Results 91 to 100 of about 49,568 (258)

Effects of EDP-420 on penicillin-resistant and quinolone- and penicillin-resistant pneumococci in the rabbit meningitis model [PDF]

, 2008
OBJECTIVES: To test the efficacy of EDP-420, a new ketolide, in experimental pneumococcal meningitis and to determine its penetration into the CSF. METHODS: The experimental rabbit model was used in this study and EDP-420 was tested against a penicillin ...
Armin Stucki, L. Jiang, F. Acosta, P. Gerber, M. Cottagnoud, O Acosta, Wang, Guoqiang, Gerber, Peter, G. Wang, P. Cottagnoud, Nguyen, Phong, Cottagnoud, Marianne, Phan, Ly T, Ly T. Phan, Cottagnoud, Philippe, D. Wachtel, Peter Gerber, Stucki, Armin, Acosta, Fernando, P. Nguyen, Wachtel, Derek, Guoqiang Wang, A. Stucki, Lijiang Jiang, Marianne Cottagnoud, Phong Nguyen, Derek Wachtel, Jiang, Lijiang, L. T. Phan   +28 more
core   +3 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Intrinsic Resistance: A Significant Characteristic in Evaluating Antibiotic Sensitivity Pattern [Response to Letter]

Infection and Drug Resistance, 2022
Asmamaw Nitsuh Woreta,1,2 Habtamu Biazin Kebede,1 Yonas Tilahun,3 Solomon Gebreselassie Teklegiorgis,1 Woldaregay Erku Abegaz1 1Department of Microbiology, Immunology and Parasitology, College of Health Sciences, Addis Ababa University, Addis Ababa ...
Woreta AN, Kebede HB, Tilahun Y, Teklegiorgis SG, Abegaz WE   +4 more
doaj  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Penicillin G plus an aminoglycoside in febrile neutropenia [PDF]

, 2013
Lege og forsker Dag Torfoss har i sin avhandling Penicillin G plus an aminoglycoside in febrile neutropenia oppsummert studier med penicillin og aminoglykosid ved feber etter cellegiftbehandling.
Torfoss, Dag
core   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Advertisment for Penicillin.

, 1940
Advertisment during World War II promoting the use of ...

core  

Penicillin Resistance Compromises Nod1-Dependent Proinflammatory Activity and Virulence Fitness of Neisseria meningitidis [PDF]

, 2013
SummaryNeisseria meningitidis is a life-threatening human bacterial pathogen responsible for pneumonia, sepsis, and meningitis. Meningococcal strains with reduced susceptibility to penicillin G (PenI) carry a mutated penicillin-binding protein (PBP2 ...
LeBourhis, Lionel, Thouron, Françoise, Werts, Catherine, Eberl, Gérard, Taha, Muhamed-Kheir, El Ghachi, Meriem, Zarantonelli, Maria Leticia, Sansonetti, Philippe, Vives, Francina Langa, Girardin, Stephen E., Pedron, Thierry, Mulet, Céline, Peduto, Lucie, Girardin, Stephen, E., Boneca, Ivo, Gomperts, d’Andon, Martine Fanton, Skoczynska, Anna, Szatanik, Marek, Deghmane, Ala-Eddine, Nato, Faridabano, Boneca, Ivo G., Philpott, Dana J., Antignac, Aude, d'Andon, Martine Fanton, Philpott, Dana   +24 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The Name “Penicillin” [PDF]

Nature, 1947
THE recent note “Aspergillin: a Name Misapplied to Several Different Antibiotics”, in which Tobie1 deprecates the practice of assigning names to antibiotics without due consultation of the literature, prompts me to point out, for its historical interest, that even penicillin has not escaped such a duplication in naming.
openaire   +2 more sources