Results 51 to 60 of about 1,094,475 (308)
Engineering the substrate specificity of a thermophilic penicillin acylase from thermus thermophilus [PDF]
, 2013 A homologue of the Escherichia coli penicillin acylase is encoded in the genomes of several thermophiles, including in different Thermus thermophilus strains.
Berenguer, José +7 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Congenital syphilis neonatal alterations in a university hospital in Niterói - RJ
DST, 2013 Introduction: Syphilis is a sexually transmitted disease caused due to bacterium Treponema pallidum. The prevalence of this infection decreased significantly by the use of penicillin, but it is observed that it reappears particularly in cases of ...
Philippe Godefroy C de Souza +5 more
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Novel β-lactamase inhibitors: a therapeutic hope against the scourge of multidrug resistance
Frontiers in Microbiology, 2013 The increasing incidence and prevalence of multidrug resistance (MDR) among contemporary Gram-negative bacteria represents a significant threat to human health.
Richard eWatkins +3 more
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
A Case Report of Pregnant Female with Cutaneous Anthrax
پزشکی بالینی ابن سینا, 2013 Introduction: Anthrax is an acute infection caused by the Bacillus anthracis, a gram-positive organism, aerobic, sporulating rod.. Basilus anthracis causes pulmonary, gastrointestinal and cutaneous disease.
Gholamreza Eshghi +3 more
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Aptamer-Based Biosensors for Antibiotic Detection: A Review
Biosensors, 2018 Antibiotic resistance and, accordingly, their pollution because of uncontrolled usage has emerged as a serious problem in recent years. Hence, there is an increased demand to develop robust, easy, and sensitive methods for rapid evaluation of antibiotics
Asol Mehlhorn +2 more
doaj +1 more source
Facilitation of penicillin haptenation to serum proteins. [PDF]
, 1993 Traditionally, penicillin binding to serum proteins was believed to be a passive chemical process; however, it appears to be facilitated by serum factors.
Adkinson, N. Franklin, Jr. +2 more
core +3 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Post Penicillin Antibiotics: From acceptance to resistance? [PDF]
, 2000 Edited transcript of a Witness Seminar held at the Wellcome Institute for the History of Medicine, in London, on 12 May 1998. First published by the Wellcome Trust, 2000. ©The Trustee of the Wellcome Trust, London, 2000.
Reynolds, LA, Tansey, EM
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