Results 91 to 100 of about 804,907 (316)

An internationally spread clone of Streptococcus pneumoniae evolves from low-level to higher-level penicillin resistance by uptake of penicillin-binding protein gene fragments from nonencapsulated pneumococci.

open access: yes, 2004
Low-level penicillin resistance in an international Streptococcus pneumoniae serotype 19F clone emerging in Switzerland was characterized by mutations in the penicillin-binding protein PBP2x.
Hauser, Christoph   +2 more
core   +1 more source

Antimicrobial Desensitization: A Review of Published Protocols

open access: yesPharmacy, 2019
Antimicrobial desensitization represents a last-line option for patients with no alternative therapies, where the benefits of this intensive process must outweigh the potential harm from drug exposure. The goal of antimicrobial desensitization procedures
Daniel B. Chastain   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

First report of Actinomyces europaeus bacteraemia result from a breast abscess in a 53-year-old man

open access: yesNew Microbes and New Infections, 2015
This is the first report of Actinomyces europaeus bacteraemia in a 53-year-old man. The bacteraemia was the result of a breast abscess. Identification was established by matrix-assisted desorption ionization–time of flight mass spectrometry and confirmed
H.L. Nielsen
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid

open access: yes, 2016
Penicillin G is a widely used antibiotic, but the traditional volatile organic solvent extraction causes serious environmental problems. In this work, a hydrophobic ionic liquid ([Bmim]PF6) was developed as a new extraction agent for recovery of ...
Li, Yingbo   +5 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Heteroresistance to penicillin in Streptococcus pneumoniae

open access: yes, 2007
Heteroresistance to beta-lactam antibiotics has been mainly described for staphylococci, for which it complicates diagnostic procedures and therapeutic success.
Morand, Brigitte, Mühlemann, Kathrin
core   +1 more source

Prophylaxis and Treatment for Leptospirosis: Where are the Evidences?

open access: yesNational Journal of Physiology, Pharmacy and Pharmacology, 2012
Leptospirosis is a zoonosis of worldwide distribution, caused by infection with pathogenic spirochetes of genus leptospira. The disease is maintained in nature by chronic renal infection of carrier mammals like rats, cattles, dogs etc, which excrete the ...
Jaykaran Charan   +2 more
doaj   +1 more source

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