C. Contreras-Martel, T. Vernet
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

A hope for ineffective antibiotics to return to treatment: investigating the anti-biofilm potential of melittin alone and in combination with penicillin and oxacillin against multidrug resistant-MRSA and -VRSA

Frontiers in Microbiology
BackgroundThe emergence and rapid spread of multi-drug resistant (MDR) bacterial strains, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant S.
Saba Jalalifar, Saba Jalalifar, Shabnam Razavi, Shabnam Razavi, Rasoul Mirzaei, Gholamreza Irajian, Gholamreza Irajian, Kamran Pooshang Bagheri   +7 more
doaj   +1 more source

Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus

Journal of Bacteriology, 1984
Methicillin resistance in Staphylococcus aureus has been associated with alterations in the penicillin-binding proteins (PBPs). An intriguing property of all methicillin-resistant staphylococci is the dependence of resistance on the pH value of the ...
B. Hartman, A. Tomasz
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Multimodular Penicillin-Binding Proteins: An Enigmatic Family of Orthologs and Paralogs

Microbiology and Molecular Biology Reviews, 1998
SUMMARY The monofunctional penicillin-binding dd-peptidases and penicillin-hydrolyzing serine β-lactamases diverged from a common ancestor by the acquisition of structural changes in the polypeptide chain while retaining the same folding, three-motif ...
C. Goffin, J. Ghuysen
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source