Results 71 to 80 of about 804,907 (316)

Reprogramming Hansenula polymorpha for penicillin production: expression of the Penicillium chrysogenum pcl gene [PDF]

, 2007
We aim to introduce the penicillin biosynthetic pathway into the methylotrophic yeast Hansenula polymorpha. To allow simultaneous expression of the multiple genes of the penicillin biosynthetic pathway, additional markers were required.
Ida J. van der Klei, Loknath Gidijala, Kiel, Jan A. K. W., Gidijala, Loknath, Klei, Ida J. van der,, van der Klei, Ida J., Jan A.K.W. Kiel, Veenhuis, Marten,, Gidijala, Loknath,, Kiel, Jan A.K.W.,, Marten Veenhuis, Veenhuis, Marten, van der Klei, Ida J.; id_orcid   +12 more
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Microwave-assisted synthesis and development of novel penicillinoate@copper metal-organic frameworks as a potent antibacterial agent

Frontiers in Chemistry
Recently, nanoscience, especially metal–organic frameworks (MOFs), has been used to increase the effectiveness and properties of drugs. In this study, by using microwave irradiation; penicillin, which is a known antibiotic; and copper metal–organic ...
Adnan Hashim Abdulkadhim, Suhair Mohammad Husein Kamona, Haider Falih Shamikh Al-Saedi, Anmar Ghanim Taki, Abdul-Hameed. M. Hamoody, Sarah A. Hamood, Safia Obaidur Rab, Ahmed Ali Amir, Ashwaq Talib Kareem, Ahmed Alawadi, Ahmed Alawadi, Ahmed Alawadi, Ali Ihsan   +12 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Metal complexes of penicillin and cephalosporin antibiotics

, 1975
Includes bibliographical references.The interaction between metal-ions and the penicillin and cephalosporin antibiotics have been studied in an attempt to determine both the site and mechanism of this interaction.
Jackson, Graham Ellis
core  

Effect of Gamma-Rays on the Growth and Penicillin Production of Penicillium chrysogenum

, 2019
This study aimed to investigate the effects of different doses (25, 50, 75, 100, 125, 150, 200, 250, 500, 1000 and 2000 Gy) of gamma radiation on spore germination in Penicillium chrysogenum and on the production and efficacy of penicillin in this ...
Nasreldin Elhadi, Hosam El-Sayyad, Mohammed M. Aljeldah, Ali A. Rabaan   +3 more
core   +1 more source

Effects of EDP-420 on penicillin-resistant and quinolone- and penicillin-resistant pneumococci in the rabbit meningitis model [PDF]

, 2008
OBJECTIVES: To test the efficacy of EDP-420, a new ketolide, in experimental pneumococcal meningitis and to determine its penetration into the CSF. METHODS: The experimental rabbit model was used in this study and EDP-420 was tested against a penicillin ...
Armin Stucki, L. Jiang, F. Acosta, P. Gerber, M. Cottagnoud, O Acosta, Wang, Guoqiang, Gerber, Peter, G. Wang, P. Cottagnoud, Nguyen, Phong, Cottagnoud, Marianne, Phan, Ly T, Ly T. Phan, Cottagnoud, Philippe, D. Wachtel, Peter Gerber, Stucki, Armin, Acosta, Fernando, P. Nguyen, Wachtel, Derek, Guoqiang Wang, A. Stucki, Lijiang Jiang, Marianne Cottagnoud, Phong Nguyen, Derek Wachtel, Jiang, Lijiang, L. T. Phan   +28 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A penicillin története

, 2010
A szakdolgozatom fő témája a penicillin és felfedezésének története a 20.századól napjainkig.Felfedezés előzményeinek története és a Magyarországi penicillin gyártás is része,továbbá betekintést kaphat az olvasó a penicillin természete és félszintetikus ...
Csordás, Norbert Zsolt
core  

Characteristics of coagulase positive staphylococci isolated from milk in cases of subclinical mastitis

Acta Veterinaria, 2014
Coagulase-positive staphylococci are the most common pathogen causing subclinical mastitis in cows. Their main characteristic is a high virulence which leads to chronic infection.
Rajić Savić Nataša, Katić Vera, Velebit Branko   +2 more
doaj   +1 more source